DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rrp1 and Nolc1

DIOPT Version :9

Sequence 1:	NP_001137776.1	Gene:	Rrp1 / 33500	FlyBaseID:	FBgn0004584	Length:	706	Species:	Drosophila melanogaster
Sequence 2:	NP_074060.2	Gene:	Nolc1 / 64896	RGDID:	621578	Length:	704	Species:	Rattus norvegicus

Alignment Length:	426	Identity:	109/426 - (25%)
Similarity:	177/426 - (41%)	Gaps:	71/426 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 AVKKQAEALASEPTDPTPNANGNGVDENADSAAEELKVPAKGK--------PRARKATKTAVSAE 62
            |.|||..|.|.......|....:..::::....||.|.|.|.|        |.:...:|.:|.|:
  Rat   253 APKKQVVAKAPVKVTAAPTQKSSSSEDSSSEEEEEQKKPMKKKAGPYSSVPPPSVSLSKKSVGAQ 317

  Fly    63 NSEEVEPQKAPT-----------AAARGKKKQPKDTDENGQMEVVAKPKGRAKKATAEAEPEPKV 116
            :.::...|..|.           :::..:||.|..|..:   :..|||....|||.:.::.....
  Rat   318 SPKKAAAQTQPADSSADSSEESDSSSEEEKKTPAKTVVS---KTPAKPAPVKKKAESSSDSSDSD 379

  Fly   117 DLPAGKATKP-RAKKEPTPAPDEVTSSPPKGRAKAEKPTNAQAKGRKRKELPAEANGGAEEAAEP 180
            ........|| .|.|.|...| .||..||..:|.| .|......|:|.:...|:::...||::.
  Rat   380 SSEDEAPAKPVSATKSPLSKP-AVTPKPPAAKAVA-TPKQPAGSGQKPQSRKADSSSSEEESSS- 441

  Fly   181 PKQRARKEAVPTLK----EQAEPGTISKEKVQKAETAAKRARGTKRLADSEIAAALDEPEVDEVP 241
            .::.|.|::|.|.|    .:|.|...:|:        |.||.|... :|||.:::.:|.:....|
  Rat   442 SEEEATKKSVTTPKARVTAKAAPSLPAKQ--------APRAGGDSS-SDSESSSSEEEKKTPPKP 497

  Fly   242 PKAASKRAKKGKMVEPSP---------ETVGDFQSVQEEVESPPKTAAAPKKRAKK------TTN 291
            |  |.|:|....:.:|:|         .:....:...||.:..||:.|.||.:|.|      :.|
  Rat   498 P--AKKKAAGAAVPKPTPVKKAAAESSSSSSSSEDSSEEEKKKPKSKATPKPQAGKANGVPASQN 560

  Fly   292 GETAVELEPKTKAKPTKQRAKKEGKEPAPGKKQKKSADKENGVVEEEAK-----PSTETKPAKGR 351
            |:...|.|  .:.:.|:|..|..|.:|..|||:|.:...:.....:..|     |:|..|..||.
  Rat   561 GKAGKESE--EEEEDTEQNKKAAGTKPGSGKKRKHNETADEAATPQSKKVKLQTPNTFPKRKKGE 623

  Fly   352 KKAP-----VKAEDVEDIEEAAEESKPARGRKKAAA 382
            |:|.     |:.|::|.....|:.|..|   |:.||
  Rat   624 KRASSPFRRVREEEIEVDSRVADNSFDA---KRGAA 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rrp1	NP_001137776.1	RecX	15..>217	CDD:294607	51/225 (23%)
		RR_TM4-6	<314..>388	CDD:283990	23/79 (29%)
		Ape1-like_AP-endo	454..704	CDD:197321
Nolc1	NP_074060.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	65..638		102/403 (25%)
		11 X 12 AA approximate repeats of an acidic serine cluster	84..570		83/335 (25%)
		PHA03247	<147..561	CDD:223021	79/324 (24%)
		SRP40_C	629..701	CDD:398615	9/31 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2992
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900