DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rrp1 and apex1

DIOPT Version :9

Sequence 1:	NP_001137776.1	Gene:	Rrp1 / 33500	FlyBaseID:	FBgn0004584	Length:	706	Species:	Drosophila melanogaster
Sequence 2:	XP_012813846.2	Gene:	apex1 / 394929	XenbaseID:	XB-GENE-977072	Length:	363	Species:	Xenopus tropicalis

Alignment Length:	346	Identity:	163/346 - (47%)
Similarity:	214/346 - (61%)	Gaps:	43/346 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   373 PARGRKKAAAKAEEPDVDEESGSKSMLAEQSGCGGAAVLKSLQTMLNFCFPATKKAKKAETKTT- 436
            |.||:|:..:.||    .:|.|::                          |..||.||...|..
Frog    49 PKRGKKEEVSGAE----PQEDGNE--------------------------PEVKKGKKGAGKAAK 83

  Fly   437 ----VTLDKDA-FALPAD--KEFNLKICSWNVAGLRAWLKKDGLQLIDLEEPDIFCLQETKCAND 494
                |.|.:|| ..|.:|  |::.|||.||||.|:|||:||.||..:..|:|.|.||||.|||..
Frog    84 EPEPVVLYEDAPDNLTSDDGKKYTLKISSWNVDGIRAWIKKQGLNWVREEDPHIMCLQEIKCAEK 148

  Fly   495 QLPEEVTRLPGY-HPYWLCMPG---GYAGVAIYSKIMPIHVEYGIGNEEFDDVGRMITAEYEKFY 555
            .||.|:..:|.| |.||.| |.   ||:|||:..|..|::|.||||.||.|..||:||||::.|:
Frog   149 LLPPEIKDMPEYPHKYWAC-PDEKEGYSGVAMLCKDKPLNVTYGIGIEEHDKEGRVITAEFDSFF 212

  Fly   556 LINVYVPNSGRKLVNLEPRMRWEKLFQAYVKKLDALKPVVICGDMNVSHMPIDLENPKNNTKNAG 620
            ||..|||||.|.||.|:.|.||:..|:||:|.||:.||:::|||:||:|..|||:|||.|.|..|
Frog   213 LIAAYVPNSSRGLVRLDYRQRWDVDFRAYLKGLDSKKPLILCGDLNVAHQEIDLKNPKTNKKTPG 277

  Fly   621 FTQEERDKMTELLGLGFVDTFRHLYPDRKGAYTFWTYMANARARNVGWRLDYCLVSERFVPKVVE 685
            ||.:||....|||..|::|:||.||||:..||||||||.||||:||||||||.::|:...|.:.:
Frog   278 FTPQERQGFGELLAEGYLDSFRELYPDKPSAYTFWTYMMNARAKNVGWRLDYFVLSKALRPALCD 342

  Fly   686 HEIRSQCLGSDHCPITIFFNI 706
            .::||:.:||||||||:...|
Frog   343 SKVRSKIMGSDHCPITLLMAI 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rrp1	NP_001137776.1	RecX	15..>217	CDD:294607
		RR_TM4-6	<314..>388	CDD:283990	6/14 (43%)
		Ape1-like_AP-endo	454..704	CDD:197321	141/253 (56%)
apex1	XP_012813846.2	Ape1-like_AP-endo	108..361	CDD:197321	141/253 (56%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	283	1.000	Domainoid score	I1624
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005771
OrthoInspector	1	1.000	-	-		oto104181
Panther	1	1.100	-	-	LDO	PTHR22748
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R72
SonicParanoid	1	1.000	-	-		X5491
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.040