DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rrp1 and Apex2

DIOPT Version :9

Sequence 1:	NP_001137776.1	Gene:	Rrp1 / 33500	FlyBaseID:	FBgn0004584	Length:	706	Species:	Drosophila melanogaster
Sequence 2:	NP_001073361.1	Gene:	Apex2 / 317628	RGDID:	1565983	Length:	516	Species:	Rattus norvegicus

Alignment Length:	332	Identity:	97/332 - (29%)
Similarity:	144/332 - (43%)	Gaps:	100/332 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   454 LKICSWNVAGLRAWLKKDGL-------------QLIDLEEPDIFCLQETKCANDQLPEEVTRLPG 505
            |::.|||:.|:|:.|:  ||             :::|..:.||.||||||...|.|.|.:..:.|
  Rat     2 LRVVSWNINGIRSPLQ--GLAGQEPSNSPTALRRVLDELDADIVCLQETKVTRDVLTEPLAIVEG 64

  Fly   506 YHPYWLC--MPGGYAGVAIYSK--IMPIHVEYGI--------------GN-EEF--------DDV 543
            |:.|:..  ...||:|||.:.|  ..|:..|.|:              || :||        |..
  Rat    65 YNSYFSFSRSRSGYSGVATFCKDSATPVAAEEGLSGVFATLNGDIGCYGNTDEFTQEELRVLDSE 129

  Fly   544 GRMITAEY--------EK-FYLINVYVPNSG-RKLVNLEPRMRWEKLFQAYVKKLDAL-KPVVIC 597
            ||....::        || ..|||||.|::. .|...|..:||:.:|.|...:.|.|. ..|:|.
  Rat   130 GRAFLTQHKIRTLEGKEKTLTLINVYCPHADPGKPERLTFKMRFYRLLQIRAEALLAAGSHVIIL 194

  Fly   598 GDMNVSHMPID----------------------LENPKNNT-KNAGFTQEERDKMTELLGLGFVD 639
            ||:|.:|.|||                      |.||.|.. .:.|.               |:|
  Rat   195 GDLNTAHRPIDHCDASSLECFEEDPGRKWMDGLLSNPGNEAGPHIGH---------------FMD 244

  Fly   640 TFRHLYPDRKGAYTFWTYMANARARNVGWRLDY-----CLVSERFVPKVVEHEIRSQCLGSDHCP 699
            :||:.:|.::.|:|.|:.::.||..|.|.||||     .||.:.|....:..|:    :||||||
  Rat   245 SFRYFHPKQQRAFTCWSVVSGARHLNYGSRLDYVLGDRSLVIDTFQASFLLPEV----MGSDHCP 305

  Fly   700 ITIFFNI 706
            :....|:
  Rat   306 VGAVLNV 312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rrp1	NP_001137776.1	RecX	15..>217	CDD:294607
		RR_TM4-6	<314..>388	CDD:283990
		Ape1-like_AP-endo	454..704	CDD:197321	96/328 (29%)
Apex2	NP_001073361.1	Ape2-like_AP-endo	3..310	CDD:197322	95/327 (29%)
Apex2	NP_001073361.1	zf-GRF	463..512	CDD:284302
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0708
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810