DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rbp9 and Sxl

DIOPT Version :9

Sequence 1:	NP_001259974.1	Gene:	Rbp9 / 33498	FlyBaseID:	FBgn0010263	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_001259303.1	Gene:	Sxl / 3772180	FlyBaseID:	FBgn0264270	Length:	722	Species:	Drosophila melanogaster

Alignment Length:	761	Identity:	191/761 - (25%)
Similarity:	312/761 - (40%)	Gaps:	180/761 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 GASGVGSTTGSAGGPATA-NNVTN-------SQAQTNGGTT--ATTTAAAGAGSTTNAAVGQATA 74
            |.:..||...:.|.|... ||.::       |.:..:|..|  :..::::..|.......|.:..
  Fly     3 GNNNPGSNNNNGGYPPYGYNNKSSGGRGFGMSHSLPSGMDTEFSFPSSSSRRGYNDFPGCGGSGG 67

  Fly    75 NNAASNNNNNNN-------NTNNNNNN----NATANNNNNNEPDPK---TNLIVNYLPQTMSQDE 125
            |..::||....|       .:||:.||    :..:..:::...||:   ||||||||||.|:..|
  Fly    68 NGGSANNLGGGNMCHLPPMASNNSLNNLCGLSLGSGGSDDLMNDPRASNTNLIVNYLPQDMTDRE 132

  Fly   126 IRSLFVSFGEVESCKLIRDKVTGQSLGYGFVNYVKQEDAEKAINALNGLRLQNKTIKVSIARPSS 190
            :.:||.:.|.:.:|:::||..||.|.||.||::..:.|:::||..|||:.::||.:|||.|||..
  Fly   133 LYALFRAIGPINTCRIMRDYKTGYSFGYAFVDFTSEMDSQRAIKVLNGITVRNKRLKVSYARPGG 197

  Fly   191 ESIKGANLYVSGLPKNMTQSDLESLFSPYGKIITSRILCDNITGLSKGVGFIRFDQRFEADRAIK 255
            ||||..||||:.||:.:|...|:::|..||.|:...||.|.:||..:||.|:|:::|.||..||.
  Fly   198 ESIKDTNLYVTNLPRTITDDQLDTIFGKYGSIVQKNILRDKLTGRPRGVAFVRYNKREEAQEAIS 262

  Fly   256 ELNGTTPKNSTEPITVKFANNPSSNKNSMQPLAAYIAPQNTRGGRAFPANAAAGAAAAAAAAAIH 320
            .||...|:..::|::|:.|......|.:.......:.|.|..     |......|..|||...:|
  Fly   263 ALNNVIPEGGSQPLSVRLAEEHGKAKAAHFMSQMGVVPANVP-----PPPPQPPAHMAAAFNMMH 322

  Fly   321 PNAGRYSSVISRYSPLTSDLITNGMIQGNTIASSGWCIFVYNLAPDTEENVLWQLFG-----PFG 380
            .: |....:.|.:..:                    |..::.|..:...::|..|:.     |:.
  Fly   323 RD-GAMEKLRSLFDAI--------------------CDAIFGLDSENFADLLDGLYRRKYHYPYL 366

  Fly   381 AVQSVKVIRDLQSNKCKGFGFVTMTNYEEAVLAIQSLNGYTLGNRVLQVSFKTNKNKQTXLLTKL 445
             :...:..:.||..: :..||.:.:|.     :|.:.||......:....:...:.:|..|
  Fly   367 XLTPQQQQQLLQHQQ-QALGFTSSSNN-----SIGNGNGNDNNMLLYHQQYHQQQTQQQRL---- 421

  Fly   446 AAVVNANAAAAALAANG-----------------------LVLH--------------------- 466
                 .|.||..::.||                       ..||
  Fly   422 -----GNVAAHNISPNGSNNNINTSNTNNINFNTIRQNGVAALHYLQEQLQLQQPQDQQSQQQQP 481

  Fly   467 ---------------NHHHH------------SNIGSINNNSNNSN----------------GCS 488
                           :||:.            ||..|.|||||.||                ..|
  Fly   482 LTMPSSPPFQQQSRQSHHNGSSSTLGNQLLAISNNNSFNNNSNQSNSFTGNYSNGSAFTSNGAIS 546

  Fly   489 AAAFP-----LGKYVNHSSNNRQHNINNSTSNTSKQKPASTSNKQQSMAPPKRLASSTAATTGDL 548
            .:.||     .|.:.|:|:|:...|..:..||.     |.:||....::......:|....|.:.
  Fly   547 GSNFPNNPTSSGNFTNNSTNSNPTNSGHFASNL-----AGSSNFTNHLSGSNNYTNSNGNFTSNA 606

  Fly   549 AATA-----ATNSSSSSHSASSGDAGATGTAASSSSSSSSTNNNILKTSTKFIYNKPQNQYELLQ 608
            |:::     |.:|::.|.:.|||..|.:...:.|...:::|||:.......|.:|....:.||.|
  Fly   607 ASSSNFSNNAASSTNYSKNCSSGVVGNSDPDSCSRKHTTNTNNHHTSPQHDFSFNMSTTEQELHQ 671

  Fly   609 QQLQLQQEFAQFLTNVANSAATPSSNGS--------ANSTNQRNGG 646
            |.|:|||.......|...:|||.|:..|        |:|||..|.|
  Fly   672 QTLKLQQLHLNNSFNNTTAAATTSAAASTSTSTTATASSTNSANVG 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rbp9	NP_001259974.1	ELAV_HUD_SF	107..438	CDD:273741	101/338 (30%)
		RRM1_Hu	109..186	CDD:241094	36/79 (46%)
		RRM2_Hu	196..274	CDD:241096	31/77 (40%)
		RRM3_Hu	355..432	CDD:240823	13/81 (16%)
Sxl	NP_001259303.1	RRM1_SXL	117..197	CDD:241093	39/79 (49%)
Sxl	NP_001259303.1	RRM2_Hu_like	203..281	CDD:240822	31/77 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I3499
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000313
OrthoInspector	1	1.000	-	-		mtm1072
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.910