DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rbp9 and crp79

DIOPT Version :9

Sequence 1:	NP_001259974.1	Gene:	Rbp9 / 33498	FlyBaseID:	FBgn0010263	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_001018242.1	Gene:	crp79 / 3361521	PomBaseID:	SPAC1610.03c	Length:	710	Species:	Schizosaccharomyces pombe

Alignment Length:	741	Identity:	145/741 - (19%)
Similarity:	224/741 - (30%)	Gaps:	257/741 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 NNNNNNEP----DPKTNLIVNYLPQTMSQDEIRSLFVSFGEVESC--KLIRD----------KVT 147
            ||:..:.|    |..:.:.|..:...:|.:||...|..:|:|||.  :|:..          |..
pombe     2 NNSKLSVPGQYEDESSTIYVGNIDSRLSDEEIIKHFSKYGQVESIFRRLLDSFYPKEKAKPFKPP 66

  Fly   148 GQSLGYGFVNYVKQEDAEKAINALNGLRL-QNK-TIKVSIARPSS-------------------- 190
            ...:.||||.:|..|..|:.:....|:.| |.| |||..:..|:.
pombe    67 KNGVQYGFVKFVNAESIEEVLKDAKGMTLGQRKLTIKARVVNPAKLTDKKFKPNDTSITANVFNP 131

  Fly   191 --------------------------------ESIKGAN-------------------------- 197
                                            |:::|.|
pombe   132 SIQNNTDEENVKPGLKQSQIKEFIPNVEERNWETVRGINSRNPKPETTLTIPSLGLEDISMQVVP 196

  Fly   198 --------LYVSGLPKNMTQSDLESLFSPYGKIITSRILCDNITGLSKGVGFIRF-DQR------ 247
                    |.:..||..:|..||.:.|..              .|:.||....:| |||
pombe   197 NAFASTLPLSILNLPAEVTPIDLYNHFKQ--------------AGVVKGTAVSQFLDQRGFRYGE 247

  Fly   248 ------FEADRAIKELNGTTPKNSTEPITVKFANNPSSNKNSM--QPLAAYIAP---QNTRGGRA 301
                  .....||::||....|.|...:::|  |..||:..|:  .|....:.|   :|....:.
pombe   248 VIMDSVESCQNAIEKLNNVPYKGSILEVSIK--NKASSSVKSIPTTPTGESLWPFPSENANKTQI 310

  Fly   302 FPANAAA-----------------GAAAAAAAA--AIHP---NAGRYSSVISRYSPL--TSDLIT 342
            ...||..                 |:.:....:  ..||   |.......|..:..|  :|..|.
pombe   311 NIENATCSKMTWIMGSPTKEKSQWGSVSTTGVSNQQNHPAAWNPDNKPQSIVHWDSLRESSPSIP 375

  Fly   343 NGMIQGNTIASSGWCIFVYNLAPDTE---ENVLWQLFGPFGAVQSVKVIRDLQSNKCKGFGFVTM 404
            |..|..:.       ::|.|| .||.   ::.|..||.|||::.|..:.....|...||:|||..
pombe   376 NSPIDPSN-------LYVKNL-DDTVITCKSQLEDLFSPFGSILSSMLACYPNSGISKGYGFVAF 432

  Fly   405 TNYEEAVLAIQSLNGYTLGNRVLQVSFKTNK----------------NKQTXLLTKLAAVVNANA 453
            ...|.||.|..:|||..:|.:.:.|.|...|                ::||......|..|....
pombe   433 RQIEAAVRAKDTLNGMMVGKKRIFVCFAERKSDRIRRLQAFFANKPTSEQTAQQDNKALFVKPER 497

  Fly   454 AAAALAANGLVLHNHHHHSNIGSINNNSNNSN----GCSAAAFPLGKYVNHSSNNR--------- 505
            ::.......:....:....|..::::...|.|    |.:.......:|||....|:
pombe   498 SSTVTIRKPIESSTNKISENPTTLSSKVENKNEPKTGENKEPSQTNEYVNCKQENKELSGQLSGN 562

  Fly   506 ---------------QHNI--------NNSTSNTSKQKPASTS---NKQQSMAPPKRL------- 537
                           |.|:        |...:|....|..||:   .|.|.|...|:|
pombe   563 LDIKKEAGKLSHDGEQGNLLKPLVFHANTKLNNRGSAKMGSTATNLKKIQDMLHNKKLSNAYFVP 627

  Fly   538 -ASSTAATTGDLAATAATNSSSSSHSASSGDAGATGTAASSSSSSS------------STNNNIL 589
             |.:|..||........::......:.|:......|...|...::|            |...|.|
pombe   628 RARATTCTTLTYVTVEPSHFQDEDCNESTNMLSLVGYMDSYPEATSNIQKMNSYHIKDSNKENFL 692

  Fly   590 KTSTKFIYNKPQNQYELLQQQLQLQQ 615
            .| ||...|.|..        :||.|
pombe   693 ST-TKVNNNSPTT--------IQLTQ 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rbp9	NP_001259974.1	ELAV_HUD_SF	107..438	CDD:273741	99/491 (20%)
		RRM1_Hu	109..186	CDD:241094	25/90 (28%)
		RRM2_Hu	196..274	CDD:241096	22/124 (18%)
		RRM3_Hu	355..432	CDD:240823	27/79 (34%)
crp79	NP_001018242.1	RRM_RBM18	18..106	CDD:240801	25/87 (29%)
		RRM	109..>289	CDD:223796	29/195 (15%)
		RRM_SF	205..276	CDD:240668	20/84 (24%)
		RRM2_I_PABPs	380..459	CDD:240825	27/86 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	58	1.000	Domainoid score	I3078
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.960