DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rbp9 and Raver2

DIOPT Version :9

Sequence 1:	NP_001259974.1	Gene:	Rbp9 / 33498	FlyBaseID:	FBgn0010263	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_898845.1	Gene:	Raver2 / 242570	MGIID:	2443623	Length:	673	Species:	Mus musculus

Alignment Length:	701	Identity:	138/701 - (19%)
Similarity:	222/701 - (31%)	Gaps:	213/701 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 AQTNGGTTATTTAAAGAGSTTNAAVGQATANNAASNNNNNNNNTNNNNNNNATANNNNNNEPDPK 109
            |...||       |.||||.:..:.|  ||..||............:....|........|...:
Mouse     2 AARGGG-------AGGAGSGSGPSAG--TAGEAAEPALRPGEVAALHPQEVAARLQRMRRELSNR 57

  Fly   110 TNLIVNYLPQTMSQDEIRSLFVSFGEVESCKLIRDKVTGQSLGYGFVNYVKQEDAEKAINALNGL 174
            ..::|..|||..|..|:..|...: |::.|.:.|:|.|      .||..:..|.|:.||...:..
Mouse    58 RKILVKNLPQDSSSQEVHELLQDY-ELKYCYVDRNKRT------AFVTLLNGEQAQSAIQRFHQF 115

  Fly   175 RLQNKTIKVSIARPSSESIKGANLYVSGLPKNMTQSDLESLFSPYGKIITSRILCDNITGLSKGV 239
            ..:.:.:.|.: :|:.     |.|.::.||.:.|..:.|.|...||.|....::...:||.|||.
Mouse   116 SFRGRELTVQL-QPTD-----ALLCITNLPISFTLEEFEELVRAYGNIERCFLVYSEVTGHSKGY 174

  Fly   240 GFIRFDQRFEADRAIKELNGTTPKNSTEPITVKFANNPSSNKNSMQPLAAYIAPQNTRGGRAFPA 304
            ||:.:.::..|.:|..||.|
Mouse   175 GFVEYMKKDFAAKARLELLG--------------------------------------------- 194

  Fly   305 NAAAGAAAAAAAAAIHPNAGRYSSVISRYSPLTSDLITNGMIQGNTIASSGWCIFVYNLAPD-TE 368
             ...||:|..|         ::..|    :.|.|:||.:.            |:.:..|..| ::
Mouse   195 -RQMGASALFA---------QWMDV----NLLASELIHSK------------CLCIDKLPSDYSD 233

  Fly   369 ENVLWQLFGPFGAVQSVKVIRDLQSNKCKGFGFVTMTNYEEAVLAIQSLNGYTLGNRVLQVSFKT 433
            ...|.|||.........::.:| :.:...||..|..:..|.|....|..:|.|:....:|:||
Mouse   234 SEELLQLFSGIHKPVFCQLAQD-EGSHGGGFAVVEYSTAEHAEEVQQVADGITIKGSQVQLSF-- 295

  Fly   434 NKNKQTXLLTKLAAVVNANAAAAALAANGLVLHNHHH----HSNIGSINNNSNN---------SN 485
                       .|......:..|.|.|....:|::..    ..|...|..:.||         ..
Mouse   296 -----------CAPGAPGRSTLAVLIAAQRAMHSNQKGLLPEPNPVQIMKSLNNPAMLQVLLQPQ 349

  Fly   486 GCSAAAFP---------------LGKYVNHSSNNRQHNINNSTSNTSKQK--------------- 520
            .|..|..|               |...:.|.|..:|.:...:||:...|.
Mouse   350 LCGRAMKPVLGVAPSLSHLLSPSLPSAILHFSKAQQSSAVGNTSSLILQNLSPLPLIQQQLMKFD 414

  Fly   521 PASTSNKQQSMAPPKRLASSTAATTG-------DLAATAATNSSSS------------------S 560
            .|.|:||...:..|..:....|...|       ||......:.:|:                  |
Mouse   415 NAHTNNKPGLLGEPPAMVLQPALAIGPPLPLKTDLGHHGEAHKTSNLIPPQTTLAAGLGMLPFFS 479

  Fly   561 HSASSGDAG-ATGTAASSSSSSSSTNNNILKTSTKFIYNKP------------------------ 600
            :...:|.|| ..||.....|:|.|.:......|..::...|
Mouse   480 NQLPAGQAGPGRGTTQEKQSASVSISEASFSGSQHYLQTFPGLPAGGPLTGNQKTPQSQPKGTEV 544

  Fly   601 --QNQYELL---QQQLQLQQ----EFAQFLTNVANSAA---TPSSNGSANS 639
              :||..||   .::::|.:    ..|..|.:|..|.|   .|...|.|::
Mouse   545 ASKNQTSLLGEPPKEIRLSKNPYLNLASVLPSVCLSTAGKGMPPKTGIASN 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rbp9	NP_001259974.1	ELAV_HUD_SF	107..438	CDD:273741	70/331 (21%)
		RRM1_Hu	109..186	CDD:241094	19/76 (25%)
		RRM2_Hu	196..274	CDD:241096	22/77 (29%)
		RRM3_Hu	355..432	CDD:240823	18/77 (23%)
Raver2	NP_898845.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34		13/40 (33%)
		RRM_SF	59..128	CDD:302621	19/76 (25%)
		RRM2_RAVER2	132..208	CDD:241110	25/130 (19%)
		RRM_SF	218..314	CDD:302621	23/121 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	481..549		10/67 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0145
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900