Protein Alignment lilli and Aff4

DIOPT Version :10

• Sequence 1: NP_523464.1
• Gene: lilli / 33496
• FlyBaseID: FBgn0041111
• Length: 1673
• Species: Drosophila melanogaster
• Sequence 2: NP_291043.1
• Gene: Aff4 / 93736
• MGIID: 2136171
• Length: 1160
• Species: Mus musculus
• Alignment Length: 1681
• Identity: 361/1681 - (21%)
• Similarity: 541/1681 - (32%)
• Gaps: 620/1681 - (36%)

  Fly    65 RRKRREREKIERQQGIQIDDRETSLFGEPRRLTEGD----AEITAALGEFFEAREYINNQT---- 121
            |.|.|||...|.|||.......:.||.||.::|..:    :.|.:.||.:.|.::||.:::
Mouse    10 RMKERERRNQEIQQGEDAFPPSSPLFAEPYKVTSKEDKLSSRIQSMLGNYDEMKDYIGDRSIPKL 74

  Fly   122 VGISRSA-PGAGNPRLQPNLAPQAKSLGHSPSSASSAAGPTAASATTSLPGQQQHYQQQQRPPTY 185
            |.|.:.| |...:.:..||...|.    |..|..||...|...:.:||        |.|:|  :.
Mouse    75 VAIPKPAVPTTTDEKANPNFFEQR----HGGSHQSSKWTPVGPAPSTS--------QSQKR--SS 125

  Fly   186 VKQADNKPPYNGRGG----YPGQPMKNDIPSSS------------GMAPPRGPPRTSSSNSNSSS 234
            ..|:.:....:|.||    ..||....|..|||            ..:...|.|:..||.|:|.|
Mouse   126 ALQSGHSSQRSGAGGSGASSSGQRHDRDSYSSSRKKGQHGSEHSKSRSSSPGKPQAVSSLSSSHS 190

  Fly   235 VT---NNASSGGVPASTPLGPPLSTQMP------NGREKSFLGPPAPALHNGTGGRFVPPAASKR 290
            .:   ::.|.....:.:|..|..:...|      :|:..|...|  |:|.:.:......|.|..|
Mouse   191 RSHGNDHHSKEHQRSKSPRDPDANWDSPSRGPFSSGQHSSQSFP--PSLMSKSSSMLQKPTAYVR 253

  Fly   291 PGVGQQPPPPEKDVNKIISDIANIFTVQPLTLIAATPHAPTRENYNL---LAPNRQKY--AMDIP 350
            |..||:...|     |:.|:                 |..::.:.|.   |.|:.:.:  .:.||
Mouse   254 PMDGQESVEP-----KLSSE-----------------HYSSQSHGNSMTELKPSSKAHLTKLKIP 296

  Fly   351 SSPPSAEPS---SLMTPLFAPITSPIAPLVT---TP--PQASQMPLGGATSGTILAGEALAPLHQ 407
            |.|..|..|   |.:..:...:|....|.:|   ||  .:.|:.|.
Mouse   297 SRPLDASVSGDVSCVDEILKEMTHSWPPPLTAIHTPCKTEPSKFPF------------------- 342

  Fly   408 LPPTMPKAASGVTSPGPVKPLKTEKNHSLEKQDSCLENDLELSESEDEQRKKEGRSGGNSSNSSE 472
              ||.....|.. .||..|...|.|..:..:..|.|::||:||.|||            |....:
Mouse   343 --PTKESQQSNF-GPGEQKRYSTAKTSNGHQSKSMLKDDLKLSSSED------------SDGEQD 392

  Fly   473 SDSSESGSESSSKNDLQHHPNHQQHHHQLQQQQQQQQATMQQQQVLQQQHRSQPLTSNGAQNKKF 537
            .|.:...|...|.::..||                                    .|.||.|.:
Mouse   393 CDKTMPRSTPGSNSEPSHH------------------------------------NSEGADNSR- 420

  Fly   538 RHEIIARGSNTITGLLSSSGFGSGGNVGPAGVNSNAVVGTGSGSGGTLSSGGSSSNKTPSPTESN 602
                  ..|::.:|..||||..|...              .|.|....:....|::..|.|..:|
Mouse   421 ------DDSSSHSGSESSSGSDSESE--------------SSSSDSEANEPSQSASPEPEPPPTN 465

  Fly   603 KWNLSRFFHKPANQTNSESVSPGNVSMKVPGILPGGAQIIPESIDVTTAIVKNEKNDMAMEEGEE 667
            ||.|..:.    |:.|...|||.:                  |:|
Mouse   466 KWQLDNWL----NKVNPHKVSPAS------------------SVD-------------------- 488

  Fly   668 EDDDEEQQLRYGGGLSVTPVAVKKEAIDAVSEMALGAIPKTQ-IKRESAETLLSARLSD-SGTSA 730
                                               ..||.:| .|:|..|...::..:| .||..
Mouse   489 -----------------------------------SNIPSSQAYKKEGREQGTASNYTDPGGTKE 518

  Fly   731 SGSSSSSSSSSDSAMGGEVVPMPGPGETLQLPGVPAAITTVMRVQPTQSQKAP-PSNSVTLTPIL 794
            :.|::....|.....|.|    .|.|.                      ||:| .|:|.|
Mouse   519 TSSATPGRDSKTIQKGSE----SGRGR----------------------QKSPAQSDSTT----- 552

  Fly   795 PLPTSPKQRQKKPRKKKAITSAPILDSSDDDEPPPKHPGLDHTAVSVQTQPATDTVKKGRGRPRK 859
            ...|..|::.|||.|..|            :||                          ||
Mouse   553 QRRTVGKKQPKKPEKSAA------------EEP--------------------------RG---- 575

  Fly   860 QQQSGGSGNLSSASAGSSSQTKGPTLTAAKKPLAKTPLAMSRARKREHSSQSSSNGNTPTKKVAT 924
                           |...:::.|...||..|.::...|...:||.....:|.|:.
Mouse   576 ---------------GLKIESETPVDMAASMPSSRHKAATKGSRKPNIKKESKSSP--------- 616

  Fly   925 PQLVAAPLKPTSNTAGSSSSDEDSSSSAESSSKSSSSSSSSDDTETQNTNCRIVKLNKTGAVQKK 989
                    :||:           .....:|:||.|..|....:|:|
Mouse   617 --------RPTA-----------EKKKYKSASKPSQKSREIIETDT------------------- 643

  Fly   990 ALLGSGSSSPSSSGSEAEDQTTRSQVGSGQALAQQLPPYKQLPISQHSQHLSSSDCSSSSGGCTA 1054
                   ||..|.|||:                  |||..|.|....|..             |.
Mouse   644 -------SSSDSDGSES------------------LPPSSQTPKYPESNR-------------TP 670

  Fly  1055 VCSSSSGEEDEGRREKERERKPKSDKNKINTLTRIFNPKEGGAKKQGQVVIVDLQEEQQQGKLDA 1119
            |..||..|||...|:                  |:|:|.|
Mouse   671 VKPSSVEEEDSFFRQ------------------RMFSPME------------------------- 692

  Fly  1120 AAQPSAPQAPPAAPAAIMAKPRMTPTQQQQLGAGLASPARTTTPHLTSLICKIDLSKLSRERIMR 1184
                                       :::|.:.|:.|     .....||.||||:.|:|.....
Mouse   693 ---------------------------EKELLSPLSEP-----DDRYPLIVKIDLNLLTRIPGKP 725

  Fly  1185 LKKLTPAQQNGHLTPKDQATNAVHVPNGYAGDTNPAAKVKHEHPVKPEPELDAGYEAKFKPGNVK 1249
            .|:..|        ||.:..|   ||.            ||...|:.:....|..:.|.|..|
Mouse   726 YKETEP--------PKGEKKN---VPE------------KHSREVQKQASEKASNKGKRKHKN-- 765

  Fly  1250 QEFQLKQERDRDRERERERERERERDREREQPPGRRRKRSSSSSSSPYKEKKRKKEKADQLQMGK 1314
                    .|..|..|.::.:..:::....:|...|    .||..|..||              |
Mouse   766 --------DDDTRASESKKPKTEDKNSSGHKPSSSR----ESSKQSSTKE--------------K 804

  Fly  1315 ELLPVPV--LLPSNNHERMPNHDRLSYDKLQLLHEDAAAVIGDVSAPNGSPTKKLLAMSPLPPPP 1377
            :|||.|.  :|..::.....:..|.......|...      |..|..|...:.|..:.|......
Mouse   805 DLLPSPAGPILSKDSKTEHGSRKRTVSQSSSLKSS------GTSSKENSGSSSKSSSSSTAKQKK 863

  Fly  1378 TVTVAPATCNEAVQTTP------PSATATSAIAPPVPATRLIY--RSYFDRDVEHPSDDPRKNNQ 1434
            |....|::..||.:..|      |.:|.||..:.| ..|:|.:  |:|   ..:|
Mouse   864 TEGKGPSSSKEAKEKAPNSSSNCPPSTPTSESSKP-RRTKLAFDDRNY---SADH---------- 914

  Fly  1435 FLQEAINRKHAADLERDSFNQVTLYLEAVVYFLLTADAMERCSSE-QATNTMYKDTLSLIKFIST 1498
            :||||...||.||...|.|.:...||:|||.|:...:|:|:.:.| ::...||.||:.|||: :.
Mouse   915 YLQEAKKLKHNADALSDRFEKAVYYLDAVVSFIECGNALEKNAQESKSPFPMYSDTVELIKY-TM 978

  Fly  1499 KFRPYQQQSTTNIQHETHNKVAILSLRCQSLISLKLYKLRRKDCRAIINSLTDFFR--------- 1554
            |.:.|.....|    ....::.:|.||||||:.|:|:||::::......:||:..:
Mouse   979 KLKNYLAPDAT----AADKRLTVLCLRCQSLLYLRLFKLKKENALKYSKTLTEHLKNSYSNSQAP 1039

  Fly  1555 -VGRGDIANGNTPSSISPSNSVGSQG-----------SGSNTPPGRIVPPDIHNMLCKQNEFLSY 1607
             .|.|..|.| .||.:||..|.|:.|           |||:.    .:|..||.|.....:..|.
Mouse  1040 SPGLGSKAVG-MPSPVSPKLSPGNSGSYSSGGSSASASGSSV----TIPQKIHQMAASYVQVTSN 1099

  Fly  1608 LNSAHELWDQADRLVRTGNHIDFIRELDHENGPLTLH-STMHEVFRYVQAGLKTLR 1662
            ...|.|:||||::|.:  ...:|..|||...|||..: |.|.::.||.:.||..||
Mouse  1100 FLYATEIWDQAEQLSK--EQKEFFAELDKVMGPLIFNASIMTDLARYTRQGLHWLR 1153

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lilli	NP_523464.1	AF-4_C	1435..1662	CDD:465894	81/249 (33%)
Aff4	NP_291043.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..42		13/31 (42%)
		AF-4	2..474	CDD:461550	133/596 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	78..289		54/248 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	322..908		191/1059 (18%)
		valS	<499..629	CDD:237855	41/245 (17%)
		PTZ00449	<554..900	CDD:185628	112/620 (18%)
		AF4_int	709..723	CDD:436798	8/13 (62%)
		AF-4_C	896..1159	CDD:465894	89/284 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1031..1070		11/39 (28%)