DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lilli and Aff4

DIOPT Version :9

Sequence 1:	NP_001137775.1	Gene:	lilli / 33496	FlyBaseID:	FBgn0041111	Length:	1673	Species:	Drosophila melanogaster
Sequence 2:	NP_291043.1	Gene:	Aff4 / 93736	MGIID:	2136171	Length:	1160	Species:	Mus musculus

Alignment Length:	1677	Identity:	361/1677 - (21%)
Similarity:	541/1677 - (32%)	Gaps:	612/1677 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 RRKRREREKIERQQGIQIDDRETSLFGEPRRLTEGD----AEITAALGEFFEAREYINNQT---- 121
            |.|.|||...|.|||.......:.||.||.::|..:    :.|.:.||.:.|.::||.:::
Mouse    10 RMKERERRNQEIQQGEDAFPPSSPLFAEPYKVTSKEDKLSSRIQSMLGNYDEMKDYIGDRSIPKL 74

  Fly   122 VGISRSA-PGAGNPRLQPNLAPQAKSLGHSPSSASSAAGPTAASATTSLPGQQQHYQQQQRPPTY 185
            |.|.:.| |...:.:..||...|.    |..|..||...|...:.:||        |.|:|  :.
Mouse    75 VAIPKPAVPTTTDEKANPNFFEQR----HGGSHQSSKWTPVGPAPSTS--------QSQKR--SS 125

  Fly   186 VKQADNKPPYNGRGG----YPGQPMKNDIPSSS------------GMAPPRGPPRTSSSNSNSSS 234
            ..|:.:....:|.||    ..||....|..|||            ..:...|.|:..||.|:|.|
Mouse   126 ALQSGHSSQRSGAGGSGASSSGQRHDRDSYSSSRKKGQHGSEHSKSRSSSPGKPQAVSSLSSSHS 190

  Fly   235 VT---NNASSGGVPASTPLGPPLSTQMP------NGREKSFLGPPAPALHNGTGGRFVPPAASKR 290
            .:   ::.|.....:.:|..|..:...|      :|:..|...|  |:|.:.:......|.|..|
Mouse   191 RSHGNDHHSKEHQRSKSPRDPDANWDSPSRGPFSSGQHSSQSFP--PSLMSKSSSMLQKPTAYVR 253

  Fly   291 PGVGQQPPPPEKDVNKIISDIANIFTVQPLTLIAATPHAPTRENYNL---LAPNRQKY--AMDIP 350
            |..||:...|     |:.|:                 |..::.:.|.   |.|:.:.:  .:.||
Mouse   254 PMDGQESVEP-----KLSSE-----------------HYSSQSHGNSMTELKPSSKAHLTKLKIP 296

  Fly   351 SSPPSAEPS---SLMTPLFAPITSPIAPLVT---TP--PQASQMPLGGATSGTILAGEALAPLHQ 407
            |.|..|..|   |.:..:...:|....|.:|   ||  .:.|:.|.
Mouse   297 SRPLDASVSGDVSCVDEILKEMTHSWPPPLTAIHTPCKTEPSKFPF------------------- 342

  Fly   408 LPPTMPKAASGVTSPGPVKPLKTEKNHSLEKQDSCLENDLELSESEDEQRKKEGRSGGNSSNSSE 472
              ||.....|.. .||..|...|.|..:..:..|.|::||:||.|||            |....:
Mouse   343 --PTKESQQSNF-GPGEQKRYSTAKTSNGHQSKSMLKDDLKLSSSED------------SDGEQD 392

  Fly   473 SDSSESGSESSSKNDLQHHPNHQQHHHQLQQQQQQQQATMQQQQVLQQQHRSQPLTSNGAQNKKF 537
            .|.:...|...|.::..||                                    .|.||.|.:
Mouse   393 CDKTMPRSTPGSNSEPSHH------------------------------------NSEGADNSR- 420

  Fly   538 RHEIIARGSNTITGLLSSSGFGSGGNVGPAGVNSNAVVGTGSGSGGTLSSGGSSSNKTPSPTESN 602
                  ..|::.:|..||||..|...              .|.|....:....|::..|.|..:|
Mouse   421 ------DDSSSHSGSESSSGSDSESE--------------SSSSDSEANEPSQSASPEPEPPPTN 465

  Fly   603 KWNLSRFFHKPANQTNSESVSPGNVSMKVPGILPGGAQIIPESIDVTTAIVKNEKNDMAMEEGEE 667
            ||.|..:.    |:.|...|||.:                  |:|
Mouse   466 KWQLDNWL----NKVNPHKVSPAS------------------SVD-------------------- 488

  Fly   668 EDDDEEQQLRYGGGLSVTPVAVKKEAIDAVSEMALGAIPKTQ-IKRESAETLLSARLSD-SGTSA 730
                                               ..||.:| .|:|..|...::..:| .||..
Mouse   489 -----------------------------------SNIPSSQAYKKEGREQGTASNYTDPGGTKE 518

  Fly   731 SGSSSSSSSSSDSAMGGEVVPMPGPGETLQLPGVPAAITTVMRVQPTQSQKAP-PSNSVTLTPIL 794
            :.|::....|.....|.|    .|.|.                      ||:| .|:|.|
Mouse   519 TSSATPGRDSKTIQKGSE----SGRGR----------------------QKSPAQSDSTT----- 552

  Fly   795 PLPTSPKQRQKKPRKKKAITSAPILDSSDDDEPPPKHPGLDHTAVSVQTQPATDTVKKGRGRPRK 859
            ...|..|::.|||.|..|            :||                          ||
Mouse   553 QRRTVGKKQPKKPEKSAA------------EEP--------------------------RG---- 575

  Fly   860 QQQSGGSGNLSSASAGSSSQTKGPTLTAAKKPLAKTPLAMSRARKREHSSQSSSNGNTPTKKVAT 924
                           |...:::.|...||..|.::...|...:||.....:|.|:.
Mouse   576 ---------------GLKIESETPVDMAASMPSSRHKAATKGSRKPNIKKESKSSP--------- 616

  Fly   925 PQLVAAPLKPTSNTAGSSSSDEDSSSSAESSSKSSSSSSSSDDTETQNTNCRIVKLNKTGAVQKK 989
                    :||:           .....:|:||.|..|....:|:|
Mouse   617 --------RPTA-----------EKKKYKSASKPSQKSREIIETDT------------------- 643

  Fly   990 ALLGSGSSSPSSSGSEAEDQTTRSQVGSGQALAQQLPPYKQLPISQHSQHLSSSDCSSSSGGCTA 1054
                   ||..|.|||:                  |||..|.|....|..             |.
Mouse   644 -------SSSDSDGSES------------------LPPSSQTPKYPESNR-------------TP 670

  Fly  1055 VCSSSSGEEDEGRREKERERKPKSDKNKINTLTRIFNPKEGGAKKQGQVVIVDLQEEQQQGKLDA 1119
            |..||..|||...|:                  |:|:|.|
Mouse   671 VKPSSVEEEDSFFRQ------------------RMFSPME------------------------- 692

  Fly  1120 AAQPSAPQAPPAAPAAIMAKPRMTPTQQQQLGAGLASPARTTTPHLTSLICKIDLSKLSRERIMR 1184
                                       :::|.:.|:.|     .....||.||||:.|:|.....
Mouse   693 ---------------------------EKELLSPLSEP-----DDRYPLIVKIDLNLLTRIPGKP 725

  Fly  1185 LKKLTPAQQNGHLTPKDQATNAVHVPNGYAGDTNPAAKVKHEHPVKPEPELDAGYEAKFKPGNVK 1249
            .|:..|        ||.:..|   ||.            ||...|:.:....|..:.|.|..|
Mouse   726 YKETEP--------PKGEKKN---VPE------------KHSREVQKQASEKASNKGKRKHKN-- 765

  Fly  1250 QEFQLKQERDRDRERERERERERERDREREQPPGRRRKRSSSSSSSPYKEKKRKKEKADQLQMGK 1314
                    .|..|..|.::.:..:::....:|...|    .||..|..||              |
Mouse   766 --------DDDTRASESKKPKTEDKNSSGHKPSSSR----ESSKQSSTKE--------------K 804

  Fly  1315 ELLPVPV--LLPSNNHERMPNHDRLSYDKLQLLHEDAAAVIGDVSAPNGSPTKKLLAMSPLPPPP 1377
            :|||.|.  :|..::.....:..|.......|...      |..|..|...:.|..:.|......
Mouse   805 DLLPSPAGPILSKDSKTEHGSRKRTVSQSSSLKSS------GTSSKENSGSSSKSSSSSTAKQKK 863

  Fly  1378 TVTVAPATCNEAVQTTP------PSATATSAIAPPVPATRLIY--RSYFDRDVEHPSDDPRKNNQ 1434
            |....|::..||.:..|      |.:|.||..:.| ..|:|.:  |:|   ..:|
Mouse   864 TEGKGPSSSKEAKEKAPNSSSNCPPSTPTSESSKP-RRTKLAFDDRNY---SADH---------- 914

  Fly  1435 FLQEAINRKHAADLERDSFNQVTLYLEAVVYFLLTADAMERCSSE-QATNTMYKDTLSLIKFIST 1498
            :||||...||.||...|.|.:...||:|||.|:...:|:|:.:.| ::...||.||:.|||: :.
Mouse   915 YLQEAKKLKHNADALSDRFEKAVYYLDAVVSFIECGNALEKNAQESKSPFPMYSDTVELIKY-TM 978

  Fly  1499 KFRPYQQQSTTNIQHETHNKVAILSLRCQSLISLKLYKLRRKDCRAIINSLTDFFR--------- 1554
            |.:.|.....|    ....::.:|.||||||:.|:|:||::::......:||:..:
Mouse   979 KLKNYLAPDAT----AADKRLTVLCLRCQSLLYLRLFKLKKENALKYSKTLTEHLKNSYSNSQAP 1039

  Fly  1555 -VGRGDIANGNTPSSISPSNSVGSQGS----GSNTPPGR---IVPPDIHNMLCKQNEFLSYLNSA 1611
             .|.|..|.| .||.:||..|.|:.||    ||:.....   .:|..||.|.....:..|....|
Mouse  1040 SPGLGSKAVG-MPSPVSPKLSPGNSGSYSSGGSSASASGSSVTIPQKIHQMAASYVQVTSNFLYA 1103

  Fly  1612 HELWDQADRLVRTGNHIDFIRELDHENGPLTLH-STMHEVFRYVQAGLKTLR 1662
            .|:||||::|.:  ...:|..|||...|||..: |.|.::.||.:.||..||
Mouse  1104 TEIWDQAEQLSK--EQKEFFAELDKVMGPLIFNASIMTDLARYTRQGLHWLR 1153

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lilli	NP_001137775.1	AF-4	<1435..1662	CDD:282905	81/245 (33%)
Aff4	NP_291043.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..42		13/31 (42%)
		AF-4	3..1156	CDD:368289	361/1677 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	78..289		54/248 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	322..908		191/1059 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1031..1070		12/39 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837796
Domainoid	1	1.000	131	1.000	Domainoid score	I5113
eggNOG	1	0.900	-	-		E1_28IRS
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	167	1.000	Inparanoid score	I4158
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001371
OrthoInspector	1	1.000	-	-		otm43774
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10528
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4465
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.010