Protein Alignment lilli and AFF1

DIOPT Version :10

• Sequence 1: NP_523464.1
• Gene: lilli / 33496
• FlyBaseID: FBgn0041111
• Length: 1673
• Species: Drosophila melanogaster
• Sequence 2: NP_001160165.1
• Gene: AFF1 / 4299
• HGNCID: 7135
• Length: 1218
• Species: Homo sapiens
• Alignment Length: 1782
• Identity: 352/1782 - (19%)
• Similarity: 540/1782 - (30%)
• Gaps: 725/1782 - (40%)

  Fly    44 DQLQQYNNNLYSQNYNMEEYERRKRREREKIERQQGIQIDDRETSLFGEPRRLTEGD---AEITA 105
            :::....|:||:.:.|:.....::||.:|..:.::..   ..:..|||||.:..:||   :.|..
Human     5 ERVNSSGNSLYNDDRNLLRIREKERRNQEAHQEKEAF---PEKIPLFGEPYKTAKGDELSSRIQN 66

  Fly   106 ALGEFFEAREYIN--NQTVGISRSAPGAGNPRLQPNLAPQAKSLG--------HSPSSASSAAGP 160
            .||.:.|.:|:::  :.|..:..|....|.|: .|.:..:..|:.        |..|..:.|:||
Human    67 MLGNYEEVKEFLSTKSHTHRLDASENRLGKPK-YPLIPDKGSSIPSSSFHTSVHHQSIHTPASGP 130

  Fly   161 TAASATTSLPGQQQHYQQQQRPPTYVKQADNKPPYN--------GRGGYPGQPMKN--------- 208
            .:....:..|...|. :.:..|..:.|...  ||.:        |:.|:.....|.
Human   131 LSVGNISHNPKMAQP-RTEPMPSLHAKSCG--PPDSQHLTQDRLGQEGFGSSHHKKGDRRADGDH 192

  Fly   209 -----------------DIPSSSGMAPPRGP--------PRTSSSNSNSSSVTNNASSGGVPAST 248
                             .:||.   .||..|        |||..|:....|  :|.|.|..||.:
Human   193 CASVTDSAPERELSPLISLPSP---VPPLSPIHSNQQTLPRTQGSSKVHGS--SNNSKGYCPAKS 252

  Fly   249 PLGPPLSTQMPNGREKSFLGP--------PAPALHNGTGGRFVPPAASKRPGVGQQPPPPEKDVN 305
            |....:........:.|.:.|        |.|:|.:.:......|.|..||..||...|.|....
Human   253 PKDLAVKVHDKETPQDSLVAPAQPPSQTFPPPSLPSKSVAMQQKPTAYVRPMDGQDQAPSESPEL 317

  Fly   306 KIISDIANIFTVQPLTLIAATPHAPTRENYNLLAPNRQKYAMDIPSSPPSAEPSSLMTPLFAPIT 370
            |                       |..|:|      ||:          :.|.:.|..|..|.:|
Human   318 K-----------------------PLPEDY------RQQ----------TFEKTDLKVPAKAKLT 343

  Fly   371 SPIAPLVTTPPQASQMPLGGATSGTILAGEALAPL-HQLPPTM-----PKAASGVTSPGPVKPLK 429
            .     :..|.|:.:........   ...|.|..: |..||.:     |..|.....|.|.|..:
Human   344 K-----LKMPSQSVEQTYSNEVH---CVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQ 400

  Fly   430 --------------TEKNHSLEKQ--DSCLENDLELSESEDEQRKKEGRSGGNSSNSSESDSSES 478
                          :.|.||..:|  .|.||:||:||:|||
Human   401 HVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSED------------------------ 441

  Fly   479 GSESSSKNDLQHHPNHQQHHHQLQQQQQQQQATMQQQQVLQQQHRSQPLTSNGAQNKKFRHEIIA 543
                                                                             
Human   442 ----------------------------------------------------------------- 441

  Fly   544 RGSNTITGLLSSSGFGSGGNVGPAGVNSNAVVGTGSGSGGTLSSGGSSSNKTPSPTESNKWNLSR 608
                                                          |.|.:||
Human   442 ----------------------------------------------SDSEQTP------------ 448

  Fly   609 FFHKPANQTNSESVSPGNVSMKVPGILPGGAQIIPESIDVTTAIVKNEKNDMAMEEGEEEDDDEE 673
              .||.:     |.:|           |...|.:||
Human   449 --EKPPS-----SSAP-----------PSAPQSLPE----------------------------- 466

  Fly   674 QQLRYGGGLSVTPVAVKKEAIDAVSEMALGAIPKTQIKRESAETLLSARLSDSGTSASGSSSSSS 738
                        |||      .|.|..|           ||..|      |||.:|:...|.|||
Human   467 ------------PVA------SAHSSSA-----------ESEST------SDSDSSSDSESESSS 496

  Fly   739 SSSDSAMGGEVVPMPGPGETLQLPGVPAA--------ITTVMRVQPTQSQKAPPSNSVTLTPILP 795
            |.|:.   .|.:..|.|.     |..|..        :|.|.  ||.    |||..        |
Human   497 SDSEE---NEPLETPAPE-----PEPPTTNKWQLDNWLTKVS--QPA----APPEG--------P 539

  Fly   796 LPTSPKQRQKKPRKKKAITSAPILDSSDDDEPPPK-------------HPGLD--HTAVSVQTQP 845
            ..|.|.:|.  |..|.:..||...:.|:..:||||             |||..  ..:.:.|..|
Human   540 RSTEPPRRH--PESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPP 602

  Fly   846 ATDTVKKGRGRPRKQQQSGGSGNLSSASAGSSSQTKG---PTL--------TAAKKPLAKTPLAM 899
            ...||  |..:|:|..:       :||.|||.:..:|   |.|        |:..||..||
Human   603 QRQTV--GTKQPKKPVK-------ASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKT---- 654

  Fly   900 SRARKREHSSQSSSNGNTPTKKVATPQLVAAPLKPTSNTAGSSSSDEDSSSSAESSSKSSSSSSS 964
             :.|.|..:|      |.|  |.|.|                       .||.:...|||..:.|
Human   655 -KGRPRAAAS------NEP--KPAVP-----------------------PSSEKKKHKSSLPAPS 687

  Fly   965 SDDTETQNTNCRIVKLNKTGAVQKKALLGSGSSSPSSSGSEAEDQTTRSQVGSGQALAQQLPPYK 1029
                                    |||     |.|..:....||:|...              :.
Human   688 ------------------------KAL-----SGPEPAKDNVEDRTPEH--------------FA 709

  Fly  1030 QLPISQHSQHLSSSDCSSSSGGCTAVCSSSSGEEDEGRREKERERKPKSDKNKINTLTRIFNPKE 1094
            .:|::: ||....|...|.:.||.
Human   710 LVPLTE-SQGPPHSGSGSRTSGCR----------------------------------------- 732

  Fly  1095 GGAKKQGQVVIVDLQEEQQQGKLDAAAQPSAPQAPPAAPAAIMAKPRMTPTQQQQLGAGLASPAR 1159
                   |.|:|  ||:.::.:|....:.:.                            |.||.|
Human   733 -------QAVVV--QEDSRKDRLPLPLRDTK----------------------------LLSPLR 760

  Fly  1160 TTTPHLTSLICKIDLSKLSRERIMRLKKLTPAQQNGHLTPKDQATNAVHVPNG------YAGDTN 1218
            .|.|. .||:.||.|..|||                           :..|.|      .|.|..
Human   761 DTPPP-QSLMVKITLDLLSR---------------------------IPQPPGKGSRQRKAEDKQ 797

  Fly  1219 PAAKVKHEHPVKPEPELDAGYEAKFKPGNVKQEFQLKQERDRDRERERERERERERDREREQPPG 1283
            |.|..||...                          |:..|...:..::|:.|.|||.:.::...
Human   798 PPAGKKHSSE--------------------------KRSSDSSSKLAKKRKGEAERDCDNKKIRL 836

  Fly  1284 RRR-KRSSSSSSSPYKEKKRKKEKADQLQMG-KELLPVPVLLPSNNHERMPNHDRLSYDKLQLLH 1346
            .:. |..||||||.:||..:.|......|.. ||:||.|   |.::..:.|....|...:.:
Human   837 EKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPP---PVSSSSQKPAKPALKRSRRE--- 895

  Fly  1347 EDAAAVIGDVSAPNGSPTKKLLAMSPLPPPPTVTVAPATCNEAVQTTPPSATATSAIAPPVPATR 1411
               |...|.....:.|.||.....|.:|....|.      .:..:::.....::...|.|.|...
Human   896 ---ADTCGQDPPKSASSTKSNHKDSSIPKQRRVE------GKGSRSSSEHKGSSGDTANPFPVPS 951

  Fly  1412 LIYRSYFDRDVEHPSD-----------DPRKNNQFLQEAINRKHAADLERDSFNQVTLYLEAVVY 1465
            |            |:.           |.::.:..::||...|..|:|..|...:...|||||:.
Human   952 L------------PNGNSKPGKPQVKFDKQQADLHMREAKKMKQKAELMTDRVGKAFKYLEAVLS 1004

  Fly  1466 FLLTADAME-RCSSEQATNTMYKDTLSLIKFISTKFRPYQQQSTTNIQHETHNKV-AILSLRCQS 1528
            |:....|.| ...|.::..::|.:|:.|||||.:      .:|.::....|..|: |:|.:||||
Human  1005 FIECGIATESESQSSKSAYSVYSETVDLIKFIMS------LKSFSDATAPTQEKIFAVLCMRCQS 1063

  Fly  1529 LISLKLYKLRR----KDCRAIINSLTDFFRVGRGD---IANG-NTPSSI----SPSNSVGSQGS- 1580
            ::::.:::.::    |..|.:........:|.:..   ||.. .|||.:    ||::|||||.|
Human  1064 ILNMAMFRCKKDIAIKYSRTLNKHFESSSKVAQAPSPCIARSTGTPSPLSPMPSPASSVGSQSSA 1128

  Fly  1581 ---GSNTPPGRI-VPPDIHNMLCKQNEFLSYLNSAHELWDQADRLVRTGNHIDFIRELDHENGPL 1641
               ||:.....| .|..|.||........|::.:|.:||:||:.|.|...  :|...|......|
Human  1129 GSVGSSGVAATISTPVTIQNMTSSYVTITSHVLTAFDLWEQAEALTRKNK--EFFARLSTNVCTL 1191

  Fly  1642 TLHSTMHEVFRYVQAGLKTLRDAVSHP 1668
            .|:|::.::..|.:.|.:.|::....|
Human  1192 ALNSSLVDLVHYTRQGFQQLQELTKTP 1218

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lilli	NP_523464.1	AF-4_C	1435..1662	CDD:465894	69/245 (28%)
AFF1	NP_001160165.1	AF-4	15..527	CDD:461550	139/807 (17%)
		PHA03247	<533..800	CDD:223021	93/475 (20%)
		AF-4_C	957..1218	CDD:465894	71/268 (26%)