Protein Alignment lilli and AFF3

DIOPT Version :9

• Sequence 1: NP_001137775.1
• Gene: lilli / 33496
• FlyBaseID: FBgn0041111
• Length: 1673
• Species: Drosophila melanogaster
• Sequence 2: XP_024308651.1
• Gene: AFF3 / 3899
• HGNCID: 6473
• Length: 1380
• Species: Homo sapiens
• Alignment Length: 1731
• Identity: 369/1731 - (21%)
• Similarity: 582/1731 - (33%)
• Gaps: 575/1731 - (33%)

  Fly    24 NSSSIVLLQQQQPQQQQQQLDQLQQYNNNLY-----SQNYNMEEYE------RRKRREREKIERQ 77
            :|..:.|||:...:....: |.|.|.|::|.     |.:.....||      |||.|||...|.|
Human   131 DSFDLALLQEWDLESLWGE-DILNQRNDSLVVEFQSSASRCRSVYEPDRNALRRKERERRNQETQ 194

  Fly    78 QGIQIDDRETSLFGEPRRLTEGDA---EITAALGEFFEAREYI---NNQT--VGISRSAPGAGNP 134
            |.....:...|||.||.:..:||.   .|...||.:.|.::::   :||:  ||:    |..|.|
Human   195 QDDGTFNSSYSLFSEPYKTNKGDELSNRIQNTLGNYDEMKDFLTDRSNQSHLVGV----PKPGVP 255

  Fly   135 RLQPNLAPQAKSLGHSPSSASSAAGPTA-ASATTSLPGQQQHYQQQQRPPTYVKQADNKPPYNGR 198
            :     .|..|...|..:.:.:...|:: .|.|||.|.... .||.:|               |.
Human   256 Q-----TPVNKIDEHFVADSRAQNQPSSICSTTTSTPAAVP-VQQSKR---------------GT 299

  Fly   199 GGYPGQPMKNDIPSSSGMAPPRGPPRTSSSNSNSSSVTNNASSGGVPASTPLGPPLSTQMPNGRE 263
            .|:          ..:|..|..|..|.:...|               ..|.||..:..|.|..::
Human   300 MGW----------QKAGHPPSDGQQRATQQGS---------------LRTLLGDGVGRQQPRAKQ 339

  Fly   264 --------KSFLGPPAPALHNGTGGRFV---PPAASKRPGVGQQPPPPEKDVNKIISDIANIFTV 317
                    ::...|||.|..:.:.|..|   ||:.:.:|.:.||.|..               .|
Human   340 VCNVEVGLQTQERPPAMAAKHSSSGHCVQNFPPSLASKPSLVQQKPTA---------------YV 389

  Fly   318 QPLTLIAATP-HAPTRENYNLLAPNRQKYAMDIPSSPPSAEPSSLMTPLFAPITSPIAPLVTTPP 381
            :|:......| .:|..::.:..:.:...| ..:|:|.|  ||:.....|         ...:.|.
Human   390 RPMDGQDQAPDESPKLKSSSETSVHCTSY-RGVPASKP--EPARAKAKL---------SKFSIPK 442

  Fly   382 QASQMPLGGATSGTILAGEALAPLHQLPPTMPKAASGVTSPGPVKPLKTEKNHSLEKQDSCLEND 446
            |..:...|...|   ...|.:..:..|||     .|.:.:||.|:|.|    .....:||.|.:
Human   443 QGEESRSGETNS---CVEEIIREMTWLPP-----LSAIQAPGKVEPTK----FPFPNKDSQLVS- 494

  Fly   447 LELSESEDEQRKKEGRSGGNS--SNSSESDSSESGSESSS--KNDLQHHPNHQQHHHQLQQQQQQ 507
                            ||.|:  ...:|.:|.::|:.::|  ::||:...:.:::    :||..|
Human   495 ----------------SGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEEN----EQQAAQ 539

  Fly   508 QQA--TMQQQQVLQQQHRSQPLTSNGAQNKKFRHEIIARGSNTITGLLSSSGFGSGGNVGPAGVN 570
            :.|  .:....|:||                         .|..|.:.||.|..|..:.|.:..:
Human   540 RTALRALSDSAVVQQ-------------------------PNCRTSVPSSKGSSSSSSSGSSSSS 579

  Fly   571 SNAVVGTGSGSGGTLSSGGSSSNKTP-------SPTESNKWNLSRFFHKPANQTNSESVSPGNVS 628
            |::...:||.|....||..|..:|.|       .|..||||.|.::.:|         |:|..
Human   580 SDSESSSGSDSETESSSSESEGSKPPHFSSPEAEPASSNKWQLDKWLNK---------VNPHK-- 633

  Fly   629 MKVPGILPGGAQIIPESIDVTTAIVKNEKNDMAMEEGEEEDDDEEQQLRYGGGLSVTPVAVKKEA 693
               |.||                 ::||.:      |.|.:       :|     ..||....:.
Human   634 ---PPIL-----------------IQNESH------GSESN-------QY-----YNPVKEDVQD 660

  Fly   694 IDAVSEMALGAIPKTQIKRESAETLLSARLSDSGTSASGSSSSSSSSSDSAMGGEVVPMPGPGET 758
            ...|.::...::.:.:||    .|....:...:...|.||......|..:|:...|.....|
Human   661 CGKVPDVCQPSLREKEIK----STCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPP--- 718

  Fly   759 LQLPGVPAAITTVMRVQPTQSQKAPPSNSVTLTPILPLPTSPKQRQKKPRKKKAITSAPILDSSD 823
               |.||.|        |.::..||...|.               .|||.::...|||
Human   719 ---PAVPCA--------PAENAPAPARRSA---------------GKKPTRRTERTSA------- 750

  Fly   824 DDEPPPKHPGLDHTAVSVQTQPATDTVKKGRGRPRKQQQSGGSGNLSSASAGSSSQTKGPTLTAA 888
                                                    |...|.......:::...|.::...
Human   751 ----------------------------------------GDGANCHRPEEPAAADALGTSVVVP 775

  Fly   889 KKPLAKTPLAMSRARKREHSSQSSSNGNTPTKKVATPQLVAAPLKPTSNTAGSSSSDEDSSSSAE 953
            .:|....|...:||..|:....|.    |..|:               .|.|.|.....|....|
Human   776 PEPTKTRPCGNNRASHRKELRSSV----TCEKR---------------RTRGLSRIVPKSKEFIE 821

  Fly   954 SSSKSSSSSSSSD-DTETQNTNCRIVKLNKTGAVQKKALLGSGSSSPSSSGSEAEDQTTRSQVGS 1017
            :.|.||||||.|| ::|.:.     ..|:|.                         ||..:...|
Human   822 TESSSSSSSSDSDLESEQEE-----YPLSKA-------------------------QTVAASASS 856

  Fly  1018 GQALAQQLPPYKQLPISQHSQHLSSSDCSSSSGGCTAVCSSSSGEEDEGRREKERERKPKSDKNK 1082
            |                 :.|.|..:..:..||                         |::....
Human   857 G-----------------NDQRLKEAAANGGSG-------------------------PRAPVGS 879

  Fly  1083 INTLTRIFNPKEGGAKKQGQVVIVDLQEEQQQGKLDAAAQPSAPQAPPAAPAAIMAKPRMTPTQQ 1147
            ||..|.....||              .|||..                          .:.|..:
Human   880 INARTTSDIAKE--------------LEEQFY--------------------------TLVPFGR 904

  Fly  1148 QQLGAGLASPARTTTPHLTSLICKIDLSKLSRERIMRLKKLTPAQQNGHLTPKDQATNAVHVPNG 1212
            .:    |.||.: .:..:.||..||||:.|||                  .|:       |:|..
Human   905 NE----LLSPLK-DSDEIRSLWVKIDLTLLSR------------------IPE-------HLPQE 939

  Fly  1213 YAGDTNPAAKVKHEHPVKPEPELDAGYEAKFKPGNVKQEFQLKQERDRDRERERERERERERD-R 1276
            ....:.||.|.....|  |....|...| |..|                 :.:|:|:.:.|.| |
Human   940 PGVLSAPATKDSESAP--PSHTSDTPAE-KALP-----------------KSKRKRKCDNEDDYR 984

  Fly  1277 EREQPPGRRRKRSSSSSSSPYKEKKRKKEKADQLQMGKELLPVPVLLPSNNHERM---PNHDRLS 1338
            |.::..|.:      .|||...........|:...|....:.:|:    |.:|:|   |......
Human   985 EIKKSQGEK------DSSSRLATSTSNTLSANHCNMNINSVAIPI----NKNEKMLRSPISPLSD 1039

  Fly  1339 YDKLQLLHEDAAAVIGDVSAPNG-------SPTKKLLAMSPLPP-PPTVTVAPATCNEAV----- 1390
            ..|.:...||    :...|.|||       |.:||..|.|.|.| ...:|.|....:|.:
Human  1040 ASKHKYTSED----LTSSSRPNGNSLFTSASSSKKPKADSQLQPHGGDLTKAAHNNSENIPLHKS 1100

  Fly  1391 --QTTPPSATATSAIAPPVPATRLIYRSYFDRDVEHP----SDDPRKNNQFLQEAINRKHAADLE 1449
              ||.|.|..:..                 .||.:..    .|.||..:.|:|||...||.||..
Human  1101 RPQTKPWSPGSNG-----------------HRDCKRQKLVFDDMPRSADYFMQEAKRMKHKADAM 1148

  Fly  1450 RDSFNQVTLYLEAVVYFLLTADAMERCSSE-QATNTMYKDTLSLIKFISTKFRPYQQQSTTNIQH 1513
            .:.|.:...|.||.:.|:...:|||:...| ::..|||.:|:.||:: :.:.:.:...:.|
Human  1149 VEKFGKALNYAEAALSFIECGNAMEQGPMESKSPYTMYSETVELIRY-AMRLKTHSGPNAT---- 1208

  Fly  1514 ETHNKVAILSLRCQSLISLKLYKLRRKDCRAIINSLTDFFR-----------VGRGDIANGNTPS 1567
            ....::|.|..||.:|:..::::|:|........:|.|:|:           .|....:.| |||
Human  1209 PEDKQLAALCYRCLALLYWRMFRLKRDHAVKYSKALIDYFKNSSKAAQAPSPWGASGKSTG-TPS 1272

  Fly  1568 SI----SPSNSVGSQGSGSNT---PPGRIV--PPDIHNMLCKQNEFLSYLNSAHELWDQADRLVR 1623
            .:    ||::|||||||.||.   .|..||  |..||.|........:.:..:::.|:.||.|.:
Human  1273 PMSPNPSPASSVGSQGSLSNASALSPSTIVSIPQRIHQMAANHVSITNSILHSYDYWEMADNLAK 1337

  Fly  1624 TGNHIDFIRELDHENGPLTLHSTMHEVFRYVQAGLKTLRDA 1664
            ...  :|..:||...||:||||:|..:.:|.|.||..||::
Human  1338 ENR--EFFNDLDLLMGPVTLHSSMEHLVQYSQQGLHWLRNS 1376

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lilli	NP_001137775.1	AF-4	<1435..1662	CDD:282905	75/247 (30%)
AFF3	XP_024308651.1	AF-4	177..1374	CDD:310000	355/1680 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147716
Domainoid	1	1.000	131	1.000	Domainoid score	I5139
eggNOG	1	0.900	-	-		E1_28IRS
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	155	1.000	Inparanoid score	I4312
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001371
OrthoInspector	1	1.000	-	-		otm41726
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10528
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.980