DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lilli and Aff3

DIOPT Version :9

Sequence 1:	NP_001137775.1	Gene:	lilli / 33496	FlyBaseID:	FBgn0041111	Length:	1673	Species:	Drosophila melanogaster
Sequence 2:	XP_038939770.1	Gene:	Aff3 / 363220	RGDID:	1308527	Length:	1262	Species:	Rattus norvegicus

Alignment Length:	1744	Identity:	375/1744 - (21%)
Similarity:	606/1744 - (34%)	Gaps:	578/1744 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 NSSSIVLLQQQQPQQQQQQLDQLQQYNNNLY-----SQNYNMEEYE------RRKRREREKIERQ 77
            :|..:.|||:...:....: |.|.|.|::|.     |.:.....||      |||.|||...|.|
  Rat     2 DSFDLALLQEWDLESLWGE-DILSQRNDSLVLEFQASASRCRSVYEPDRNALRRKERERRSQETQ 65

  Fly    78 QGIQIDDRETSLFGEPRRLTEGDA---EITAALGEFFEAREYI---NNQT--VGISRSAPGAGNP 134
            |.....:...|||.||.:..:||.   .|...||.:.|.::::   :||:  ||:    |..|.|
  Rat    66 QDSGGFNSGYSLFSEPYKTNKGDELSNRIQNTLGNYDEMKDFLTDRSNQSHLVGV----PKPGVP 126

  Fly   135 RLQPNLAPQ---AKSLGH-SPSSASSAAGPTAASATTSLPGQQQHYQQQQRPPTYVKQADNKPPY 195
            :...|....   |:|... .|||..|.|..|.|:...          ||.:..|...|....||.
  Rat   127 QTPVNKIDDHFVAESRAQPQPSSVCSTASSTPAAVPV----------QQSKRGTMGWQKAGHPPS 181

  Fly   196 NGRGGYPGQPMKNDIPSSSGMAPPRGPPRTSSSNSNSSSVTN-----NASSGGVPASTPLGPPLS 255
            :|:                ..|..:|..||...:......|.     |..:|           |.
  Rat   182 DGQ----------------QRAAQQGSLRTLLGDGVGRQQTRAKQVCNVETG-----------LQ 219

  Fly   256 TQMPNGREKSFLGPPAPALHNGTGGRFV---PPAASKRPGVGQQPPPPEKDVNKIISDIANIFTV 317
            ||     |:    |||.|..:..||..|   ||:.:.:|.:|||.|..               .|
  Rat   220 TQ-----ER----PPAMAAKHSGGGHCVQNFPPSLASKPSLGQQKPTA---------------YV 260

  Fly   318 QPLTLIAATPHAPTRENYNLLAPNRQKYAMDIPSSPPSAEPSSLMTPLFAPITSPIAPLVTTPPQ 382
            :|:.   ....||. |:..|.:..............|:.:|.|      |.....:|.. :.|.|
  Rat   261 RPMD---GQDQAPD-ESPKLKSSTETAVHCTAYRGVPAGKPES------ARAKGKLAKF-SIPKQ 314

  Fly   383 ASQMPLGGATSGTILAGEALAPLHQLPPTMPKAASGVTSPGPVKPLKTEKNHSLEKQDSCLENDL 447
            ..:...|...|   ...|.:..:..|||     .|.:.:|..|:|.|..
  Rat   315 GEENRSGETNS---CVEEIIREMTWLPP-----LSAIQAPAKVEPSKFP---------------- 355

  Fly   448 ELSESEDEQRKKEGRSGGNSSNSSESDSSESGSESSS--KNDLQHHPNHQQHHHQLQQQQQQQQA 510
              ..::|.|....|.|....:: :|.:|.::|:.::|  ::||:...:.:      :.:||..|.
  Rat   356 --FPNKDSQLVSSGHSNPKKAD-AEPESPDNGTSNTSTLEDDLKLSSDDE------EGEQQAAQR 411

  Fly   511 T----MQQQQVLQQQHRSQPLTSNGAQNKKFRHEIIARGSNTITGLLSSSGFGSGGNVGPAGVNS 571
            |    :....|:||.:                    .|||..     ||.|..|......:..:|
  Rat   412 TVLRALADSSVVQQTN--------------------CRGSAP-----SSKGSSSSSGGSSSSSDS 451

  Fly   572 NAVVGTGSGSGGTLSSGGSSSNKTP-------SPTESNKWNLSRFFHKPANQTNSESVSPGNVSM 629
            .:..|:.|.:..:.|...|..:|.|       .|..||||.|.::.:|         |:|..
  Rat   452 ESTSGSDSETESSSSESESEGSKPPHCSSPEAEPASSNKWQLDKWLNK---------VNPHK--- 504

  Fly   630 KVPGILPGGAQIIPESIDVTTAIVKNEKNDMAMEEGEEEDDDEEQQLRYGGGLSVTPVAVKKEAI 694
              |.||                 ::||.:      |.|.:       :|     .||  ||.|..
  Rat   505 --PPIL-----------------IQNESH------GPERN-------QY-----YTP--VKDEGQ 530

  Fly   695 DAVSEMALGAIPKTQIKRESAETLLSARLSDSGTSASGSSSSSSSSSDSAMGGEVVPMPGPGETL 759
            |.      |.:|:          :..|.|.|.....:.....
  Rat   531 DC------GKLPE----------ICQASLRDKELKTACKEEQ----------------------- 556

  Fly   760 QLPGVPAAITTVMRVQPTQSQKAPPSNSVTLTPILPLPTSPKQRQKKPRKKKAITSAPILDSSDD 824
                           :|..:.|.|.|.||              :||.|....|:|:|
  Rat   557 ---------------RPRTANKVPGSKSV--------------KQKSPPAAVAVTAA-------- 584

  Fly   825 DEPPPKHPGLDHTAVSVQTQPATDTVKKGRGRPRKQQQSGGSGNLSSASAGSSSQTKGPTLTAAK 889
             .|||..|     :...::.||......|:...|:.:::         |||.|:....|     :
  Rat   585 -APPPAVP-----SAPTESAPAPTRRSAGKKPTRRTERT---------SAGDSANCHRP-----E 629

  Fly   890 KPLAKTPLAMSRARKRE-HSSQSSSNGNTPTKKVATPQLVAAPLKPTSNTAGSSSSDEDSSSSAE 953
            :|:|...|..|.....| ..::...|..|..:|    :|.::.......|.|.|.....|....|
  Rat   630 EPVAPDALGASVVGPLEPPKTRPCGNSRTGHRK----ELRSSVTCEKRRTRGLSRIVPKSKEFIE 690

  Fly   954 SSSKSSSSSSSSDDTETQNTNCRIVKLNKTGAVQKKALLGSGSSSPSSSGSEAEDQTTRSQVGSG 1018
            :.| |||||||..|.|::               |::.:|   |.:||::|||
  Rat   691 TES-SSSSSSSDSDLESE---------------QEEYIL---SKAPSTTGSE------------- 723

  Fly  1019 QALAQQLPPYKQLPISQHSQHLSSSDCSSSSGGCTAVCSSSSGEEDEGRREKERERKPKSDKNKI 1083
            |.|.:..           |.:.|||:.||||...::..||:|                ::....|
  Rat   724 QRLKEAT-----------SNNSSSSNSSSSSSSSSSSSSSTS----------------RASVGSI 761

  Fly  1084 NTLTRIFNPKEGGAKKQGQVVIVDLQEEQQQGKLDAAAQPSAPQAPPAAPAAIMAKPRMTPTQQQ 1148
            |..|.....||              .|||..                          .:.|..:.
  Rat   762 NARTTSDIAKE--------------LEEQFY--------------------------TLVPFGRN 786

  Fly  1149 QLGAGLASPARTTTPHLTSLICKIDLSKLSR--ERIMRLKKL--TPAQQNGHLTPKDQATNAVHV 1209
            :    |.||.: .:..:.||..||||:.|||  |.:.:...:  .||.::...||   |::|:..
  Rat   787 E----LLSPLK-DSDEVRSLWVKIDLTLLSRIPEHLSQEPGVLSAPAAKDTDSTP---ASHALDT 843

  Fly  1210 PNGYAGDTNPAAKVKHEHPVKPEPELDAGYEAKFKPGNVKQEFQLKQERDRDRERERERERERER 1274
            |   |..|.|.:|                                           |:|:.:.|.
  Rat   844 P---AEKTLPKSK-------------------------------------------RKRKCDNED 862

  Fly  1275 D-REREQPPGRRR--KRSSSSSSSPYKEKKRKKEKADQLQMGKELLPVPVLLPSNNHERM----- 1331
            | ||.::..|::.  .|.::|:::.:        ......:....|.:|:    |.:|:|
  Rat   863 DYREIKKAQGKKEGASRLAASTNNTF--------SGSHCNVSINSLAIPI----NKNEKMLRSPS 915

  Fly  1332 -PNHDRLSYDKLQLLHEDAAAVIGDVSAPNGSPTKKLLAMSPLPPPPTVTVAPATCNEAVQTTPP 1395
             |..|...       |:.::..:...|.|:|:..  |.::|....|...:...:...:..:.:..
  Rat   916 SPLSDACK-------HKYSSEDVTSSSRPHGNGL--LTSVSSNKEPKAESQLQSHAGDLTKISHN 971

  Fly  1396 SATATSAIAPPVPAT----------------RLIYRSYFDRDVEHPSDDPRKNNQFLQEAINRKH 1444
            |:......:...|.|                :||:           .|.||..:.|::||...||
  Rat   972 SSENGILHSKSRPQTEPWSPGSNGHRDCKRQKLIF-----------DDMPRSADYFMREAKRMKH 1025

  Fly  1445 AADLERDSFNQVTLYLEAVVYFLLTADAMERCSSE-QATNTMYKDTLSLIKFISTKFRPYQQQST 1508
            .||...:.|.:...|.||.:.|:...:|||:...| ::..|||.:|:.||:: :.:.:.:...:.
  Rat  1026 KADAMVEKFGKALNYAEAALSFIECGNAMEQGPMESKSPYTMYSETVELIRY-AMRLKTHSGPNA 1089

  Fly  1509 TNIQHETHNKVAILSLRCQSLISLKLYKLRRKDCRAIINSLTDFFR-----------VGRGDIAN 1562
            |    ....::|.|..||.:|:..::::|:|........:|.|:|:           .|....:.
  Rat  1090 T----PEDKQLAALCYRCLALLYWRMFRLKRDHAVKYSKALIDYFKNSSKAAQAPSPWGSSGKST 1150

  Fly  1563 GNTPSSI----SPSNSVGSQG---SGSNTPPGRIV--PPDIHNMLCKQNEFLSYLNSAHELWDQA 1618
            | :||.:    ||::||||||   |.|...|..||  |..||.|........:.:..:::.|:.|
  Rat  1151 G-SPSPMSPNPSPASSVGSQGSLSSSSGLSPSTIVSIPQRIHQMAANHVSITNSILHSYDYWEMA 1214

  Fly  1619 DRLVRTGNHIDFIRELDHENGPLTLHSTMHEVFRYVQAGLKTLRDAVSHPTHQS 1672
            |.|.:...  :|..:||...||:||||:|..:.:|.|.||..||.:    ||.|
  Rat  1215 DNLAKENR--EFFNDLDLLMGPVTLHSSMEHLVQYSQQGLHWLRSS----THLS 1262

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lilli	NP_001137775.1	AF-4	<1435..1662	CDD:282905	72/247 (29%)
Aff3	XP_038939770.1	AF-4	45..498	CDD:398672	132/586 (23%)
Aff3	XP_038939770.1	AF-4_C	1001..1261	CDD:408646	80/282 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341544
Domainoid	1	1.000	132	1.000	Domainoid score	I4970
eggNOG	1	0.900	-	-		E1_28IRS
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I4034
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001371
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10528
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.980