DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lilli and Aff1

DIOPT Version :9

Sequence 1:	NP_001137775.1	Gene:	lilli / 33496	FlyBaseID:	FBgn0041111	Length:	1673	Species:	Drosophila melanogaster
Sequence 2:	XP_038947749.1	Gene:	Aff1 / 305152	RGDID:	1307940	Length:	1228	Species:	Rattus norvegicus

Alignment Length:	1774	Identity:	349/1774 - (19%)
Similarity:	530/1774 - (29%)	Gaps:	721/1774 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 LYSQNYNMEEYERRKRREREKIERQQGIQIDDRETSLFGEPRRLTEGD---AEITAALGEFFEAR 114
            ||:::.|:.....::||.:|..:.::..   ..:..||.||.:..:||   :.|...||::.|.:
  Rat    16 LYNEDRNLLRIREKERRNQEAHQEKEAF---PEKAPLFAEPYKTAKGDELSSRIQTMLGDYEEMK 77

  Fly   115 EYINNQT----VGISRSAPGAGNPRLQPNLAPQAKSLGHSPSSASSAAGPTAASAT--------T 167
            |::::::    :..|...|  |.||.              ||.....:|.:.:..|        |
  Rat    78 EFLSSKSHPHRLDGSEDRP--GKPRY--------------PSCHDRGSGASGSFRTHVYHQPTHT 126

  Fly   168 SLPGQQQHYQQQQRPPTYVKQADNKPPYNGRGGYPGQPMKNDIPSSSGM---AP--PRGPPRTSS 227
            |.||........|.|    |.|              ||....:||....   ||  || |.:...
  Rat   127 SAPGSLSVSNVSQSP----KMA--------------QPRMEPVPSLHAKIYGAPDGPR-PAQDRL 172

  Fly   228 SNSNSSSVTNNASSGGVPASTPLGPPLSTQMPNGREKSFLGPPAPALHNGTGGRFVPPAASKRPG 292
            |..:.|...:..:.|  .:...|.|.:|: :|:.      .||....|:.      |.|.||..|
  Rat   173 SQGHCSRKCDRRAEG--DSERKLSPFISS-LPSP------VPPLSPAHSR------PQATSKAHG 222

  Fly   293 VGQ-----QPPPPEKDVNKIISDIANIFTVQ----PL-TLIAAT----------------PHAPT 331
            .|.     ....|.||         .:.|.|    || :|:|.|                |..|:
  Rat   223 SGTGTQSCYASKPSKD---------PVVTAQEKETPLDSLVAVTSLGAAPPQPPCQTFPPPPLPS 278

  Fly   332 RENYNLLAPNRQKYAMD----IPSSPPSAEP------------SSLMTPLFAPITSPIAPLVTTP 380
            :.......|......||    .||..|..:|            ..|..|..|.:|.     :..|
  Rat   279 KSIAMQQKPTAYVRPMDGQDQAPSESPELKPPLEDFGQQSFEKPDLKVPAKAKLTR-----LRMP 338

  Fly   381 PQASQMPLGGATSGTILAGEALAPL-HQLPPTM-----PKAASGVTSPGPVK------------- 426
            .|..:.|......   ...|.|..: |..|..:     |..|.....|.|.|
  Rat   339 SQTVEQPYSNEVH---CVEEILKEMTHSWPSPLTAIHTPSTAEPSRFPFPTKDPLHISSATQSQK 400

  Fly   427 ----PLKTEKNHSLEKQDSCLENDLELSESED---EQRKKE--------------------GRSG 464
                |.||..|.  ::..|.||:||:||:||:   ||..::                    ..|.
  Rat   401 QYDAPSKTHPNP--QQGTSMLEDDLQLSDSEESDVEQAVEKPPSPPAPPSAPQTIPEPVASAHSS 463

  Fly   465 GNSSNSSESD-SSESGSESSSKNDLQHHPNHQQHHHQLQQQQQQQQATMQQQQVLQQQHRSQPLT 528
            ...|.||||| ||:|.|||||.:..::.|        |:.|..:
  Rat   464 SAESESSESDSSSDSESESSSSDSEENEP--------LETQAPE--------------------- 499

  Fly   529 SNGAQNKKFRHEIIARGSNTITGLLSSSGFGSGGNVGPAGVNSNAVVGTGSGSGGTLSSGGSSSN 593

  Rat   500 ----------------------------------------------------------------- 499

  Fly   594 KTPSPTESNKWNLSRFFHKPANQTNSESVSPGNVSMKVPGILPGGAQIIPESIDVTTAIVKNEKN 658
              |.|..:|||.|..:..|    .|..||
  Rat   500 --PEPPTTNKWQLDNWLTK----VNQPSV------------------------------------ 522

  Fly   659 DMAMEEGEEEDDDEEQQLRYGGGLSVTPVAVKKEAIDAVSEMALGAIPKTQIKRESAETLLSARL 723
                                       |:..:            |:....:.::||
  Rat   523 ---------------------------PLESR------------GSTESPRCRQES--------- 539

  Fly   724 SDSGTSASGSSSSSSSSSDSAMGGEVVPMPGPGETLQLPG---VPAAITTVMRVQPTQSQKAPPS 785
              .|....||......|.|..:......:.||.|..| ||   .|.:        |.|.:..||.
  Rat   540 --KGGGEGGSDQQHPDSKDPPLKSSSKALRGPSEGPQ-PGKRNCPKS--------PAQQETPPPR 593

  Fly   786 NSVTLTPILPLPTSPKQRQKKPRKKKAITSAPILDSSDDDEPPPKHPGLDHTAVSVQTQPATDTV 850
            .:|           ..::.:||.|.......|...|..:.|..|       .|...:.|.:.|..
  Rat   594 QTV-----------GSKQPRKPTKGSTQAEQPQASSRVEGEAGP-------VAYGSKEQTSKDKP 640

  Fly   851 K-KGRGRPRKQQQSGGSGNLSSASAGSSSQTKGPTLTAA---KKPLAKTPLAMSRARKREHSSQS 911
            | |.:||||           :..|....|:...|...||   .:|.|.||:     .||:|.|.:
  Rat   641 KVKTKGRPR-----------AVGSREPKSEVPVPVPQAAVPKPQPPAPTPI-----EKRKHKSST 689

  Fly   912 SSNGNTPTKKVATPQLVAAPLKPTSNTAGSSSSDEDSSSSAESSSKSSSSSSSSDDTETQNTNCR 976
            :     |:|.::.||       ||.::||..:.:..:
  Rat   690 A-----PSKALSGPQ-------PTKDSAGDRNQEHPA---------------------------- 714

  Fly   977 IVKLNKTGAVQKKALLGSGSSSPSSSGSEAEDQTTRSQVGSGQALAQQLPPYKQLPISQHSQHLS 1041
            :|.|.:                            ::.|..||:
  Rat   715 LVSLTQ----------------------------SQGQPNSGR---------------------- 729

  Fly  1042 SSDCSSSSGGCTAVCSSSSGEEDEGRREKERERKPKSDKNKINTLTRIFNPKEGGAKKQGQVVIV 1106
                 .|.||.|:.|.                                            |.||.
  Rat   730 -----GSGGGRTSGCR--------------------------------------------QAVIT 745

  Fly  1107 DLQEEQQQGKLDAAAQPSAPQAPPAAPAAIMAKPRMTPTQQQQLGAGLASPARTTTPHLTSLICK 1171
              ||:..:.||                        :.|.:..:    |.||.|.:.|. |||:.|
  Rat   746 --QEDSCRDKL------------------------LLPLRDTK----LLSPLRDSPPP-TSLVVK 779

  Fly  1172 IDLSKLSRERIMRLKKLTPAQQNGHLTPKDQATNAVHVPNGYAGDTNPAAKVKHEHPVKPEPELD 1236
            |.|..|:|                           |..|.|..|...     |.||
  Rat   780 ITLDLLTR---------------------------VPQPPGKGGRPR-----KSEH--------- 803

  Fly  1237 AGYEAKFKPGNVKQEFQLKQERDRDRERERERERERERDREREQPPGRRRKRSSSSSSSPYKEKK 1301
                 |..|...||:.   :.|..|......::|:.|.::|......|..|..:|||||.:.|..
  Rat   804 -----KQLPAGKKQDL---EARGCDSSSRVTKKRKAEPEKEHSHKRLRLDKSQTSSSSSSHAESS 860

  Fly  1302 RKKEKADQLQMG-KELLPVPVLLPSNNHE-------RMPNHDRLSYDKLQLLHEDAAAVIGDVSA 1358
            :.|......:.. ||:||.|.::||::..       ..|.|.|...|          |.||....
  Rat   861 KSKTPRPSSECSRKEMLPPPPVVPSSSSSSSSSQKPSKPAHKRPRPD----------ADIGSQDP 915

  Fly  1359 PNGS-PTKKLLAMSPLPPPPTVTVAPA----TCNEAVQTTPPSATATSAIAPPVPATRLIYRSYF 1418
            |..| .||.....|.:|....|....:    :..:|....|..:.......|..|..:
  Rat   916 PRSSGSTKSSCTDSSVPKHRKVQARDSEHKGSSGDAANPFPVPSLPNGNSKPGKPQVK------- 973

  Fly  1419 DRDVEHPSDDPRKNNQFLQEAINRKHAADLERDSFNQVTLYLEAVVYFLLTADAMERCSSEQATN 1483
                    .|.::.:..::||...|..|:...|...:...|||||:.|:....|.|..||.::..
  Rat   974 --------SDRQQADFHMKEAKKLKCKAEAMVDKAGKAFKYLEAVLSFIECGMATESESSAKSAY 1030

  Fly  1484 TMYKDTLSLIKFI------STKFRPYQQQSTTNIQHETHNKVAILSLRCQSLISLKLYKLRRKDC 1542
            |:|.:|:.||||:      |....|.|::.           .|:|.||||||:::.:::.::...
  Rat  1031 TVYSETVDLIKFVMSLKSFSDNTVPAQEKI-----------FAVLCLRCQSLLNMAMFRCKKDTV 1084

  Fly  1543 RAIINSLTDFFR------------VGRGDIANGNTPSSISPSNSVGSQGSGSNTPPGRIV----- 1590
            .....:|::.||            |.|    :...||.:||..|..| .:||.|..|..:
  Rat  1085 MKYSRTLSEHFRSTSKVAQAPSPCVAR----STGVPSPVSPMPSPAS-SAGSQTSAGSSMGAMGA 1144

  Fly  1591 ------PPDIHNMLCKQNEFLSYLNSAHELWDQADRLVRTGNHIDFIRELDHENGPLTLHSTMHE 1649
                  |..|.||........|::..|..||:||:.|.|...  :|..:|..:...|.|:|::.:
  Rat  1145 TATVSTPVTIQNMTSSYVTITSHVLKAFTLWEQAEALTRKNK--EFFAQLSTKVRVLALNSSLVD 1207

  Fly  1650 VFRYVQAGLKTLRDAVSHP 1668
            :..|.:.||:.||.|...|
  Rat  1208 LVHYTRQGLQRLRQAPQTP 1226

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lilli	NP_001137775.1	AF-4	<1435..1662	CDD:282905	68/255 (27%)
Aff1	XP_038947749.1	AF-4	17..515	CDD:398672	132/665 (20%)
		PRK03427	<519..>643	CDD:235124	34/236 (14%)
		PRK14971	<588..720	CDD:237874	42/205 (20%)
		AF4_int	776..790	CDD:408645	7/40 (18%)
		AF-4_C	965..1226	CDD:408646	74/293 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341543
Domainoid	1	1.000	132	1.000	Domainoid score	I4970
eggNOG	1	0.900	-	-		E1_28IRS
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I4034
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001371
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10528
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.980