DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lilli and Aff4

DIOPT Version :9

Sequence 1:	NP_001137775.1	Gene:	lilli / 33496	FlyBaseID:	FBgn0041111	Length:	1673	Species:	Drosophila melanogaster
Sequence 2:	XP_006246325.1	Gene:	Aff4 / 303132	RGDID:	1311694	Length:	1159	Species:	Rattus norvegicus

Alignment Length:	1694	Identity:	338/1694 - (19%)
Similarity:	533/1694 - (31%)	Gaps:	647/1694 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 RRKRREREKIERQQGIQIDDRETSLFGEPRRLTEGD----AEITAALGEFFEAREYINNQT---- 121
            |.|.|||...|.|||.......:.||.||.::|..:    :.|.:.||.:.|.::||.:::
  Rat    10 RMKERERRNQEIQQGEDAFPPSSPLFAEPYKVTSKEDKLSSRIQSMLGNYDEMKDYIGDRSIPKL 74

  Fly   122 VGISRSA-PGAGNPRLQPNLAPQAKSLGHSPSSASSAAGPTAASATTSLPGQQQHYQQQQRPPTY 185
            |.|.:.| |...:.:..||...|.    |..|..||...|...:.:||        |.|:|....
  Rat    75 VAIPKPAVPTTTDEKANPNFFEQR----HGGSHQSSKWTPVGPAPSTS--------QSQKRSSGL 127

  Fly   186 VKQADNKPPYNGRGGYPGQPMKNDIPS------------------SSGMAPPRGPPRTSSSNSNS 232
            .....::....|..|..|...::|..|                  ||....|:.....|||:|.|
  Rat   128 QSGHSSQRSSAGGSGASGSGQRHDRDSYSSSRKKGQHGSEHSKSRSSSPGKPQAVSSLSSSHSRS 192

  Fly   233 SSVTNNASSGGVPASTPLGPPLSTQMP------NGREKSFLGPPAPALHNGTGGRFVPPAASKRP 291
            .. .::.|.....:.:|..|..:...|      :|:..|...|  |:|.:.:......|.|..||
  Rat   193 HG-NDHHSKEHQRSKSPRDPDANWDSPSRVPFSSGQHSSQSFP--PSLMSKSSSMLQKPTAYVRP 254

  Fly   292 GVGQQPPPPEKDVNKIISDIANIFTVQPLTLIAATPHAPTRENYNLLAPNRQKYAMDIPSSPPSA 356
            ..||:...|     |:.|                       |:|     :.|.:..::....||:
  Rat   255 MDGQESVEP-----KLSS-----------------------EHY-----SSQSHGSNMTELKPSS 286

  Fly   357 EPSSLMTPLFAPITSPIAPLVTTPPQASQMPLGGATSGTI-LAGEALAPL-HQLPPTM-----PK 414
            :  :.:|.|..|                ..||..:.||.: ...|.|..: |..||.:     |.
  Rat   287 K--AHLTKLKIP----------------SRPLDASVSGDVSCVDEILKEMTHSWPPPLTAIHTPC 333

  Fly   415 AASGVTSPGPVK-----------------PLKTEKNHSLEKQDSCLENDLELSESEDEQRKKEGR 462
            .......|.|.|                 ..||...|   :..|.|::||:||.|||
  Rat   334 KTEPSKFPFPTKESQQSNFGSGEQKRYSTSAKTSNGH---QSKSMLKDDLKLSSSED-------- 387

  Fly   463 SGGNSSNSSESDSSESGSESSSKNDLQHHPNHQQHHHQLQQQQQQQQATMQQQQVLQQQHRSQPL 527
                |....:.|.:...|...|.::..||
  Rat   388 ----SDGEQDCDKTMPRSTPGSNSEPSHH------------------------------------ 412

  Fly   528 TSNGAQNKKFRHEIIARGSNTITGLLSSSGFGSGGNVGPAGVNSNAVVGTGSGSGGTLSSGGSSS 592
            .|.||.|.:       ..|::.:|..||||..|...              .|.|....:....|:
  Rat   413 NSEGADNSR-------DDSSSHSGSESSSGSDSESE--------------SSSSDSEANEPSQSA 456

  Fly   593 NKTPSPTESNKWNLSRFFHKPANQTNSESVSPGNVSMKVPGILPGGAQIIPESIDVTTAIVKNEK 657
            :..|.|..:|||.|..:.    |:.|...|||.:                  |:|
  Rat   457 SPEPEPPPTNKWQLDNWL----NKVNPHKVSPAS------------------SVD---------- 489

  Fly   658 NDMAMEEGEEEDDDEEQQLRYGGGLSVTPVAVKKEAIDAVSEMALGAIPKTQ-IKRESAETLLSA 721
                                                         ..||.:| .|:|..|...::
  Rat   490 ---------------------------------------------SNIPSSQAYKKEGREQGTAS 509

  Fly   722 RLSDSGTSASGSSSSSSSSSDSAMGGEVVPMPGPGETLQLPGVPAAITTVMRVQPTQSQKAPPSN 786
            ..:|.|.:...||::....|.:...|.
  Rat   510 NYTDPGGAKEASSATPGRDSKTIQKGS-------------------------------------- 536

  Fly   787 SVTLTPILPLPTSPKQRQKKPRKKKAITSAPILDSSDDDEPPPKHPGLDHTAVSVQTQPATDTVK 851
                       .|.:.|||.|                                 .|:...|....
  Rat   537 -----------ESGRGRQKSP---------------------------------AQSDSTTQRRT 557

  Fly   852 KGRGRPRKQQQSGGSGNLSSASAGSSSQTKGPTLTAAKKPL------AKTPLAMSRARKREHSSQ 910
            .|:.:|:|.::|                       ||::|.      ::||:.|:       :|.
  Rat   558 VGKKQPKKTEKS-----------------------AAEEPRGGLKIESETPVDMA-------TSM 592

  Fly   911 SSSNGNTPTKKVATPQLVAAPLKPTSNTAGSSSSDEDSSSSAESSSKSSSSSSSSDDTETQNTNC 975
            .||.....||....|.:          ...|.||...::...:..|.|.||..|.:..||
  Rat   593 PSSRHKAATKGSRKPNI----------KKESKSSPRPTAEKKKYKSASKSSQKSREIIET----- 642

  Fly   976 RIVKLNKTGAVQKKALLGSGSSSPSSSGSEAEDQTTRSQVGSGQALAQQLPPYKQLPISQHSQHL 1040
                                    .||.|:::::             :.|||..|.|....|..
  Rat   643 ------------------------DSSSSDSDER-------------ESLPPSSQTPKYPESNR- 669

  Fly  1041 SSSDCSSSSGGCTAVCSSSSGEEDEGRREKERERKPKSDKNKINTLTRIFNPKEGGAKKQGQVVI 1105
                        |.|..||:.|:|...|:                  |:|:|.|
  Rat   670 ------------TPVKPSSAEEDDSFFRQ------------------RMFSPME----------- 693

  Fly  1106 VDLQEEQQQGKLDAAAQPSAPQAPPAAPAAIMAKPRMTPTQQQQLGAGLASPARTTTPHLTSLIC 1170
                                                     :::|.:.|:.|     .....||.
  Rat   694 -----------------------------------------EKELLSPLSDP-----DDRYPLIV 712

  Fly  1171 KIDLSKLSRERIMRLKKLTPAQQNGHLTPKDQATNAVHVPNGYAGDTNPAAKVKHEHPVKPEPEL 1235
            ||||:.|:|......|:..|        ||.:..|   ||.            ||...|:.:...
  Rat   713 KIDLNLLTRIPGKPYKETEP--------PKGEKKN---VPE------------KHSREVQKQASE 754

  Fly  1236 DAGYEAKFKPGNVKQEFQLKQERDRDRERERERERERERDREREQPPGRRRKRSSSSSSSPYKEK 1300
            .|..:.|            ::.::.|..|..|.::.:..|:             :||:..|...|
  Rat   755 KASNKGK------------RKHKNDDDNRASESKKPKTEDK-------------NSSAHKPSSSK 794

  Fly  1301 KRKKEKADQLQMGKELLPVPV-LLPSNNHERMPNHDRLSYDKLQLLHEDAAAVIGDVSAPNGSPT 1364
            :..|:.:.:   .|:|||.|. .:||.:.:......:.:..:...|...:.:     :..|...:
  Rat   795 ESSKQSSTK---EKDLLPSPAGPVPSKDSKTEHGSRKRTVSQSSSLKSSSTS-----NKENSGSS 851

  Fly  1365 KKLLAMSPLPPPPTVTVAPATCNEAVQTTP------PSATATSAIAPPVPATRLIY--RSYFDRD 1421
            |.  ..|......|.....::..||.:..|      |.:|.|...:.| ..|:|.:  |:|   .
  Rat   852 KS--TSSTAKQKKTEGKVSSSSKEAKEKAPNSSSNCPPSTPTPDSSKP-RRTKLAFDDRNY---S 910

  Fly  1422 VEHPSDDPRKNNQFLQEAINRKHAADLERDSFNQVTLYLEAVVYFLLTADAMERCSSE-QATNTM 1485
            .:|          :||||...||.||...|.|.:...||:|||.|:...:|:|:.:.| ::...|
  Rat   911 ADH----------YLQEAKKLKHNADALSDRFEKAVYYLDAVVSFIECGNALEKNAQESKSPFPM 965

  Fly  1486 YKDTLSLIKFISTKFRPYQQQSTTNIQHETHNKVAILSLRCQSLISLKLYKLRRKDCRAIINSLT 1550
            |.||:.|||: :.|.:.|.....|    ....::.:|.||||||:.|:|:||::::......:||
  Rat   966 YSDTVELIKY-TMKLKNYLAPDAT----AADKRLTVLCLRCQSLLYLRLFKLKKENALKYSKTLT 1025

  Fly  1551 DFFR----------VGRGDIANGNTPSSISPSNSVGSQG-----------SGSNTPPGRIVPPDI 1594
            :..:          .|.|..|.| .||.:||..|.|:.|           |||:.    .:|..|
  Rat  1026 EHLKNSYSNSQAPSPGLGSKAVG-MPSPVSPKLSPGNSGSYSSGGSSASASGSSV----TIPQKI 1085

  Fly  1595 HNMLCKQNEFLSYLNSAHELWDQADRLVRTGNHIDFIRELDHENGPLTLH-STMHEVFRYVQAGL 1658
            |.|.....:..|....|.|:||||::|.:  ...:|..|||...|||..: |.|.::.||.:.||
  Rat  1086 HQMAASYVQVTSNFLYATEIWDQAEQLSK--EQKEFFAELDKVMGPLIFNASIMTDLARYTRQGL 1148

  Fly  1659 KTLR 1662
            ..||
  Rat  1149 HWLR 1152

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lilli	NP_001137775.1	AF-4	<1435..1662	CDD:282905	81/249 (33%)
Aff4	XP_006246325.1	AF-4	3..1155	CDD:282905	338/1694 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341542
Domainoid	1	1.000	132	1.000	Domainoid score	I4970
eggNOG	1	0.900	-	-		E1_28IRS
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I4034
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001371
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10528
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.980