Protein Alignment lilli and Aff2

DIOPT Version :10

• Sequence 1: NP_523464.1
• Gene: lilli / 33496
• FlyBaseID: FBgn0041111
• Length: 1673
• Species: Drosophila melanogaster
• Sequence 2: XP_006527879.1
• Gene: Aff2 / 14266
• MGIID: 1202294
• Length: 1308
• Species: Mus musculus
• Alignment Length: 1765
• Identity: 351/1765 - (19%)
• Similarity: 549/1765 - (31%)
• Gaps: 662/1765 - (37%)

  Fly    54 YSQNYNMEEYERRKRR-EREKIERQQGIQIDDRETSLFGEPRRLTE----GDA---EITAALGEF 110
            ::.:|..:....:||. ||...|.||...:......|||||.::.|    |||   .:...||.:
Mouse    44 FASHYEQDRSALKKREWERRNQEVQQEEDLFSSGFDLFGEPYKVAEYTNKGDALANRVQNTLGSY 108

  Fly   111 FEAREYINNQT-----VGISRSAPGAGNPRLQPNLAPQAKSLGHSPSSASSAAGPTAASATTSLP 170
            .|.::.::|.:     |||.:            |.|||.               |.:.|..:..|
Mouse   109 DEMKDLLSNHSSQNHLVGIPK------------NSAPQT---------------PISKSEASFYP 146

  Fly   171 GQQQHYQQQQRPPTYVKQADNKPPYNGRGGYPGQPMKNDIPSSSGMAPPRGPPRTSS---SNSNS 232
            .|:.......:..|:                          ||:.|.||......|:   ||..|
Mouse   147 EQKNRMIPSHQETTH--------------------------SSTPMPPPSVVILNSTLIHSNRKS 185

  Fly   233 SSVTNNASSGGVPASTPLGPPLSTQMPNGREKSFLGPPAPALHNGTGGRFVPPAASKRPGVGQQP 297
            .|.....|....||..    ..::..||..:.|...||...|.:    .||.||...:.|..::.
Mouse   186 KSEWPRDSHNTSPAQA----SQTSSQPNKMQTSTQDPPQTRLED----FFVYPAEQPQIGTVEKS 242

  Fly   298 PPPEKDVNKIISDIANIFTVQPLTLIAATPHAPTRENYNLLAPNRQKYAMDIPSSPPSAE----P 358
            .|..|:.|...|...:.|                :|.:...:|...::.:..|.||..|.    |
Mouse   243 NPSSKEENNPNSGGEDTF----------------KEIFQSNSPEESEFTVQAPGSPLVASSLLAP 291

  Fly   359 SS-LMTPLFAP------------ITSPIAPL-----------VTTPPQASQMPLGGATSGTILAG 399
            || |..|.|.|            .|:.:.|:           ...|....:...|..:.|::|.|
Mouse   292 SSGLSVPTFPPGLYCKTSMGQQKPTAYVRPMDGQDQATDISPTLKPSIEFENSFGNLSFGSLLDG 356

  Fly   400 EALAPLHQLPPTMPKAASGVTSPGPVKPLKTEKNHSLEKQDSCLENDLELSESEDEQRKKEGRSG 464
            :            |.|.|..|.......|:|.: .||....||:|..|..|:........:..|.
Mouse   357 K------------PSAVSSKTKLPKFTILQTSE-VSLTSDPSCVEEILRESQHLTPGFTLQKWSD 408

  Fly   465 GNSSNSSESDSSESGSE-----SSSKNDLQHHPNHQQHHHQLQQQQQQQQATMQQQQVLQQQHRS 524
            .:|..|::|...:|..|     ||.::||:          .::....|..|....|.|.:.:.::
Mouse   409 PSSRASTKSVPLKSMLEDDLKLSSDEDDLE----------PVKTLTTQCTANELYQAVEKAKPKN 463

  Fly   525 QPLTSNGAQNKKFRHEIIARGSNTITGLLSSSGFGSGGNVGPAGVNSNAVVGTGSGSGGTLSSGG 589
            .|:           :.::|...:|.         .:..||| :|.:|.:...:.|.|....|:..
Mouse   464 NPV-----------NPLLATPQSTP---------ATQTNVG-SGSSSESESSSESDSDTESSTTD 507

  Fly   590 SSSNKT-------PSPTESNKWNLSRFFHKPANQTNS----ESVSP-GNVSMKVPGILPGGAQII 642
            |.||:.       |.|..:|||.|.::.:|..:|..|    ::.:| ..:|:..|.|.|
Mouse   508 SESNEAPRVATPEPEPPSTNKWQLDKWLNKVTSQNKSFICGQNETPTETISLPPPIIQP------ 566

  Fly   643 PESIDVTTAIVKNEKNDMAMEEGEEEDDDEEQQLRYGGGLSVTPVAVKKEAIDAVSEMALGAIPK 707
               ::|...:..|...                           .|||.||.            |.
Mouse   567 ---VEVQVKVKPNPSQ---------------------------AVAVPKER------------PL 589

  Fly   708 TQIKRESAETLLSARLSDSGTSASGSSSSSSSSSDSAMGGEVVPMPGPGETLQLPGVPAAITTVM 772
            ..:.||.|....:.:..::.......|:|..:.|...:|
Mouse   590 LSLIREKARPRPTQKTPETKALKHKLSTSVDTVSQRTIG-------------------------- 628

  Fly   773 RVQPTQSQKA--------PPSNSVTLTP----ILPLPTSPKQRQKKPRKKKAITSAPILDSSDDD 825
            :.||.:.:|.        |..|....||    .:.||..|:.|.|....|
Mouse   629 KKQPKKVEKNTSFEEFTWPKPNITNSTPKEKGSVELPDPPRSRNKATAHK--------------- 678

  Fly   826 EPPPKHPGLDHTAVSVQTQPATDTVKKGRGRPRKQQQSGGSGNLSSASAGSSSQTKGPTLTAAKK 890
             |.|:                                                          |:
Mouse   679 -PVPR----------------------------------------------------------KE 684

  Fly   891 PLAKTPLAMSRARKREHSSQSSSNGNTPTKKVATPQLVAAPLKPTSNTAGSSSSDEDSSSSAESS 955
            |....|||                  |..||...|..:.                   ..|.|..
Mouse   685 PRPHVPLA------------------TEKKKYRGPGKIV-------------------PKSREFI 712

  Fly   956 SKSSSSSSSSDDTETQNTNCRIVKLNKTGAVQKKALLGSGSSSPSSSGSEAEDQTTRSQVGSGQA 1020
            ...||:|.|:.|                                       :::|.:.:|
Mouse   713 ETDSSTSDSNTD---------------------------------------QEETLQIKV----- 733

  Fly  1021 LAQQLPPYKQLPISQHSQHLSSSDCSSSSGGCTAVCSSSSGEEDEGRREKERERKPKSDKNKINT 1085
                |||                            |.:|               |.|...|...|
Mouse   734 ----LPP----------------------------CITS---------------KSKETSNASLT 751

  Fly  1086 LTRIFNPKEGGAKKQGQVVIVDLQEEQQQGKLDAAAQPSAPQAPPAAPAAIMAKPRMTPTQQQQL 1150
            |:.:.|                    .....|..:.:.:|...|||                  :
Mouse   752 LSTLTN--------------------GNSNNLSTSNEETAFSPPPA------------------M 778

  Fly  1151 GAGLASPART-TTPHLTSLICKIDLSKLSRERIMRLKKLTPAQQNGHLT---PKDQ-ATNAVHVP 1210
            ...|.||.|. ..|  .:|..||||..|||........:|||:.:...|   ||.| |..||.
Mouse   779 QTELLSPLRDHENP--KNLWVKIDLDLLSRVPGQNSVPVTPAKTDYKETASKPKRQTAATAVE-- 839

  Fly  1211 NGYAGDTNPAAKVKHEHPVKPEPELDAGYEAKFKPGNVKQEFQLKQERDRDR------------- 1262
                   .||.|.|.:|                ||....::...|::|..|.
Mouse   840 -------KPAPKGKRKH----------------KPAETAEKIPEKKQRLEDNTTICLLPPCISPA 881

  Fly  1263 -------ERERERERERERDRER----------EQPPGRRRKRSSSSSSSPYKEKKRKKEKADQL 1310
                   .||....|...:..|:          |.||   |:|:.|.::..:.:.| ....|.|:
Mouse   882 PPHKPPSTRENSSRRANRKKEEKLFPPALSPLAEDPP---RRRNVSGNNGHFGQDK-NISMAGQI 942

  Fly  1311 QMGKELLPVPVLLPSNNHERMPNHDRLSYDKLQLLHEDAAAVIGDVSAPNGSPTKK--------- 1366
            ...|         |..:..:.                  .|....:|...|...||
Mouse   943 TSSK---------PKRSEGKF------------------CATFKGISINEGDAPKKAASATVTVA 980

  Fly  1367 ------LLAMSPLPPPPTVTVAPATCNEAVQTTPPSATATSAIAPPVPATRLIYRSYFD------ 1419
                  ..|.:.:|...|.||.......|..||..:.|..|:|.|.: .:.|:..|:.:
Mouse   981 NMALATATATATVPAIVTATVTATATTTATATTTTTTTTISSITPTI-TSGLMDSSHLEMTSWAA 1044

  Fly  1420 --------RDVEHPS---DDPRKNNQF-LQEAINRKHAADLERDSFNQVTLYLEAVVYFLLTADA 1472
                    .:|..|.   ||...|..| :|||...||.||...:.|.:...|.:|.:.|....:|
Mouse  1045 LPLLSSSSANVRRPKLTFDDSVHNADFYMQEAKKLKHKADALFEKFGKAVNYADAALSFTECGNA 1109

  Fly  1473 MERCSSE-QATNTMYKDTLSLIKFISTKFRPYQQQSTTNIQHETHNKVAILSLRCQSLISLKLYK 1536
            |||...| ::..|||.:|:.|::: :.:.:.:    .:.:..:...|:|:|..||.||:.|:::|
Mouse  1110 MERDPLEAKSPYTMYSETVELLRY-AMRLKNF----ASPLASDGDKKLAVLCYRCLSLLYLRMFK 1169

  Fly  1537 LRRKDCRAIINSLTDFFRVGRGD--------IANG-NTPS-----SISPSNSVGSQGSGSNTPPG 1587
            |::........||.::|:.....        :.|| ||||     ::||.||||:..:|..|
Mouse  1170 LKKDHAMKYSRSLMEYFKQNASKVTQIPSPWVGNGKNTPSPVSLNNVSPINSVGNCNNGPVT--- 1231

  Fly  1588 RIVPPDIHNMLCKQNEFLSYLNSAHELWDQADRLVRTGNHIDFIRELDHENGPLTLHSTMHEVFR 1652
              :|..||:|........|.:...:|.||.||:|.|  ::.:|..:||...||||.||:|..:.|
Mouse  1232 --IPQRIHHMAASHVNITSNVLRGYEHWDMADKLTR--DNKEFFGDLDTLMGPLTQHSSMTNLVR 1292

  Fly  1653 YVQAGLKTLR 1662
            ||:.||..||
Mouse  1293 YVRQGLCWLR 1302

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lilli	NP_523464.1	AF-4_C	1435..1662	CDD:465894	76/242 (31%)
Aff2	XP_006527879.1	AF-4	48..536	CDD:461550	129/608 (21%)
		DUF5401	551..>693	CDD:375164	40/307 (13%)
		PTZ00449	<568..866	CDD:185628	96/629 (15%)
		AF4_int	795..809	CDD:436798	8/13 (62%)
		AF-4_C	1053..1308	CDD:465894	83/262 (32%)