Protein Alignment lilli and aff2

DIOPT Version :10

• Sequence 1: NP_523464.1
• Gene: lilli / 33496
• FlyBaseID: FBgn0041111
• Length: 1673
• Species: Drosophila melanogaster
• Sequence 2: XP_002934593.2
• Gene: aff2 / 100487096
• XenbaseID: XB-GENE-952102
• Length: 1256
• Species: Xenopus tropicalis
• Alignment Length: 1751
• Identity: 356/1751 - (20%)
• Similarity: 581/1751 - (33%)
• Gaps: 648/1751 - (37%)

  Fly    54 YSQNYNMEE---YE------RRKRREREKIERQQGIQIDDRETSLFGEPRRLTEGDA---EITAA 106
            :.:::::::   ||      :||..||...|.||...:.....:|||||.:..:|||   .:...
 Frog     6 FFRDWDLDQQCHYEQDRSALKRKEWERRTQEVQQDEDLFASGFNLFGEPYKTNKGDALANRVQNT 70

  Fly   107 LGEFFEAREYI---NNQT--VGISRS------APGAGN-----PRLQPNLAPQAKSLGHSPSSAS 155
            ||.:.|.::.:   |||:  |||.::      ||...|     |..:..|||..:|..| ||  |
 Frog    71 LGNYDEMKDLLTNHNNQSHLVGIPKNSVPQTPAPVEKNEQSFFPDQRNRLAPCHQSSSH-PS--S 132

  Fly   156 SAAGPTAASATTSLPGQQQHYQQQQRPP-------------TYVKQADNKPP------------- 194
            |...|::.:..|:|    .|..:..|..             |...|..|:|.
 Frog   133 SMPPPSSLAPNTTL----THNHEGSRKSRVDWAHGGHTSSCTQSNQLSNQPSRLKHTSSHDLLQI 193

  Fly   195 -----YNGRGG-YPGQPMKNDIPSSSGMAPPR-GPPRTSS------SNSNSSSVTNNASSGGVPA 246
                 ||.:.. |....:...||::|.....| ..|:..|      .|::|.|..::.:.|....
 Frog   194 RYEDLYNCQNDQYKSGVIDELIPATSSSHSRRHNHPKALSGEHVFKENAHSKSPVDSETLGHGSV 258

  Fly   247 STPLGPPLSTQMPNGREKSFLGPPAPALHNGTGGRFVPPAASKRPGVGQQPPP---PEKDVNKII 308
            | || |..|....|....|...|  |.:|:.|......|.|..||..||...|   ||...:..|
 Frog   259 S-PL-PSTSLLAANNSLSSQNFP--PGIHSKTSMVQQKPTAYVRPMDGQDQVPNDSPELKPSTEI 319

  Fly   309 SDIANIFTVQPL--TLIAATPHAPTRENY--NLLAPNRQKYAMDIPSSPPSAEPSSLMTPLFAPI 369
            .|..|    .||  ||:....:.|..::.  .|..|  |...:.:|:.|...|      .:...:
 Frog   320 DDGYN----NPLFGTLLEGKVNVPVTKSKLPKLTIP--QGNEVSLPNDPNCVE------EILREM 372

  Fly   370 TSPIAPLVT---TPPQASQMPLGGATSGTILAGEALAPLHQLPPTMPKAASGVTSPGPVKPLKTE 431
            |....|.:|   ||.:|.|...                     |...|.:..:||...|:.....
 Frog   373 THSWPPPLTAIHTPCKAEQTKF---------------------PIPSKESQHLTSGYNVQKRCDA 416

  Fly   432 KNHSLEK---QDSCLENDLELSESEDEQRKKEGRS----------------GGNSSNSSESDSSE 477
            .|.:..|   |.|.||:||:||..|::..:...::                |.|..|||....|.
 Frog   417 TNKTTAKSAPQKSMLEDDLKLSSDEEDSEQANEKTKPRNIPVNGLPLQAVHGANLVNSSGGSGSS 481

  Fly   478 SGSESSSKNDLQHHPNHQQHHHQLQQQQQQQQATMQQQQVLQQQHRSQPLTSNGAQNKKFRHEII 542
            |.|||||::|..                                  |:..:|:...|::.|
 Frog   482 SESESSSESDSD----------------------------------SESSSSDSECNEQAR---- 508

  Fly   543 ARGSNTITGLLSSSGFGSGGNVGPAGVNSNAVVGTGSGSGGTLSSGGSSSNKTPSPTESNKWNLS 607
                                                            |:...|.|..:|||.|.
 Frog   509 ------------------------------------------------SATPEPEPPSTNKWQLD 525

  Fly   608 RFFHKPANQTNSESVSPGNVSMKVPGILPGGAQIIPESIDVTTAIVKNEKNDMAMEEGEEEDDDE 672
            ::.:|         |:|.|.:            ||....||      :.:|:...:..::.:..|
 Frog   526 KWLNK---------VNPHNKT------------IISSQNDV------HSENNSETQNNQQAEGKE 563

  Fly   673 EQQLRYGGGLSVTPVAVKKEAIDAVSEMALGAIPKTQIKRESAETLLSARLSDSGTSASGSSSSS 737
            :.:|.     ::|.....||.:..|.|
 Frog   564 KTELD-----NITSQPDSKELLSPVRE-------------------------------------- 585

  Fly   738 SSSSDSAMGGEVVPMPGPGETLQLPGVPAAITTVMRVQPTQSQKAPPSNSVTLTPILPLPTSPKQ 802
                                               :.:|..:||.|.|
 Frog   586 -----------------------------------KSKPRATQKNPDS----------------- 598

  Fly   803 RQKKPRKKKAITSAPILDSSDDDEPPPKHPGLDHTAVSVQTQPATDTVKKGRGRPRKQQQSGGSG 867
               ||.|:|:              |.|..|         .||.|  |.||   :|:|.:::
 Frog   599 ---KPLKQKS--------------PAPNEP---------ITQRA--TAKK---QPKKVERT---- 628

  Fly   868 NLSSASAGSSSQTKGPTLTAAKKPLAKTPLAMSRARKREHSSQSSSNGNTPTKKVATP---QLVA 929
                                                    ||...:..|.|....:||   ::..
 Frog   629 ----------------------------------------SSVEENTWNKPNPTCSTPKEKEVRE 653

  Fly   930 APLKPTSNTAGSSSSDEDSSSSAESSSKSSSSSSSSDDTETQNTNCRIVKLNKTGAVQKKALLGS 994
            .|.:|.:.|..:      .:.:|....:.:|:.|||:..:|:.|:..:.|        .:..:.:
 Frog   654 TPEQPKTRTKTT------VAKTAPRKEQRTSTGSSSEKKKTRGTSKNVPK--------SREFVET 704

  Fly   995 GSSSPSSSGSEAEDQTTRSQVGSGQALAQQLPPYKQLPISQHSQHLSSSDCSSSSGGCTAVCSSS 1059
            .|:|.|::..|...|...|...||       ||          ..:.|.|||.:....:::.|:|
 Frog   705 DSASDSNTDQEEVLQVKISTACSG-------PP----------NPIKSKDCSGNILSVSSLTSNS 752

  Fly  1060 SG-EEDEGRREKERERKPKSDKNKINTLTRIFNPKEGGAKKQGQVVIVDLQEEQQQGKLDAAAQP 1123
            |. ..|:...:.|.               ..|:|
 Frog   753 SSISVDQTNNDLEE---------------HFFSP------------------------------- 771

  Fly  1124 SAPQAPPAAPAAIMAKPRMTPTQQQQLGAGLASPARTTTPHLTSLICKIDLSKLSRERIMRLKKL 1188
                               .|..|.:    |.||.| ....:.||..||||:.|||
 Frog   772 -------------------LPVVQTE----LLSPLR-DFEEVKSLWVKIDLTLLSR--------- 803

  Fly  1189 TPAQQNGHLTPKDQATNAVHVPNGYAGDTNPAAKVKHEHPVKPEPELDAGYEAKFKPGNVKQEFQ 1253
            .|.|:...:.|......    .:|:          ||:|.:         .....:..:.|...:
 Frog   804 IPGQETFDVLPLKSDPR----ESGF----------KHKHQI---------MNTAVEKSSTKSRRK 845

  Fly  1254 LKQERDRDRERERERERERERDREREQPPGRRRKRSSSSSSSPYKEKKRKKEKADQLQMGKELLP 1318
            .||....|.:.:.:|:|..:.......||......|:..:|:  ||.||..:|.::     ::.|
 Frog   846 HKQTESSDTQSDNKRQRLEDNTPPCLLPPCISPIPSTRITST--KETKRTTKKREE-----KVFP 903

  Fly  1319 VPVLLPSNNHERMPNHDRLSYDKLQLLHEDAAAVIGDVSAPNGSPTKKLLAMSPLPPPPTVT--- 1380
             |:|.|..:......|                      |:.|||.:::....:.:....|.|
 Frog   904 -PLLSPLGDEPICRRH----------------------SSDNGSFSQESNVTTSMHTASTNTRHR 945

  Fly  1381 -------VAPATCNEAVQTTPPSATATSAI-----APPVPAT-------RLIYRS---YFDRDVE 1423
                   .|..:|.|  ..:.|::.....|     .|.:.:|       .:.||.   .|| |..
 Frog   946 KNSNMAANAKISCEE--DHSRPASCVIENIDHDHSEPDIWSTETTLTNGNIDYRRSKITFD-DTL 1007

  Fly  1424 HPSDDPRKNNQFLQEAINRKHAADLERDSFNQVTLYLEAVVYFLLTADAMERCSSE-QATNTMYK 1487
            |.:|      .::|||...||.||...:.|.:...|.:|.:.|:...:||||...| ::..|||.
 Frog  1008 HNAD------YYMQEAKRLKHKADALMEKFGKAVNYADAALSFIECGNAMERDPLEAKSPYTMYS 1066

  Fly  1488 DTLSLIKFISTKFRPYQQQSTTNIQHETHNKVAILSLRCQSLISLKLYKLRRKDCRAIINSLTDF 1552
            :|:.||:: :.:.:.:...:.|    |...|:.:|..||.||:.|:::||::........||.::
 Frog  1067 ETVELIRY-AMRLKNFTGSAAT----EGEKKLVVLCYRCLSLLYLRMFKLKKDHAMKYSRSLMEY 1126

  Fly  1553 FRVGR----------GDIANGNTPS--SISPS--NSVG-SQGSGSNTPPGRI-VPPDIHNMLCKQ 1601
            |:...          |:..|..|||  |:|||  |:.| |.|:|:::..|.: :|..||:|....
 Frog  1127 FKNSSKSSQAPSPWGGNGKNTETPSPMSLSPSPVNTAGNSTGTGASSSTGTVSIPQRIHHMAASH 1191

  Fly  1602 NEFLSYLNSAHELWDQADRLVRTGNHIDFIRELDHENGPLTLHSTMHEVFRYVQAGLKTLR 1662
            ....:.:..::|.||.||:|  |..:.:|.::||....|||.||:|..:.|||:.||..||
 Frog  1192 VNITNNVLRSYEHWDMADKL--TKENKEFFQDLDTVMEPLTQHSSMTYLVRYVRQGLHWLR 1250

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lilli	NP_523464.1	AF-4_C	1435..1662	CDD:465894	76/243 (31%)
aff2	XP_002934593.2	AF-4	18..529	CDD:461550	142/640 (22%)
		AF4_int	792..806	CDD:436798	8/22 (36%)
		AF-4_C	997..1256	CDD:465894	84/268 (31%)