Protein Alignment lilli and aff4

DIOPT Version :10

• Sequence 1: NP_523464.1
• Gene: lilli / 33496
• FlyBaseID: FBgn0041111
• Length: 1673
• Species: Drosophila melanogaster
• Sequence 2: XP_002935317.3
• Gene: aff4 / 100485382
• XenbaseID: XB-GENE-986475
• Length: 1148
• Species: Xenopus tropicalis
• Alignment Length: 1681
• Identity: 342/1681 - (20%)
• Similarity: 531/1681 - (31%)
• Gaps: 618/1681 - (36%)

  Fly    59 NMEEYE--RRKRREREKIERQQGIQIDDRETSLFGEPRRLTEGDAE----ITAALGEFFEAREYI 117
            |.||..  |.|.|||...|.|||.:....::.||.||.::|..:.:    |.:.||.:.|..|.
 Frog     2 NREERNLLRLKERERRNQEIQQGEEAFPSDSPLFAEPYKVTSKEDKLSNRIQSMLGNYDEMNEM- 65

  Fly   118 NNQTVGISRSAPG-AGNPR-LQPNLAPQAKS----LG---HSPSSASSAAGPTAASATTSLPGQQ 173
             |:.: ..||.|. ||.|: ..|..||..|:    .|   |..|..||...|...:.:||...|:
 Frog    66 -NEMI-TDRSLPKLAGIPKSAVPPTAPDDKTGQGYFGDQRHGSSHQSSKWTPVGPAPSTSSQSQK 128

  Fly   174 QHYQQQQRPPTYVKQADNKPPYNGRGGYPGQPMKNDIPSSSGMAPPRGPPRTSSSNSNSSSVTNN 238
            :.....|...:....:::....:.|..|.....|....|....:....|.:.|:.||:.|....|
 Frog   129 RSSSSSQGGHSRSSGSNSSSQRHDRDSYSSSRKKGQHSSEHSKSRSISPGKQSALNSSHSRAHGN 193

  Fly   239 --ASSGGVPASTPLGPPLSTQMP-------NGREKSFLGPPAPALHNGTGGRFVPPAASKRPGVG 294
              .|.....|.:|..|..:...|       :|:..|...|  |:|.:.:......|.|..||..|
 Frog   194 DHHSKERPHAKSPRDPDANWDSPSRAPSFSSGQHSSQAFP--PSLMSKSNSMLQKPTAYVRPMDG 256

  Fly   295 QQPPPPEKDVNKIISDIANIFTVQPLTLIAATPHAPTR---ENYNLLAPNRQKY--AMDIPSSPP 354
                 ||....|:.|:                 |..::   .:.|.|.||.:.:  .:.|||.|.
 Frog   257 -----PESMEPKLSSE-----------------HYSSQSHGSSMNELKPNSKAHLTKLKIPSQPV 299

  Fly   355 SAEPS---SLMTPLFAPITSPIAPLVT---TP--PQASQMPLGGATSGTILAGEALAPLHQLPPT 411
            .|..|   |.:..:...:|....|.:|   ||  .:.|:.|.                     ||
 Frog   300 DASASGDVSCVDEILKEMTHSWPPPLTAIHTPCKTEPSKFPF---------------------PT 343

  Fly   412 MPKAASGVTS-------PGPVKPLKTEKNHSLEKQDSCLENDLELSESEDEQRKKEGRSGGNSSN 469
            .....|...|       |.    .||...|..:   |.|:.||:||.|||        |.|:...
 Frog   344 KDTQQSSFPSCEQKRYNPS----TKTTNGHPTK---SSLKEDLKLSSSED--------SDGDQEC 393

  Fly   470 SSESDSSESGSESSSKNDLQHHPNHQQHHHQLQQQQQQQQATMQQQQVLQQQHRSQPLTSNGAQN 534
            .....::..||...|:|:                                         |.||:|
 Frog   394 DKTMPTNTPGSSEPSQNN-----------------------------------------SEGAEN 417

  Fly   535 KKFRHEIIARGSNTITGLLSSSGFGSGGNVGPAGVNSNAVVGTGSGSGGTLSSGGSSSNKTPSPT 599
            .:       ..|::.:|..||||..|...              .|.|....:....|::..|.|.
 Frog   418 SR-------DDSSSHSGSESSSGSDSESE--------------SSSSDSEANEPSRSASPEPEPP 461

  Fly   600 ESNKWNLSRFFHKPANQTNSESVSP-GNVSMKVPGILPGGAQIIPESIDVTTAIVKNEKNDMAME 663
            .||||.|..:.    |:.|...||| .:|...:|.                             .
 Frog   462 PSNKWQLDNWL----NKGNPHKVSPASSVESNIPS-----------------------------S 493

  Fly   664 EGEEEDDDEEQQLRYGGGLSVTPVAVKKEAIDAVSEMALGAIPKTQIKRESAETLLSARLSDSGT 728
            :|.::|..|:     |.|......:..||                                 |.|
 Frog   494 QGYKKDSQEQ-----GAGTGYAEPSGPKE---------------------------------SNT 520

  Fly   729 SASG-SSSSSSSSSDSAMGGEVVPMPGPGETLQLPGVPAAITTVMRVQPTQSQKAPPSNSVTLTP 792
            |..| .|.::...|:::.|.:..|......|.:        .|:.:.||.:::|:
 Frog   521 STPGRDSKAAQKGSENSRGRQKSPAQSESTTQR--------KTIGKKQPKKTEKS---------- 567

  Fly   793 ILPLPTSPKQRQKKPR---KKKAITSAPILDSSDDDEPPPKHPGLDHTAVSVQTQPATDTVKKGR 854
                      ..:.||   |.:::|:..|..:.    ||.:|
 Frog   568 ----------AVEAPRGGLKIESVTTTEITTNL----PPNRH----------------------- 595

  Fly   855 GRPRKQQQSGGSGNLSSASAGSSSQTKGPTLTAAKKP-LAKTPLAMSRARKREHSSQSSSNGNTP 918
                                  .:.|||     ::|| :.|.|             :||....|.
 Frog   596 ----------------------KAATKG-----SRKPNIKKEP-------------KSSPRPATE 620

  Fly   919 TKKVATPQLVAAPLKPTSNTAGSSSSDEDSSSSAESSSKSSSSSSSSDDTETQNTNCRIVKLNKT 983
            .||.       .|.||              |..:....::.:|||.||:.|:
 Frog   621 RKKY-------KPSKP--------------SQKSREFVETDTSSSDSDENES------------- 651

  Fly   984 GAVQKKALLGSGSSSPSSSGSEAEDQTTRSQVGSGQALAQQLPPYKQLPISQHSQHLSSSDCSSS 1048
                                                     |||..|.|             ..|
 Frog   652 -----------------------------------------LPPSSQTP-------------KYS 662

  Fly  1049 SGGCTAVCSSSSGEEDEGRREKERERKPKSDKNKINTLTRIFNPKEGGAKKQGQVVIVDLQEEQQ 1113
            ....|.....|..|||...|:                  |:|:|.|
 Frog   663 ESNRTPPAKPSVEEEDSFFRQ------------------RLFSPME------------------- 690

  Fly  1114 QGKLDAAAQPSAPQAPPAAPAAIMAKPRMTPTQQQQLGAGLASPARTTTPHLTSLICKIDLSKLS 1178
                  ..:|.:|.:.|                                .....||.|||||.||
 Frog   691 ------EKEPLSPLSEP--------------------------------EERYPLIVKIDLSLLS 717

  Fly  1179 RERIMRLKKLTPAQQNGHLTPKDQATNAVHVPNGYAGDTNPAAKVKHEHPVKPEPELDAGYEAKF 1243
            |                                               .|.:|..|::.....|.
 Frog   718 R-----------------------------------------------IPGRPYKEVEQPKVEKS 735

  Fly  1244 KPGNVKQEFQLKQERDRDRERERERERERERDREREQPPGRRRKRSSSSSSSPYKEKKRKKEKAD 1308
            .|....:|.|.:.::...:.:.:.:..:..|..:.::|. ...|.||..||:....|:...::.|
 Frog   736 APEKHTKESQKQTDKSSTKGKRKHKNDDESRGNDSKKPK-LEEKASSHKSSNKESSKQNPVKEKD 799

  Fly  1309 QLQMGKELLPVPVLLPSNNHERMPNHDRLSYDKLQLLHEDAAAVIGDVSAPNGSPTKKLLAMSPL 1373
            .|....:    ||....:..:.:|....:|  :...|...::..|.:.|:.:.|..|:
 Frog   800 PLPSPAQ----PVQQKDSKTDHIPRKRTVS--QSSSLKSGSSGSIKESSSKSSSSAKQ------- 851

  Fly  1374 PPPPTVTVAPATCNEAVQTTPPSATATSAIA--PPV----PATRLIYRSYFDRDVEHPSDDPRKN 1432
                ..|...:| :.|.:....||.:|:|:|  ||:    ...:|::     .|..|.:|
 Frog   852 ----RKTEGKST-SSAKEPKEKSANSTAAVAFIPPIDNKSQRAKLVF-----EDRIHSAD----- 901

  Fly  1433 NQFLQEAINRKHAADLERDSFNQVTLYLEAVVYFLLTADAMERCSSE-QATNTMYKDTLSLIKFI 1496
             .:||||...||.||...|.|.:...||:|||.|:...:|:|:...| ::...||.:|:.|||:
 Frog   902 -HYLQEAKKLKHNADALSDRFEKAVYYLDAVVSFIECGNALEKSVQESKSPFPMYSETVELIKY- 964

  Fly  1497 STKFRPYQQQSTTNIQHETHNKVAILSLRCQSLISLKLYKLRRKDCRAIINSLTDFFRVGRGDIA 1561
            :.|.:.......|    ....::.:|.||||||:.|:|:||:::.......:||:..   :...:
 Frog   965 TMKLKSSAAPDAT----AADKRLGVLCLRCQSLLYLRLFKLKKESALKYSKTLTEHL---KNSYS 1022

  Fly  1562 NGNTPS----------------SISPSNS---VGSQGSGSNTPPGRIVPPDIHNMLCKQNEFLSY 1607
            |...||                .:||.||   ..|..|.|.:.....:|..||.|.....:..|.
 Frog  1023 NSQAPSPGMGSKSVSMPSPVSPKLSPGNSNNYSSSVSSSSGSTSSVTIPQRIHQMAASYVQVTSN 1087

  Fly  1608 LNSAHELWDQADRLVRTGNHIDFIRELDHENGPLTLH-STMHEVFRYVQAGLKTLR 1662
            ...|.|:||||::|.:..|  ||..|||...|||..: |||.|:.||.:.||..||
 Frog  1088 FLYATEIWDQAEQLCKEQN--DFFTELDKVMGPLIFNSSTMTELVRYTRQGLHWLR 1141

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lilli	NP_523464.1	AF-4_C	1435..1662	CDD:465894	79/247 (32%)
aff4	XP_002935317.3	AF-4	2..473	CDD:461550	135/599 (23%)
		PTZ00449	<532..818	CDD:185628	86/595 (14%)
		AF-4_C	885..1146	CDD:465894	85/278 (31%)