Protein Alignment lilli and aff2

DIOPT Version :10

• Sequence 1: NP_523464.1
• Gene: lilli / 33496
• FlyBaseID: FBgn0041111
• Length: 1673
• Species: Drosophila melanogaster
• Sequence 2: XP_002664429.3
• Gene: aff2 / 100330019
• ZFINID: ZDB-GENE-110411-190
• Length: 1269
• Species: Danio rerio
• Alignment Length: 1768
• Identity: 355/1768 - (20%)
• Similarity: 576/1768 - (32%)
• Gaps: 671/1768 - (37%)

  Fly    54 YSQNYNMEE---YE------RRKRREREKIERQQGIQIDDRETSLFGEPRRLTEGDA---EITAA 106
            :.:::.:|:   ||      ::|..||...|.||...:.....:|||||.:..:|||   .:...
Zfish     8 FFRDWELEQQCHYEQDRSALKKKEWERRTQEVQQDEDLFSTGFNLFGEPYKTNKGDALANRVQNT 72

  Fly   107 LGEFFEAREYI---NNQT--VGISRSAPGAGNPRL------QPNLAPQAK----SLGHSPSSASS 156
            ||.:.|.:|.:   :||:  |||.:::.    |:.      ||...|:|:    :|. .|.|.|:
Zfish    73 LGNYDEMKELLTSHSNQSHLVGIPKNSV----PQTPVEKPDQPGFFPEAQRSRPALS-QPGSHST 132

  Fly   157 AAGPTAASATTSLPG---QQQHYQQQQRPPTYVKQADNKPPYNGRGGYPGQPMKNDIPSSSGM-- 216
            :..|..|:   ::||   ...|..::.|...:           .:||:          .|||:
Zfish   133 SMPPPPAN---TIPGSSVMHGHQSKKSRSSDW-----------SQGGH----------RSSGVQT 173

  Fly   217 --APPRGPPRTSSSNSNSSSVTNNASSGGVPASTPLGPPLSTQMPNGREKSFLGPPAPALHNGTG 279
              |..||...:....||........||     ..|.||..|:.....:.::..||
Zfish   174 TQAASRGKHSSHEQTSNRHDQDQEDSS-----PNPNGPTTSSHSSRKQAQAGKGP---------- 223

  Fly   280 GRFVPPAASKRPGVGQQPPPPEKDVNKIISDIANIFTVQPLTLIAATPHAPTRENYNLLAPNRQK 344
                   |:...|:|:.|..         .|..:..:..||   |:|...|:    .|..|...:
Zfish   224 -------ATAELGLGKSPAE---------QDSCSHGSSSPL---ASTSLLPS----GLSTPTFPQ 265

  Fly   345 YAMDIPSSPPSAEPSSLMTPL----FAPITSP-IAPLVTTPPQASQMPLGG------ATSGT--- 395
            .....|||....:|::.:.|:    ..|..|| :.|.|......:.:|.||      :|:||
Zfish   266 GLHCKPSSAVQQKPTAYVRPMDGQDQVPNDSPELKPPVELVEGYNTVPFGGLLDTKSSTTGTKGK 330

  Fly   396 ------ILAGEALAP---------LHQLPPTMPKAASGVTSPGPVKPLKTEKNHSLEKQDSCLEN 445
                  ..:||...|         |.::..:.|...:.:.:||..:..|..
Zfish   331 IPKLTLPQSGEVSLPNDSNCVEEILREMTHSWPPPLTAIHTPGKAEQTKFP-------------- 381

  Fly   446 DLELSESEDEQRKKEGRSGGNSSNSSESDSSESGSESSS-KNDLQHHPNHQQHHHQLQQQQQQQQ 509
                ..|:|.|....|.:....|..|...:::|..:.|. ::||:...:.:.:
Zfish   382 ----IPSKDSQHVTSGYNAKRCSVPSNKPATKSVPQKSMLEDDLKISSDEEDN------------ 430

  Fly   510 ATMQQQQVLQQQHRSQPLTSNGAQNKKFRHEIIARGSNTITGLLSSSGFGSGGNVGPAGVNSNAV 574
                .|...:.:.||..|...|:                 |.:.||.  .:|.:.|.:|.:|.:.
Zfish   431 ----DQAAEKPKPRSTALNLPGS-----------------TAVRSSE--AAGHSSGASGSSSESE 472

  Fly   575 VGTGSGSGGTLSSGGSSSNK-----TPSPTESNKWNLSRFFHKPANQTNSESVSPGNVSMKVPGI 634
            ..:.|.|....||..|..|:     ||.| |.:||.|.::..|         |:|.|
Zfish   473 SSSESDSDSESSSSDSECNRASRAATPEP-EPSKWQLDKWIKK---------VNPHN-------- 519

  Fly   635 LPGGAQIIPESIDVTTAIVKNEKNDMAMEEGEEEDDDEEQQLRYGGGLSVTPVAVKKEAIDAVSE 699
                           .|::    |..|...|
Zfish   520 ---------------KALI----NTQADSHG---------------------------------- 531

  Fly   700 MALGAIPKTQIKRESAETLLSARLSDSGTSASGSSSSSSSSSDSAMGGEVVPMPGPGETLQLPGV 764
                              |.|::..:|.||.:.|.|.|..|
Zfish   532 ------------------LNSSQPDESQTSENQSYSKSKPS------------------------ 554

  Fly   765 PAAITTVMRVQPTQSQKAPPSNSVTLTPILPLPTSPKQRQKKPRKKKAITSAPILDSSDDDEPPP 829
                        |....|.|.....|:||.. ...||..||.|..|.....:|   :|.:..||.
Zfish   555 ------------TALAPADPKERTLLSPIRE-KAKPKAGQKAPDSKSTKVKSP---ASVELAPPR 603

  Fly   830 KHPGLDHTAVSVQTQPATDTVKKGRGRPRKQQQSGGSGNLSSASAGSSSQT---KGPTLTAAKKP 891
            :                    ..|:.:|:|.::|..|...:....|:||.|   |.|......||
Zfish   604 R--------------------STGKKQPKKVERSSSSEEHNWPRPGNSSSTPKEKEPPPLEPPKP 648

  Fly   892 LAKTPLAMSRARKREHSSQSSSNGNTPTKKVATPQLVAAPLKPTSNTAGSSSSDEDSSSSAESSS 956
            ..|.|:..:..||.                         |...|::||.::.:...........:
Zfish   649 RGKGPVVKTAPRKE-------------------------PRTTTTSTAPTNIAPVPDKKKHRGPN 688

  Fly   957 KSSSSSSSSDDTETQNTNCRIVKLNKTGAVQKKALLGSGSSSPSSSGSEAEDQTTRSQVGSGQAL 1021
            |....|....:||:.::.|.                           |:.|:.|.
Zfish   689 KIIPKSKEFIETESSSSECH---------------------------SDPEELTK---------- 716

  Fly  1022 AQQLPPYKQLPI-SQHSQHLSSSDCSSSSGGCTAVCSSSSGEEDEGRREKERERKPKSDKNKINT 1085
                   .|||. ..::..|.|.||:|:....:::.|:||
Zfish   717 -------VQLPCPGPNTLSLKSKDCNSNILSVSSLTSTSS------------------------- 749

  Fly  1086 LTRIFNPKEGGAKKQGQVVIVDLQEEQQQGKLDAAAQPSAPQAPPAAPAAIMAKPRMTPTQQQQL 1150
             |.|.:|   ||.        ||.||.                        :..|  .|..|.:
Zfish   750 -TSIPDP---GAS--------DLLEEH------------------------LFSP--IPIVQNE- 775

  Fly  1151 GAGLASPARTTTPHLTSLICKIDLSKLSRERIMRLKKLTPAQQNGHLTPKDQATNAVHVPNGYAG 1215
               |.||.| ....:.||..||:||.|||                             :|.
Zfish   776 ---LLSPLR-DFEDIKSLWVKIELSFLSR-----------------------------IPG---- 803

  Fly  1216 DTNPAAKVKHEHPVKPEPELDAGYEAKFKPGNVKQEFQLKQERDRDRERERERERERERDREREQ 1280
                      :.|.:|.|.     :|:.:..:||                          ..|:|
Zfish   804 ----------QDPPEPPPT-----KAECREVSVK--------------------------HRRQQ 827

  Fly  1281 PPGRRRKRSSSSSSSPYKEK-KRKKEKADQLQMGKE--------LLPVPVLLPSNNHERMPNHDR 1336
            .|.     |..:..:|.|.| |.|.|..|.:..||:        ||| |.:.|.:||:.....|.
Zfish   828 SPA-----SIPAEKNPSKSKRKHKSEHCDVMSGGKKLRLDKDTLLLP-PCISPIHNHKVSSTKDS 886

  Fly  1337 LSY------DKL-----------------------QLLHEDAAAVIGDVSAPNGSPTKKLLAMSP 1372
            |..      |||                       .|..|.:.:.|     ||..|:.:.:
Zfish   887 LKKQPRKKDDKLLPPLLSPLSVEPVGRPRRSSECSSLSQEGSTSTI-----PNNLPSSRTI---- 942

  Fly  1373 LPPPPTVTVAPATCNEAVQTT------------PPSATATSAIAPPVPATRLIYRSYFDRDV-EH 1424
                      ||:.:.:..::            ..|.|:|...:...|:.........|.|: .:
Zfish   943 ----------PASSSSSSSSSSHKHRKGENKAFSHSKTSTEEDSHSKPSGGFHGNGQSDADLWSN 997

  Fly  1425 PSD------DPRK-----------NNQFLQEAINRKHAADLERDSFNQVTLYLEAVVYFLLTADA 1472
            ||.      :||:           .:.::|||...||.||...|.|.:...|.:..:.|:...:|
Zfish   998 PSALTMEHMEPRRPKLTFNSTVHSADYYMQEAKKLKHKADALMDKFGKAVNYADGALSFIECGNA 1062

  Fly  1473 MERCSSE-QATNTMYKDTLSLIKFISTKFRPYQQQSTTNIQHETHNKVAILSLRCQSLISLKLYK 1536
            |||...| ::..|||.:|:.||:: :.:.:.:...|.|..:    .|:|:|..||.||:.|:::|
Zfish  1063 MERDPLEAKSPYTMYSETVELIRY-AMRLKNFTSHSATIAE----KKLAVLCNRCLSLLYLRMFK 1122

  Fly  1537 LRRKDCRAIINSLTDFFRVGRGDI-------ANGN-----TPSSISPS--NSVGSQGS--GSNTP 1585
            |::........||.::|:......       |||.     :|.|:|||  :||.|...  ||::.
Zfish  1123 LKKDHAMKYSRSLMEYFKNSAKSSQAPSPWGANGKSTGTPSPMSLSPSPVSSVSSSAGAMGSSSA 1187

  Fly  1586 PGRI-VPPDIHNMLCKQNEFLSYLNSAHELWDQADRLVRTGNHIDFIRELDHENGPLTLHSTMHE 1649
            .|.: :|..||:|........:.:..::|.|:.||:|.:...  :|..|||....|||.||:|.|
Zfish  1188 SGSVAIPQRIHHMAASHVNITNNILRSYEHWETADKLAQESQ--EFFVELDSVMEPLTQHSSMTE 1250

  Fly  1650 VFRYVQAGLKTLR 1662
            :.||::.||..||
Zfish  1251 LVRYIRQGLHWLR 1263

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lilli	NP_523464.1	AF-4_C	1435..1662	CDD:465894	75/244 (31%)
aff2	XP_002664429.3	None