DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Prx6005 and Prdx6

DIOPT Version :9

Sequence 1:	NP_523463.2	Gene:	Prx6005 / 33493	FlyBaseID:	FBgn0031479	Length:	222	Species:	Drosophila melanogaster
Sequence 2:	NP_446028.1	Gene:	Prdx6 / 94167	RGDID:	71005	Length:	224	Species:	Rattus norvegicus

Alignment Length:	220	Identity:	129/220 - (58%)
Similarity:	155/220 - (70%)	Gaps:	3/220 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LNIGDQFPNFTAETSEGRIDFYDWMQDSWAILFSHPADFTPVCTTELSRVAALIPEFQKRGVKPI 70
            |.:||:.|||.|.|:.|.|.|:|::.|||.||||||.||||||||||.|.|.|.|||.||.||.|
  Rat     5 LLLGDEAPNFEANTTIGHIRFHDFLGDSWGILFSHPRDFTPVCTTELGRAAKLAPEFAKRNVKLI 69

  Fly    71 ALSCDTVESHKGWIEDIKSF---GKLSSFDYPIIADDKRELALKFNMLDKDEINAEGIPLTCRAV 132
            |||.|:||.|..|.:||.::   .......:|||.|..|:||:...|||..|.:.:|:|:|.|.|
  Rat    70 ALSIDSVEDHFAWSKDINAYNGAAPTEKLPFPIIDDKDRDLAILLGMLDPAEKDEKGMPVTARVV 134

  Fly   133 FVVDDKKKLRLSILYPATTGRNFDEILRVIDSLQLTQTKSVATPADWKQGGKCMVLPTVKAEDVP 197
            |:....|||:|||||||||||||||||||:||||||.:..||||.|||:|...|||||:..|:..
  Rat   135 FIFGPDKKLKLSILYPATTGRNFDEILRVVDSLQLTASNPVATPVDWKKGESVMVLPTLPEEEAK 199

  Fly   198 KLFPDGIETIELPSGKSYLRITPQP 222
            :|||.|:.|.||||||.|||.||||
  Rat   200 QLFPKGVFTKELPSGKKYLRYTPQP 224

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prx6005	NP_523463.2	PRX_1cys	8..220	CDD:239314	124/214 (58%)
Prx6005	NP_523463.2	AhpC	8..198	CDD:223527	110/192 (57%)
Prdx6	NP_446028.1	AhpC	5..200	CDD:223527	111/194 (57%)
		PRX_1cys	7..222	CDD:239314	124/214 (58%)
		Required and sufficient for targeting to lysosomes and lamellar bodies. /evidence=ECO:0000269\|PubMed:19700648	31..40		7/8 (88%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I11571
eggNOG	1	0.900	-	-		E1_COG0450
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3606
Inparanoid	1	1.050	256	1.000	Inparanoid score	I3079
OMA	1	1.010	-	-		QHG60653
OrthoDB	1	1.010	-	-		D1129256at2759
OrthoFinder	1	1.000	-	-		FOG0002615
OrthoInspector	1	1.000	-	-		oto97123
orthoMCL	1	0.900	-	-		OOG6_100111
Panther	1	1.100	-	-	LDO	PTHR43503
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1721
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840