DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31694 and IFRD2

DIOPT Version :9

Sequence 1:	NP_722858.1	Gene:	CG31694 / 33489	FlyBaseID:	FBgn0051694	Length:	425	Species:	Drosophila melanogaster
Sequence 2:	NP_006755.5	Gene:	IFRD2 / 7866	HGNCID:	5457	Length:	442	Species:	Homo sapiens

Alignment Length:	452	Identity:	164/452 - (36%)
Similarity:	250/452 - (55%)	Gaps:	38/452 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPRRNKKSAAGRG------------RTNDSNSEDESFDNV-SVYSHMSEVASSEATDELA----- 47
            |||..|.:...:|            :.:..:|:||:.... |..|....:.|:.|.|.|.
Human     1 MPRARKGNTLRKGGQRRGGGARSSAQADSGSSDDEAASEARSTASECPSLLSTTAEDSLGGDVVD 65

  Fly    48 ----NERFEEKFEKALEQATEKSAQTRVQALQAICELLMHRYMPDFVEDRKMTLMDFVEKSIRRG 108
                .|..|||.::.::..|:|||:||..||:::...|..|.:|||:.:|::||.|.:||.:::|
Human    66 EQGQQEDLEEKLKEYVDCLTDKSAKTRQGALESLRLALASRLLPDFLLERRLTLADALEKCLKKG 130

  Fly   109 KGQEQVWGARLAPLLVLQMG-GDEG--ISKAMNQFLLNTVQDKSVGFDARAKCCTAVGLLSFLGC 170
            ||:||...|.:..||.:|:| |.:|  :..::...|::.:.|.:....||..|.:|:||..::..
Human   131 KGEEQALAAAVLGLLCVQLGPGPKGEELFHSLQPLLVSVLSDSTASPAARLHCASALGLGCYVAA 195

  Fly   171 EDVGELVHLMQSFEAIFAGSY-LRGDDKTPVSVTAEAGTFHAEALNAWGLLLTLIPSGDFVSLMT 234
            .|:.:||..:...|::|:..| |.|...:||...:..|...| ||.||.||||:.||.....::
Human   196 ADIQDLVSCLACLESVFSRFYGLGGSSTSPVVPASLHGLLSA-ALQAWALLLTICPSTQISHIL- 258

  Fly   235 TGQNMFPSIKKFLGLLQSTHLDVRMAAGETIALILESGRAHEEDFLEDDIAELSEAVKQLATDSH 299
              ....|.:.:   ||.|..:::|:||||||||:.|..|..||:|:.:|:..|...::.|||||:
Human   259 --DRQLPRLPQ---LLSSESVNLRIAAGETIALLFELARDLEEEFVYEDMEALCSVLRTLATDSN 318

  Fly   300 KYRAKRDRKAQRATFRDVLRYLEEDISPEISIRFGTESLTLDSWSIHHQYSAMCTVMGPGMTSQL 364
            |||||.||:.||:|||.||..:|.....|..:|||.|.|.:|||:.|..|:|...|:|.||...|
Human   319 KYRAKADRRRQRSTFRAVLHSVEGGECEEEIVRFGFEVLYMDSWARHRIYAAFKEVLGSGMHHHL 383

  Fly   365 QENEFIRDIFQLGPRPTNTGINGNA--KVKPTKLERHLVNAAAFKARSITRGKNRDKRSAVV 424
            |.||.:||||.|||...   ::..|  ..|..:.|:||.||||||||:..|.:.||||:.::
Human   384 QNNELLRDIFGLGPVLL---LDATALKACKVPRFEKHLYNAAAFKARTKARSRVRDKRADIL 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31694	NP_722858.1	IFRD	21..321	CDD:282813	112/313 (36%)
CG31694	NP_722858.1	IFRD_C	367..421	CDD:282665	26/55 (47%)
IFRD2	NP_006755.5	IFRD	32..341	CDD:398602	113/315 (36%)
IFRD2	NP_006755.5	IFRD_C	386..439	CDD:398486	26/55 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159642
Domainoid	1	1.000	176	1.000	Domainoid score	I3622
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	250	1.000	Inparanoid score	I3235
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59129
OrthoDB	1	1.010	-	-		D1153292at2759
OrthoFinder	1	1.000	-	-		FOG0002385
OrthoInspector	1	1.000	-	-		otm41451
orthoMCL	1	0.900	-	-		OOG6_103218
Panther	1	1.100	-	-	LDO	PTHR12354
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3832
SonicParanoid	1	1.000	-	-		X2973
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.940