DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31694 and IFRD1

DIOPT Version :9

Sequence 1:	NP_722858.1	Gene:	CG31694 / 33489	FlyBaseID:	FBgn0051694	Length:	425	Species:	Drosophila melanogaster
Sequence 2:	NP_001007246.1	Gene:	IFRD1 / 3475	HGNCID:	5456	Length:	451	Species:	Homo sapiens

Alignment Length:	455	Identity:	157/455 - (34%)
Similarity:	235/455 - (51%)	Gaps:	40/455 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPRRNKKSAAGRGRT--------------------------NDSNSEDESFDNVSVYSHMSEVAS 39
            ||:..|::...||.:                          :|.::..|:..:.|.||..|..|.
Human     1 MPKNKKRNTPHRGSSAGGGGSGAAAATAATAGGQHRNVQPFSDEDASIETMSHCSGYSDPSSFAE 65

  Fly    40 S--EATDEL-ANERFEEKFEKALEQATEKSAQTRVQALQAICELLMHRYMPDFVEDRKMTLMDFV 101
            .  |..||. ..|..|.|.:..::...:|||:||..||:.|...|..:.:.:|:.:|:|||.|.:
Human    66 DGPEVLDEEGTQEDLEYKLKGLIDLTLDKSAKTRQAALEGIKNALASKMLYEFILERRMTLTDSI 130

  Fly   102 EKSIRRGKGQEQVWGARLAPLLVLQMG---GDEGISKAMNQFLLNTVQDKSVGFDARAKCCTAVG 163
            |:.:::||..||...|.||.:|.:|:|   ..|.|.|.:...|...:.|.|....||..|.|..|
Human   131 ERCLKKGKSDEQRAAAALASVLCIQLGPGIESEEILKTLGPILKKIICDGSASMQARQTCATCFG 195

  Fly   164 LLSFLGCEDVGELVHLMQSFEAIFAGSYLRGDDKTPVSVTAEAGTFHAEALNAWGLLLTLIPSGD 228
            :..|:..:|:.||...::..|.||..|||:..|.|.:..|... ..|..:|.||.||||:.|..:
Human   196 VCCFIATDDITELYSTLECLENIFTKSYLKEKDTTVICSTPNT-VLHISSLLAWTLLLTICPINE 259

  Fly   229 FVSLMTTGQNMFPSIKKFLGLLQSTHLDVRMAAGETIALILESGRAHEEDFLEDDIAELSEAVKQ 293
            ....:....:..||      ||....:::|:||||::||:.|..|..|.||..:|:..|::.::.
Human   260 VKKKLEMHFHKLPS------LLSCDDVNMRIAAGESLALLFELARGIESDFFYEDMESLTQMLRA 318

  Fly   294 LATDSHKYRAKRDRKAQRATFRDVLRYLEEDISPEISIRFGTESLTLDSWSIHHQYSAMCTVMGP 358
            ||||.:|:|||.|::.||:.||||||.:||...|..:|:||.|.:.:|.|...|.|.....|:|.
Human   319 LATDGNKHRAKVDKRKQRSVFRDVLRAVEERDFPTETIKFGPERMYIDCWVKKHTYDTFKEVLGS 383

  Fly   359 GMTSQLQENEFIRDIFQLGPRPTNTGINGNAKVKPTKLERHLVNAAAFKARSITRGKNRDKRSAV 423
            ||...||.|||:|::|:||| |..........:|.::.||||.|:||||||:..|.|.||||:.|
Human   384 GMQYHLQSNEFLRNVFELGP-PVMLDAATLKTMKISRFERHLYNSAAFKARTKARSKCRDKRADV 447

Fly 424 423
Human 448 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31694	NP_722858.1	IFRD	21..321	CDD:282813	106/305 (35%)
CG31694	NP_722858.1	IFRD_C	367..421	CDD:282665	26/53 (49%)
IFRD1	NP_001007246.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..69		12/67 (18%)
		IFRD	42..346	CDD:282813	107/310 (35%)
		IFRD_C	392..445	CDD:282665	26/53 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159644
Domainoid	1	1.000	176	1.000	Domainoid score	I3622
eggNOG	1	0.900	-	-		E1_KOG2842
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31043
Inparanoid	1	1.050	250	1.000	Inparanoid score	I3235
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59129
OrthoDB	1	1.010	-	-		D1153292at2759
OrthoFinder	1	1.000	-	-		FOG0002385
OrthoInspector	1	1.000	-	-		otm41451
orthoMCL	1	0.900	-	-		OOG6_103218
Panther	1	1.100	-	-	O	PTHR12354
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3832
SonicParanoid	1	1.000	-	-		X2973
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800