DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2991 and Marchf11

DIOPT Version :9

Sequence 1:	NP_608725.1	Gene:	CG2991 / 33488	FlyBaseID:	FBgn0031474	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_808265.2	Gene:	Marchf11 / 211147	MGIID:	3608327	Length:	400	Species:	Mus musculus

Alignment Length:	225	Identity:	47/225 - (20%)
Similarity:	80/225 - (35%)	Gaps:	73/225 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   356 PRKLLSRQIDPSIPTLNAETNKLSPEEGQSFLTKKD----------------------------- 391
            ||:|      |.:....|.|.|.||.|.::...::.
Mouse    98 PRRL------PEVKLPEAATGKGSPGEPEAGACREGERRGTGDQPETRSVCSSRSSSSGGGSDQR 156

  Fly   392 -----------CWICYDSDKPEPLIQPCRCTGDVSSVHHECLKRWLVESCSNSEAQLSCKVCGHP 445
                       |.||:...:...|:.||||.|.|...|..||.:|:.|     ....:|::|.:.
Mouse   157 SGHQHQHHQPICKICFQGAEQGELLNPCRCDGSVRYTHQLCLLKWISE-----RGSWTCELCCYR 216

  Fly   446 YE---IEKSKKLEWDKGFTIQHWSK----TVILITLMCVTGAT--AWVVIQMYV-----DPLVRV 496
            |.   |:..:..:| :..:|....|    .|||.:|..:...|  .|.....|.     |.|.::
Mouse   217 YHVTAIKMKQPCQW-QSISITLVEKVQMIAVILGSLFLIASVTWLLWSAFSPYAVWQRKDILFQI 280

  Fly   497 MTVGIAVLIGYVCVKCLGENTVVAYQRAKV 526
             ..|   :.|::.:.|:|   ::.::.|.|
Mouse   281 -CYG---MYGFMDLVCIG---LIVHEGAAV 303

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2991	NP_608725.1	SSM4	389..>494	CDD:227510	30/158 (19%)
CG2991	NP_608725.1	RING_CH-C4HC3_MARCH	392..443	CDD:319409	16/50 (32%)
Marchf11	NP_808265.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..160		10/67 (15%)
		RINGv	167..213	CDD:128983	16/50 (32%)
		YXXL motif	369..372
		PDZ-binding	397..400
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5183
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810