DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2991 and march4l

DIOPT Version :9

Sequence 1:	NP_608725.1	Gene:	CG2991 / 33488	FlyBaseID:	FBgn0031474	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_001038876.1	Gene:	march4l / 100000640	ZFINID:	ZDB-GENE-060825-323	Length:	421	Species:	Danio rerio

Alignment Length:	366	Identity:	70/366 - (19%)
Similarity:	112/366 - (30%)	Gaps:	159/366 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly   332 IGVALWFPCCLWNSMAPEQLWILNPRKLLSRQ------------------IDPSIPT-------- 370
            |||.:|   | |.        :|:.|.:|.||                  :.|..|:
Zfish     5 IGVIVW---C-WG--------LLSRRPMLRRQGKQKGRCCVLFSDLEVFLLRPPTPSASPPAFTP 57

  Fly   371 ---LNAETNKLS--------------PEEGQSFLTKKD--------------------------- 391
               ||||.|..|              |..|:..|..:.
Zfish    58 MNELNAEGNATSSATESHSLANGHYQPVTGEEALDTRGPDDWTHSVVDPPRTLDCCSSSEDCSKE 122

  Fly   392 --------------------CWICYDSDKPEPLIQPCRCTGDVSSVHHECLKRWLVESCSNSEAQ 436
                                |.||:...:...|:.||||:|.|...|..||.:|:.|     ...
Zfish   123 KLDERLSLNSCTDSGVRTPLCRICFQGPEQGELLSPCRCSGSVRCTHEPCLIKWISE-----RGS 182

  Fly   437 LSCKVCGHPYE---IEKSKKLEWDKGFTIQHWSKTVI--------LITLMCVTGATAWVVIQMYV 490
            .||::|.:.|:   |.....|:|      |..|.|||        ::..:.:..:.:|:|... :
Zfish   183 WSCELCYYKYQVIAISTKNPLQW------QAISLTVIEKVQIAAAVLGSLFLIASISWLVWSS-L 240

  Fly   491 DPLVRVMTVGIAVLIGY--------VCVKCL---GENT---------------VVAYQRAKVSSI 529
            .|..:.....:...|.|        ||:..:   |.:.               |:.|.:.|.:..
Zfish   241 SPSAKWQRQDLLFQICYAMYGFMDLVCIALIVHEGPSVFRIFNRWQAVNQQWKVLNYDKVKDNED 305

  Fly   530 NIVTSSEMEKL-----HTICE---EVSASTSAEAVRAGAAS 562
            :..|.:....|     |.:.:   |...|||..::.|.||:
Zfish   306 HQKTGATFRTLSLPLTHRMGQSGPEGEPSTSTSSLMAAAAA 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2991	NP_608725.1	SSM4	389..>494	CDD:227510	30/162 (19%)
CG2991	NP_608725.1	RING_CH-C4HC3_MARCH	392..443	CDD:319409	17/50 (34%)
march4l	NP_001038876.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..79		6/18 (33%)
		RINGv	143..188	CDD:128983	17/49 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	319..385		8/28 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	401..421
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5183
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810