DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3104 and Tnks2

DIOPT Version :9

Sequence 1:	NP_001259969.1	Gene:	CG3104 / 33486	FlyBaseID:	FBgn0031473	Length:	321	Species:	Drosophila melanogaster
Sequence 2:	NP_001157107.1	Gene:	Tnks2 / 74493	MGIID:	1921743	Length:	1166	Species:	Mus musculus

Alignment Length:	464	Identity:	112/464 - (24%)
Similarity:	170/464 - (36%)	Gaps:	157/464 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KKETPSDVQLHMAAMRGDEVALLRVLDSGKVHVDCKDEDGTTPLILAAAGGHTYCVMELLDQGAD 68
            :|.||    ||.||..|.:..:..:|.:| .:|..:|:.|..||..|.:.||...|..||..|||
Mouse    57 RKSTP----LHFAAGFGRKDVVEYLLQNG-ANVQARDDGGLIPLHNACSFGHAEVVNLLLQHGAD 116

  Fly    69 PNSRRLTGTTPLFFAAQGGHLDVVKILIKAGA--------------------------------- 100
            ||:|.....|||..||..|.:||..:|::.||
Mouse   117 PNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGDYKKDEL 181

  Fly   101 -------------------SVDTPSADG--GTPLFVACQGGHVKIVRELLDCGANVNAHMKDRAT 144
                               :|:..::||  .|||.:|.....||||:.||..||:|:|..|....
Mouse   182 LESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLHHGADVHAKDKGDLV 246

  Fly   145 PVFISAQNGHRTVLSLLIQAGAEIDIKRIDGATPLWIAAQMG----------------------- 186
            |:..:...||..|..||::.||.::...:...|||..||...
Mouse   247 PLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRIEVCSLLLSYGADPTLLNCHNK 311

  Fly   187 --------------------------------------------------QDH------------ 189
                                                              |.|
Mouse   312 SAIDLAPTAQLKERLSYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPY 376

  Fly   190 -----ICKVLLQNGANVDTVRCDGATPLFKAAHKGHAAVITVLLKYRPNLGQLPN-GESALHAAA 248
                 ||::||:.|||.:....:..|||..|:...|..|:.|::|:...:..|.: |:::||.||
Mouse   377 PKRKQICELLLRKGANTNEKTKEFLTPLHVASENAHNDVVEVVVKHEAKVNALDSLGQTSLHRAA 441

  Fly   249 MFGHMTVCKQLVAAGSDVLLKNHDGLTALQLAHQQKYTSICDYLQERI---RTMVARSAKAMATS 310
            ..||:..|:.|::.|.|..:.:..|.||||:.::    ::...|||..   .:...|.....|.:
Mouse   442 HCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNE----NVQQLLQEGASLGHSEADRQLLEAAKA 502

  Fly   311 GVSSTVKTM 319
            |...|||.:
Mouse   503 GDVETVKKL 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3104	NP_001259969.1	Ank_2	<13..72	CDD:289560	23/58 (40%)
		ANK repeat	13..40	CDD:293786	8/26 (31%)
		ANK	37..162	CDD:238125	50/178 (28%)
		ANK repeat	42..73	CDD:293786	14/30 (47%)
		Ank_2	47..137	CDD:289560	40/143 (28%)
		ANK repeat	75..106	CDD:293786	12/82 (15%)
		ANK	103..228	CDD:238125	46/216 (21%)
		ANK repeat	108..137	CDD:293786	15/30 (50%)
		Ank_2	113..202	CDD:289560	35/178 (20%)
		ANK repeat	141..171	CDD:293786	8/29 (28%)
		ANK	169..292	CDD:238125	39/213 (18%)
		ANK repeat	174..204	CDD:293786	14/119 (12%)
		Ank_2	179..270	CDD:289560	32/181 (18%)
		ANK repeat	207..237	CDD:293786	8/29 (28%)
		ANK repeat	239..270	CDD:293786	11/31 (35%)
Tnks2	NP_001157107.1	ANK 1	23..52
		Ank_4	28..78	CDD:290365	8/24 (33%)
		ANK	50..164	CDD:238125	38/111 (34%)
		ANK 2	57..86		11/33 (33%)
		ANK repeat	60..88	CDD:293786	10/32 (31%)
		Ank_2	62..154	CDD:289560	35/92 (38%)
		ANK repeat	90..121	CDD:293786	14/30 (47%)
		ANK 3	90..119		13/28 (46%)
		ANK repeat	123..154	CDD:293786	11/30 (37%)
		ANK 4	123..152		11/28 (39%)
		ANK	203..317	CDD:238125	30/113 (27%)
		ANK 5	210..239		13/28 (46%)
		ANK repeat	213..241	CDD:293786	14/27 (52%)
		Ank_2	215..307	CDD:289560	26/91 (29%)
		ANK repeat	243..274	CDD:293786	8/30 (27%)
		ANK 6	243..272		8/28 (29%)
		ANK repeat	276..307	CDD:293786	5/30 (17%)
		ANK 7	276..305		5/28 (18%)
		ANK 8	363..395		8/31 (26%)
		ANK repeat	365..397	CDD:293786	7/31 (23%)
		Ank_2	368..461	CDD:289560	27/92 (29%)
		ANK	394..579	CDD:238125	34/122 (28%)
		ANK repeat	399..430	CDD:293786	8/30 (27%)
		ANK 9	399..428		8/28 (29%)
		ANK 10	432..461		11/28 (39%)
		ANK repeat	433..521	CDD:293786	25/83 (30%)
		Ank_2	437..556	CDD:289560	24/79 (30%)
		ANK 11	463..489		8/29 (28%)
		ANK	518..643	CDD:238125
		ANK 12	525..554
		ANK repeat	528..556	CDD:293786
		Ank_2	530..622	CDD:289560
		HIF1AN-binding. /evidence=ECO:0000250\|UniProtKB:Q9H2K2	545..553
		ANK repeat	558..589	CDD:293786
		ANK 13	558..587
		ANK repeat	591..622	CDD:293786
		ANK 14	591..620
		ANK 15	624..652
		ANK repeat	644..674	CDD:293786
		ANK	671..787	CDD:238125
		ANK 16	678..707
		ANK repeat	681..709	CDD:293786
		Ank_2	683..775	CDD:289560
		ANK repeat	711..742	CDD:293786
		ANK 17	711..740
		ANK repeat	744..775	CDD:293786
		ANK 18	744..773
		SAM_tankyrase1,2	871..936	CDD:188923
		SAM	877..933	CDD:197735
		tankyrase_like	938..1160	CDD:238718
		PARP	952..1155	CDD:279038
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900