DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3104 and Asb12

DIOPT Version :9

Sequence 1:	NP_001259969.1	Gene:	CG3104 / 33486	FlyBaseID:	FBgn0031473	Length:	321	Species:	Drosophila melanogaster
Sequence 2:	NP_001300672.1	Gene:	Asb12 / 70392	MGIID:	1917642	Length:	308	Species:	Mus musculus

Alignment Length:	326	Identity:	82/326 - (25%)
Similarity:	138/326 - (42%)	Gaps:	76/326 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 LRVLDSGKV----HVDCKDED---GTTPLILAAAGGHTYCVME-LLDQGADP---NSRRLTGT-- 77
            :.::|..|:    ..:.::||   |....:..|...:..|.:: ||.|....   |||...|.
Mouse     1 MNLMDIAKIFSLLQPEKEEEDTGTGEKQALNQAVYDNDSCTLDHLLHQERYKRFINSRSGWGIPG 65

  Fly    78 TPLFFAAQGGHLDVVKILIKAGASVDTPSADGGTPLFVACQGGHVKIVRELLDCGANVNAHMKDR 142
            |||..||..|||:.||:|::.||.||:......||||.|...||::.||.||:.||..:..:.:.
Mouse    66 TPLRLAASYGHLNCVKVLLEHGADVDSLDVKAQTPLFTAVSHGHLECVRMLLEAGACPSGSIYNN 130

  Fly   143 ATPVFISAQNGHRTVLSLLIQAGAEIDIKRIDGATPLWIAAQMGQDHICKVLLQNGANVDTVRCD 207
            .:||..::::|...:|..|:..|||.::|   ...|:|                 .:|:  ..|.
Mouse   131 CSPVLTASRDGAFAILQELLGHGAEANVK---AKLPVW-----------------ASNI--ASCS 173

  Fly   208 GATPLFKAAHKGHAAVITVLLKYRPN----------LGQLPNGESALHAAAMFGHMTVC------ 256
            |  ||:.||..||.....:||.|..:          |.::|...:.|.         :|
Mouse   174 G--PLYLAAVYGHLDCFRLLLLYGADPDYNCTDQGLLSRVPQPRTLLE---------ICLHHNCE 227

  Fly   257 ----KQLVAAGSDVLL-------KNHDGLTALQLAHQQKYT--SICDYLQERIRTMVARSAKAMA 308
                :.|:..|:::.|       .:.|. ..::|..|.:.|  |:....:..||..:.|:.::.|
Mouse   228 PEYIQLLIDFGANIYLPSLPVDPTSQDD-KGIKLLLQARATPRSLLSQTRLVIRRSLCRANQSQA 291

  Fly   309 T 309
            |
Mouse   292 T 292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3104	NP_001259969.1	Ank_2	<13..72	CDD:289560	11/56 (20%)
		ANK repeat	13..40	CDD:293786	2/17 (12%)
		ANK	37..162	CDD:238125	44/133 (33%)
		ANK repeat	42..73	CDD:293786	9/37 (24%)
		Ank_2	47..137	CDD:289560	37/95 (39%)
		ANK repeat	75..106	CDD:293786	16/32 (50%)
		ANK	103..228	CDD:238125	34/124 (27%)
		ANK repeat	108..137	CDD:293786	13/28 (46%)
		Ank_2	113..202	CDD:289560	23/88 (26%)
		ANK repeat	141..171	CDD:293786	8/29 (28%)
		ANK	169..292	CDD:238125	27/151 (18%)
		ANK repeat	174..204	CDD:293786	3/29 (10%)
		Ank_2	179..270	CDD:289560	20/117 (17%)
		ANK repeat	207..237	CDD:293786	11/39 (28%)
		ANK repeat	239..270	CDD:293786	5/47 (11%)
Asb12	NP_001300672.1	PHA02875	25..>259	CDD:165206	69/267 (26%)
		ANK 1	63..92		14/28 (50%)
		ANK repeat	66..94	CDD:293786	15/27 (56%)
		Ank_2	68..159	CDD:372319	34/90 (38%)
		ANK repeat	96..160	CDD:293786	22/66 (33%)
		ANK 2	96..125		13/28 (46%)
		ANK 3	129..158		8/28 (29%)
		ANK 4	171..200		11/30 (37%)
		ANK repeat	173..199	CDD:293786	10/27 (37%)
		ANK 5	213..243		4/38 (11%)
		SOCS_box	268..306	CDD:369403	6/25 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24120
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010