DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3104 and Ankdd1a

DIOPT Version :9

Sequence 1:	NP_001259969.1	Gene:	CG3104 / 33486	FlyBaseID:	FBgn0031473	Length:	321	Species:	Drosophila melanogaster
Sequence 2:	NP_001357800.1	Gene:	Ankdd1a / 330963	MGIID:	2686319	Length:	519	Species:	Mus musculus

Alignment Length:	288	Identity:	85/288 - (29%)
Similarity:	138/288 - (47%)	Gaps:	4/288 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 PSDVQLHMAAMRGDEVALLRVLDSGKVHVDCKDEDGTTPLILAAAGGHTYCVMELLDQGADPNSR 72
            |.:.|||.|: |.::|..::.|...:|::..::..|...|..||..||...|..||::||..:..
Mouse    14 PLERQLHEAS-RWNQVERMKELFEKRVNIRARNHVGRVALHWAAGAGHEQAVRLLLERGAAVDDV 77

  Fly    73 RLTGTTPLFFAAQGGHLDVVKILIKAGASVDTPSADGGTPLFVACQGGHVKIVRELLDCGANVNA 137
            ...|...|..:|..|||.:|:||:.|||.|...|.||.|.|..|.|.|||.::..:::...:|..
Mouse    78 DSFGMNSLLLSAWFGHLQIVQILVNAGAKVHCESKDGLTLLHCAAQKGHVPVLAFVMEDLEDVAL 142

  Fly   138 HMKDR--ATPVFISAQNGHRTVLSLLIQAGAEIDIKRIDGATPLWIAAQMGQDHICKVLLQNGAN 200
            ...|:  .|....:|::|....|..|:.:|.:..:|...|.|.|.:||..|...:.:.|:..|.:
Mouse   143 DHADKLGRTAFHRAAEHGQLDALDFLVGSGCDHSVKDKGGNTALHLAASQGHVDVLQRLVDIGLD 207

  Fly   201 VDTVRCDGATPLFKAAHKGHAAVITVLLKYRPNLGQLPNGE-SALHAAAMFGHMTVCKQLVAAGS 264
            ::....:|.|.|..||...||..:.:||....|:..|.... |.||.||:.|...:.:.|:.||.
Mouse   208 LEEQNTEGLTALHAAAEGIHADCVMLLLGAGSNVNALTQKRLSCLHYAALGGSEDLSRALIKAGG 272

  Fly   265 DVLLKNHDGLTALQLAHQQKYTSICDYL 292
            ...:.:..|.|.:.||.:..:..:...|
Mouse   273 CTNVADKQGTTPMHLAVKHNFPGLVQLL 300

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3104	NP_001259969.1	Ank_2	<13..72	CDD:289560	18/58 (31%)
		ANK repeat	13..40	CDD:293786	7/26 (27%)
		ANK	37..162	CDD:238125	40/126 (32%)
		ANK repeat	42..73	CDD:293786	11/30 (37%)
		Ank_2	47..137	CDD:289560	34/89 (38%)
		ANK repeat	75..106	CDD:293786	13/30 (43%)
		ANK	103..228	CDD:238125	34/126 (27%)
		ANK repeat	108..137	CDD:293786	10/28 (36%)
		Ank_2	113..202	CDD:289560	23/90 (26%)
		ANK repeat	141..171	CDD:293786	7/31 (23%)
		ANK	169..292	CDD:238125	33/123 (27%)
		ANK repeat	174..204	CDD:293786	8/29 (28%)
		Ank_2	179..270	CDD:289560	26/91 (29%)
		ANK repeat	207..237	CDD:293786	10/29 (34%)
		ANK repeat	239..270	CDD:293786	9/31 (29%)
Ankdd1a	NP_001357800.1	Ank_2	19..108	CDD:372319	30/89 (34%)
		ANK repeat	19..45	CDD:293786	7/26 (27%)
		ANK repeat	47..78	CDD:293786	11/30 (37%)
		ANK repeat	80..110	CDD:293786	13/29 (45%)
		PHA03095	96..>368	CDD:222980	59/205 (29%)
		ANK repeat	113..146	CDD:293786	10/32 (31%)
		ANK repeat	149..179	CDD:293786	6/29 (21%)
		ANK repeat	181..212	CDD:293786	8/30 (27%)
		ANK repeat	214..243	CDD:293786	10/28 (36%)
		ANK repeat	250..278	CDD:293786	9/27 (33%)
		ANK repeat	280..311	CDD:293786	5/21 (24%)
		ANK repeat	313..344	CDD:293786
		DD	420..491	CDD:387368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53592
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910