DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3104 and ANK3

DIOPT Version :9

Sequence 1:	NP_001259969.1	Gene:	CG3104 / 33486	FlyBaseID:	FBgn0031473	Length:	321	Species:	Drosophila melanogaster
Sequence 2:	NP_066267.2	Gene:	ANK3 / 288	HGNCID:	494	Length:	4377	Species:	Homo sapiens

Alignment Length:	329	Identity:	101/329 - (30%)
Similarity:	157/329 - (47%)	Gaps:	41/329 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KKETPSD------VQLHMAAMRGDEVALLRVLDSGKVHVDCKDEDGTTPLILAAAGGHTYCVMEL 62
            ||..|:.      ..||:|..: :.:.::.:|......:....|.|.||:.:||..||...|.:|
Human   389 KKANPNAKALNGFTPLHIACKK-NRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQL 452

  Fly    63 LDQGADPNSRRLTGTTPLFFAAQGGHLDVVKILIKAGASVDTPSADGGTPLFVACQGGHVKIVRE 127
            :..||.||:..:.|.|.|..||:.|..:||:.|::.||.|:..:.|..|||.::.:.|...||::
Human   453 MHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQ 517

  Fly   128 LLDCGANVNAHMKDRATPVFISAQNGHRTVLSLLIQAGAEIDIKRIDGATPLWIAAQMGQDHICK 192
            ||..||:.||......||:.:||:.||..|.:.|:..||.:.|....|.|||.:||:.|:..:..
Human   518 LLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVAN 582

  Fly   193 VLLQNGANVDTVRCDGATPLFKAAH---------------KGHAA------------------VI 224
            :|||..|:.|.....|.|||..|||               ..|||                  :.
Human   583 LLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIA 647

  Fly   225 TVLLKYRPNLGQLP-NGESALHAAAMFGHMTVCKQLVAAGSDVLLKNHDGLTALQLAHQQKYTSI 288
            |.||:|..:...:. .|.:::|.||..||:.:...|:...::|.|.|..|||.|.||.|:...::
Human   648 TTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNV 712

  Fly   289 CDYL 292
            .:.|
Human   713 AEVL 716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3104	NP_001259969.1	Ank_2	<13..72	CDD:289560	18/58 (31%)
		ANK repeat	13..40	CDD:293786	4/26 (15%)
		ANK	37..162	CDD:238125	46/124 (37%)
		ANK repeat	42..73	CDD:293786	13/30 (43%)
		Ank_2	47..137	CDD:289560	33/89 (37%)
		ANK repeat	75..106	CDD:293786	12/30 (40%)
		ANK	103..228	CDD:238125	47/157 (30%)
		ANK repeat	108..137	CDD:293786	11/28 (39%)
		Ank_2	113..202	CDD:289560	32/88 (36%)
		ANK repeat	141..171	CDD:293786	10/29 (34%)
		ANK	169..292	CDD:238125	44/156 (28%)
		ANK repeat	174..204	CDD:293786	12/29 (41%)
		Ank_2	179..270	CDD:289560	32/124 (26%)
		ANK repeat	207..237	CDD:293786	14/62 (23%)
		ANK repeat	239..270	CDD:293786	9/30 (30%)
ANK3	NP_066267.2	ANK 6	234..263
		ANK repeat	267..298	CDD:293786
		ANK 7	267..296
		Ank_2	272..363	CDD:289560
		ANK	295..420	CDD:238125	6/31 (19%)
		ANK 8	300..329
		ANK repeat	300..325	CDD:293786
		ANK repeat	333..364	CDD:293786
		ANK 9	333..362
		ANK	361..486	CDD:238125	29/97 (30%)
		ANK 10	366..395		3/5 (60%)
		ANK repeat	369..397	CDD:293786	3/7 (43%)
		Ank_2	371..463	CDD:289560	21/74 (28%)
		ANK repeat	399..430	CDD:293786	4/31 (13%)
		ANK 11	399..428		4/29 (14%)
		ANK repeat	432..463	CDD:293786	13/30 (43%)
		ANK 12	432..461		12/28 (43%)
		ANK	460..585	CDD:238125	44/124 (35%)
		ANK repeat	465..496	CDD:293786	12/30 (40%)
		ANK 13	465..494		12/28 (43%)
		Ank_2	470..561	CDD:289560	33/90 (37%)
		ANK repeat	498..529	CDD:293786	13/30 (43%)
		ANK 14	498..527		11/28 (39%)
		ANK repeat	531..560	CDD:293786	10/28 (36%)
		ANK 15	531..560		10/28 (36%)
		Ank_2	536..626	CDD:289560	28/89 (31%)
		ANK	560..684	CDD:238125	33/123 (27%)
		ANK repeat	564..593	CDD:293786	11/28 (39%)
		ANK 16	564..593		11/28 (39%)
		ANK repeat	597..626	CDD:293786	7/28 (25%)
		ANK 17	597..626		7/28 (25%)
		ANK repeat	630..660	CDD:293786	4/29 (14%)
		ANK 18	630..659		4/28 (14%)
		Ank_4	631..684	CDD:290365	10/52 (19%)
		ANK	658..783	CDD:238125	18/59 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44
		Ank_4	47..94	CDD:290365
		ANK	68..193	CDD:238125
		ANK repeat	73..104	CDD:293786
		ANK 1	73..102
		Ank_2	78..164	CDD:289560
		ANK repeat	106..137	CDD:293786
		ANK 2	106..135
		ANK 3	139..168
		ANK repeat	139..164	CDD:293786
		Ank_4	140..193	CDD:290365
		ANK 4	172..201
		ANK 5	203..230
		ANK repeat	205..232	CDD:293786
		Ank_2	206..297	CDD:289560
		ANK	229..354	CDD:238125
		ANK repeat	234..265	CDD:293786
		ANK repeat	663..694	CDD:293786	9/30 (30%)
		ANK 19	663..692		8/28 (29%)
		Ank_2	669..759	CDD:289560	17/48 (35%)
		ANK repeat	696..727	CDD:293786	8/21 (38%)
		ANK 20	696..725		8/21 (38%)
		ANK repeat	729..760	CDD:293786
		ANK 21	729..758
		Ank_5	749..803	CDD:290568
		ANK 22	762..791
		ANK repeat	762..790	CDD:293786
		ANK 23	795..825
		ZU5	982..1086	CDD:128514
UPA domain. /evidence=ECO:0000250	1273..1407
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1519..1540
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1968..1987
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2107..2159
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2176..2245
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2299..2322
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2383..2433
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2474..2508
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2588..2751
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2795..2824
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3036..3067
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3131..3272
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3298..3516
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3538..3607
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3635..3718
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3868..3897
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4019..4090
Death_ank3	4088..4171	CDD:176781
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4251..4298
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4323..4377
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810