DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3104 and Ankle1

DIOPT Version :9

Sequence 1:	NP_001259969.1	Gene:	CG3104 / 33486	FlyBaseID:	FBgn0031473	Length:	321	Species:	Drosophila melanogaster
Sequence 2:	NP_766344.2	Gene:	Ankle1 / 234396	MGIID:	1918775	Length:	534	Species:	Mus musculus

Alignment Length:	184	Identity:	50/184 - (27%)
Similarity:	74/184 - (40%)	Gaps:	26/184 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 MAAMRGDEV----ALLRVLDSGKVHVDCKDEDGTTPLILAAAGGH---TYCVMELLDQGADPNSR 72
            :||:|.:|.    .|||:.....:.:|    ||...:.|||...|   .:|:..||..|||||:|
Mouse    12 LAALREEEARAVEELLRLGADPNLVLD----DGAAAVHLAARASHPRALHCLRMLLRWGADPNAR 72

  Fly    73 RLTGTTPLFFAAQGGHLDVVKILIKAGASVDTPSADGGTPLFVACQGGHVKIVRELLDCGANVNA 137
            ...|.||:..||..|....:::|:..|........||..||..|.|..|....|.|.:.......
Mouse    73 SAEGLTPVHVAAAWGCCGALELLLSRGGDPTLRDQDGLRPLDWALQQRHHNCARVLQELDTPTQP 137

  Fly   138 HMKDRATPVFISAQNGHRTVL----SLLIQAG-----------AEIDIKRIDGA 176
            ......|..|..||....|..    :|...:|           ||::::.::.|
Mouse   138 DETREPTETFHVAQGSFETETCQGPALAESSGVSQDSELHVHRAELEVEAVEVA 191

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3104	NP_001259969.1	Ank_2	<13..72	CDD:289560	22/63 (35%)
		ANK repeat	13..40	CDD:293786	8/28 (29%)
		ANK	37..162	CDD:238125	39/131 (30%)
		ANK repeat	42..73	CDD:293786	14/33 (42%)
		Ank_2	47..137	CDD:289560	30/92 (33%)
		ANK repeat	75..106	CDD:293786	8/30 (27%)
		ANK	103..228	CDD:238125	19/89 (21%)
		ANK repeat	108..137	CDD:293786	9/28 (32%)
		Ank_2	113..202	CDD:289560	16/79 (20%)
		ANK repeat	141..171	CDD:293786	9/44 (20%)
		ANK	169..292	CDD:238125	1/8 (13%)
		ANK repeat	174..204	CDD:293786	1/3 (33%)
		Ank_2	179..270	CDD:289560
		ANK repeat	207..237	CDD:293786
		ANK repeat	239..270	CDD:293786
Ankle1	NP_766344.2	ANK 1. /evidence=ECO:0000255	4..35		7/22 (32%)
		ANK	26..128	CDD:238125	35/105 (33%)
		Ank_2	26..106	CDD:289560	27/83 (33%)
		ANK 2. /evidence=ECO:0000255	39..71		13/31 (42%)
		ANK repeat	75..106	CDD:293786	8/30 (27%)
		ANK 3. /evidence=ECO:0000255	75..104		8/28 (29%)
		Ank_4	76..128	CDD:290365	16/51 (31%)
		ANK 4. /evidence=ECO:0000255	108..137		9/28 (32%)
		LEM	285..322	CDD:295412
		GIY-YIG_COG3680_Meta	372..484	CDD:198401
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:Q8NAG6	498..505
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900