DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3104 and ANKAR

DIOPT Version :9

Sequence 1:	NP_001259969.1	Gene:	CG3104 / 33486	FlyBaseID:	FBgn0031473	Length:	321	Species:	Drosophila melanogaster
Sequence 2:	XP_011508975.1	Gene:	ANKAR / 150709	HGNCID:	26350	Length:	1445	Species:	Homo sapiens

Alignment Length:	359	Identity:	83/359 - (23%)
Similarity:	127/359 - (35%)	Gaps:	95/359 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLKKETPSDVQLH---------MAAMR------GDEVALLRVLDSGKVH----------VDCKD 40
            :.||:...:|.|||         ..||:      |.:.|:.|.| |...|          ::..|
Human   467 LRLKRLPLTDAQLHEQFKKKLGFKRAMKCKSIPFGMKSAVERGL-SAVFHTFSRKTSSSTINVSD 530

  Fly    41 EDGTTPLILAAAGGHTYCVMELLDQGADPNSRRLT----GTTPLFFAAQGGHLDVVKILIKAGAS 101
            |.|.|....||.......:.:|.:.....|.||..    |.|||..|||...|:....|:.:.|.
Human   531 EAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSLETTVCLLCSKAD 595

  Fly   102 VDTPSADGGTPLFVACQGGHVKIVRELLDCGANVNAHMKDRATPVFISAQNGHRTVLSLLIQAGA 166
            .......|..|:..|....:|.|:..|  |          |..|..:.|            :|.|
Human   596 YTLSEKRGWMPIHFAAFYDNVCIIIAL--C----------RKDPSLLEA------------EATA 636

  Fly   167 EIDIKRIDGATPLWIAAQMGQDHICKVLLQNGANVDTVRCDGATPLFKAAHKGHAAVITV---LL 228
            |      :..|||.:||..|.....:.|...|||.......|...:       |.:|:|.   :|
Human   637 E------NQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNII-------HLSVLTFHTEVL 688

  Fly   229 KY--RPNLGQLPNGESALHAAAMFGHMTVC----KQLVAAGSDVLLKNHDGLTALQLAHQQKYTS 287
            ||  :.|:.:||..::.:       .|..|    ::::|..|         |..:.||:.|.:..
Human   689 KYIIKLNIPELPVWKTLV-------EMLQCESYKRRMMAVMS---------LEVICLANDQYWRC 737

  Fly   288 ICD--YLQERIRTMVARSAKAMA-TSGVSSTVKT 318
            |.|  .:...|..:.:...|... |.|:.|.:.|
Human   738 ILDAGTIPALINLLKSSKIKLQCKTVGLLSNIST 771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3104	NP_001259969.1	Ank_2	<13..72	CDD:289560	18/83 (22%)
		ANK repeat	13..40	CDD:293786	10/51 (20%)
		ANK	37..162	CDD:238125	30/128 (23%)
		ANK repeat	42..73	CDD:293786	6/30 (20%)
		Ank_2	47..137	CDD:289560	23/93 (25%)
		ANK repeat	75..106	CDD:293786	10/34 (29%)
		ANK	103..228	CDD:238125	27/127 (21%)
		ANK repeat	108..137	CDD:293786	7/28 (25%)
		Ank_2	113..202	CDD:289560	21/88 (24%)
		ANK repeat	141..171	CDD:293786	6/29 (21%)
		ANK	169..292	CDD:238125	30/133 (23%)
		ANK repeat	174..204	CDD:293786	10/29 (34%)
		Ank_2	179..270	CDD:289560	22/99 (22%)
		ANK repeat	207..237	CDD:293786	8/34 (24%)
		ANK repeat	239..270	CDD:293786	4/34 (12%)
ANKAR	XP_011508975.1	Ank_2	505..598	CDD:289560	25/93 (27%)
		ANK	527..658	CDD:238125	39/160 (24%)
		ANK repeat	533..567	CDD:293786	8/33 (24%)
		ANK repeat	570..600	CDD:293786	10/29 (34%)
		Ank_2	574..669	CDD:289560	30/124 (24%)
		ANK repeat	602..636	CDD:293786	11/57 (19%)
		ANK repeat	638..663	CDD:293786	7/24 (29%)
		ARM	<678..771	CDD:237987	23/108 (21%)
		armadillo repeat	703..727	CDD:293788	5/39 (13%)
		armadillo repeat	737..769	CDD:293788	7/31 (23%)
		ARM	738..851	CDD:237987	8/34 (24%)
		armadillo repeat	776..812	CDD:293788
		armadillo repeat	816..850	CDD:293788
		ARM	817..947	CDD:237987
		armadillo repeat	858..898	CDD:293788
		armadillo repeat	1005..1029	CDD:293788
		armadillo repeat	1037..1075	CDD:293788
		ARM	1039..1166	CDD:237987
		armadillo repeat	1086..1121	CDD:293788
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900