DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3104 and ank3b

DIOPT Version :9

Sequence 1:	NP_001259969.1	Gene:	CG3104 / 33486	FlyBaseID:	FBgn0031473	Length:	321	Species:	Drosophila melanogaster
Sequence 2:	XP_021335899.1	Gene:	ank3b / 100126016	ZFINID:	ZDB-GENE-060621-2	Length:	3985	Species:	Danio rerio

Alignment Length:	372	Identity:	109/372 - (29%)
Similarity:	165/372 - (44%)	Gaps:	77/372 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LHMAAMRGDEVALLRVLDSGKVHVDCKDEDGTTPLILAAAGGHTYCVMELLDQGADPNSRRLTGT 77
            ||:|:..|....:..::..|.. ||...:.|.|.|.:|:..|....|.||::.||:.|::...|.
Zfish    77 LHLASKEGHVEVVTELIKLGAT-VDAATKKGNTALHIASLAGQADVVKELVNNGANINAQSQNGF 140

  Fly    78 TPLFFAAQGGHLDVVKILIKAGASVDTPSADGGTPLFVACQGGHVKIVRELL------------- 129
            |||:.|||..||||||.|:..|:|....:.||.|||.||.|.||.::|..||
Zfish   141 TPLYMAAQENHLDVVKFLLDNGSSQSIATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPAL 205

  Fly   130 ------------------DCGANVNAHM------KDRATPVFISAQNGHRTVLSLLIQAGAEIDI 170
                              |..|::.:.|      :...||:.|:|..|:..|.:||:..||.:|.
Zfish   206 HIAARKDDTKAAALLLQNDHNADIESKMMVNRTTESGFTPLHIAAHYGNINVATLLLNRGAAVDF 270

  Fly   171 KRIDGATPLWIAAQMGQDHICKVLLQNGANVDTVRCDGATPLFKAAHKGHAAVITVLL-KYRPNL 234
            |..:..|||.:|::.|..::.::||:.||.:|....||.|||...|..||..|:.:|| :..|.|
Zfish   271 KARNDITPLHVASKRGNANMVRLLLERGARIDARTKDGLTPLHCGARSGHEQVVEMLLDRGAPIL 335

  Fly   235 GQLPNGES---------------------------------ALHAAAMFGHMTVCKQLVAAGSDV 266
            .:..||.|                                 |||.||..||..|.|.||...::.
Zfish   336 SKTKNGLSPLHMATQGDHLNCVQLLIHHEVPVDDVTNDYLTALHVAAHCGHYKVAKVLVDKRANP 400

  Fly   267 LLKNHDGLTALQLAHQQKYTSICDYLQERIRTMVARSAKAMATSGVS 313
            ..|..:|.|.|.:|.::....:.:.|.:.     ..|.:|:..||::
Zfish   401 NAKALNGFTPLHIACKKNRIKVMELLLKH-----GASIQAVTESGLT 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3104	NP_001259969.1	Ank_2	<13..72	CDD:289560	18/58 (31%)
		ANK repeat	13..40	CDD:293786	7/26 (27%)
		ANK	37..162	CDD:238125	51/161 (32%)
		ANK repeat	42..73	CDD:293786	11/30 (37%)
		Ank_2	47..137	CDD:289560	40/120 (33%)
		ANK repeat	75..106	CDD:293786	16/30 (53%)
		ANK	103..228	CDD:238125	47/161 (29%)
		ANK repeat	108..137	CDD:293786	15/59 (25%)
		Ank_2	113..202	CDD:289560	33/125 (26%)
		ANK repeat	141..171	CDD:293786	11/29 (38%)
		ANK	169..292	CDD:238125	44/156 (28%)
		ANK repeat	174..204	CDD:293786	10/29 (34%)
		Ank_2	179..270	CDD:289560	35/124 (28%)
		ANK repeat	207..237	CDD:293786	13/30 (43%)
		ANK repeat	239..270	CDD:293786	14/63 (22%)
ank3b	XP_021335899.1	ANK	67..192	CDD:238125	45/115 (39%)
		ANK repeat	72..103	CDD:293786	7/26 (27%)
		ANK repeat	105..136	CDD:293786	11/30 (37%)
		ANK repeat	138..167	CDD:293786	16/28 (57%)
		Ank_4	201..262	CDD:316185	10/60 (17%)
		ANK repeat	204..239	CDD:293786	3/34 (9%)
		ANK	236..361	CDD:238125	38/124 (31%)
		ANK repeat	241..272	CDD:293786	11/30 (37%)
		ANK repeat	274..305	CDD:293786	10/30 (33%)
		ANK repeat	307..332	CDD:293786	11/24 (46%)
		ANK repeat	340..371	CDD:293786	3/30 (10%)
		ANK	368..493	CDD:238125	21/80 (26%)
		ANK repeat	376..404	CDD:293786	11/27 (41%)
		ANK repeat	406..437	CDD:293786	7/35 (20%)
		ANK repeat	439..470	CDD:293786	2/4 (50%)
		ANK	467..592	CDD:238125
		ANK repeat	472..503	CDD:293786
		ANK repeat	505..536	CDD:293786
		ANK repeat	538..567	CDD:293786
		ANK	567..691	CDD:238125
		ANK repeat	571..602	CDD:293786
		ANK repeat	604..635	CDD:293786
		ANK repeat	637..668	CDD:293786
		ANK	665..790	CDD:238125
		ANK repeat	670..701	CDD:293786
		ANK repeat	703..734	CDD:293786
		ANK repeat	736..767	CDD:293786
		ANK repeat	769..797	CDD:293786
		Ank_4	770..822	CDD:316185
		ZU5	1020..1122	CDD:128514
		Death_ank3	3451..3534	CDD:176781
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.000