DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3117 and F9

DIOPT Version :9

Sequence 1:	NP_608722.2	Gene:	CG3117 / 33484	FlyBaseID:	FBgn0031471	Length:	347	Species:	Drosophila melanogaster
Sequence 2:	NP_000124.1	Gene:	F9 / 2158	HGNCID:	3551	Length:	461	Species:	Homo sapiens

Alignment Length:	387	Identity:	100/387 - (25%)
Similarity:	154/387 - (39%)	Gaps:	116/387 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 SNLCVPRENCREEM-------PF--------FDFSSTIE-------C---SDEEVCCEKSNVIGM 66
            ||.|:...:|::::       ||        .|.:..|:       |   :|.:|.|..:....:
Human    99 SNPCLNGGSCKDDINSYECWCPFGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRL 163

  Fly    67 SK----------------SPPQHSVDTLLRTSYPNA-----------LDGSPQ-----------V 93
            ::                |..|.|..|...|.:|:.           ||...|           |
Human   164 AENQKSCEPAVPFPCGRVSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVV 228

  Fly    94 FGDQTKPNQFPWVTALFAKGSYLGGGSLITPGLVLTAAH-ILAGLSPNDIMVRAGEWDLSSSEKL 157
            .|:..||.||||...|..|.....|||::....::|||| :..|:.   |.|.|||.::..:|
Human   229 GGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVK---ITVVAGEHNIEETE-- 288

  Fly   158 NPPMDRQVIKIMEHEAFNYSSGAN----DLALLFLDSPFELRANIQTIRLPIPDKTFDRRICT-- 216
            :....|.||:|:.|.  ||::..|    |:|||.||.|..|.:.:..|  .|.||.:......
Human   289 HTEQKRNVIRIIPHH--NYNAAINKYNHDIALLELDEPLVLNSYVTPI--CIADKEYTNIFLKFG 349

  Fly   217 ---VAGWGM-----RSSTDVDIQTIQQKVDLPVVESSKCQRQLRLTKMGSNYQLPASLMCAGGEE 273
               |:|||.     ||:      .:.|.:.:|:|:.:.|   ||.||    :.:..::.|||..|
Human   350 SGYVSGWGRVFHKGRSA------LVLQYLRVPLVDRATC---LRSTK----FTIYNNMFCAGFHE 401

  Fly   274 -GRDVCSLFGGFALFCSLDDDPNRYE------QAGIVSFGVGCGQANVPTTFTHVSKFMEWI 328
             |||.|....|         .|:..|      ..||:|:|..|........:|.||:::.||
Human   402 GGRDSCQGDSG---------GPHVTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWI 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3117	NP_608722.2	Tryp_SPc	95..329	CDD:238113	78/256 (30%)
CG3117	NP_608722.2	Tryp_SPc	95..328	CDD:214473	76/254 (30%)
F9	NP_000124.1	GLA	28..92	CDD:214503
		EGF_CA	93..129	CDD:238011	6/29 (21%)
		FXa_inhibition	134..170	CDD:317114	5/35 (14%)
		Tryp_SPc	227..457	CDD:238113	79/259 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910