DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18557 and TMPRSS4

DIOPT Version :9

Sequence 1:	NP_608721.1	Gene:	CG18557 / 33483	FlyBaseID:	FBgn0031470	Length:	343	Species:	Drosophila melanogaster
Sequence 2:	XP_005271670.1	Gene:	TMPRSS4 / 56649	HGNCID:	11878	Length:	494	Species:	Homo sapiens

Alignment Length:	298	Identity:	78/298 - (26%)
Similarity:	123/298 - (41%)	Gaps:	81/298 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 LNCGKS--NPNGLGGTVEEVVDQAKPNEFPWTVALMQNLINFFGAGTLVTENIVITAAHLMLDKT 131
            |.||||  .|..:|      |::|..:.:||.|::..:..:..| |:::..:.|:||||.....|
Human   194 LACGKSLKTPRVVG------VEEASVDSWPWQVSIQYDKQHVCG-GSILDPHWVLTAAHCFRKHT 251

  Fly   132 INDFGIIGGAWDLKQLAGKTIQWRTATRIVSHP----------DFNKM-TGANNIALIVLETSFV 185
                    ..::.|..||       :.::.|.|          :||.| ...|:|||:.|:....
Human   252 --------DVFNWKVRAG-------SDKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLT 301

  Fly   186 MKPPIGPICWPTSGVSFDRE-----RCLVAGWGRPDFLAKNYSYKQKKI----DLPIVSRSDCES 241
            ....:.|||.|    .||.|     ...:.|||    ..|....|...|    .:.::..:.|.:
Human   302 FSGTVRPICLP----FFDEELTPATPLWIIGWG----FTKQNGGKMSDILLQASVQVIDSTRCNA 358

  Fly   242 LLRRTAFVQSFQLDPT--ILCAG-GERGRDACIGDGGSPLMCPIPGHPAIYE-----LVGIVNSG 298
                   ..::|.:.|  ::||| .|.|.|.|.||.|.|||         |:     :||||:.|
Human   359 -------DDAYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLM---------YQSDQWHVVGIVSWG 407

  Fly   299 FSCGLENVPALYTNISHMRPWI-----EKQLNDELNKP 331
            :.||..:.|.:||.:|....||     ::.:....|.|
Human   408 YGCGGPSTPGVYTKVSAYLNWIYNVWKDRTIQRSCNSP 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18557	NP_608721.1	Tryp_SPc	88..323	CDD:238113	68/267 (25%)
CG18557	NP_608721.1	Tryp_SPc	90..320	CDD:214473	66/257 (26%)
TMPRSS4	XP_005271670.1	LDLa	58..92	CDD:238060
		SRCR_2	108..197	CDD:295335	1/2 (50%)
		Tryp_SPc	204..429	CDD:214473	68/270 (25%)
		Tryp_SPc	205..432	CDD:238113	70/272 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910