DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18557 and PLG

DIOPT Version :9

Sequence 1:	NP_608721.1	Gene:	CG18557 / 33483	FlyBaseID:	FBgn0031470	Length:	343	Species:	Drosophila melanogaster
Sequence 2:	NP_000292.1	Gene:	PLG / 5340	HGNCID:	9071	Length:	810	Species:	Homo sapiens

Alignment Length:	343	Identity:	96/343 - (27%)
Similarity:	137/343 - (39%)	Gaps:	71/343 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 TETGAPCG------------LQMECVPQ-GLCKTSAWNQNA-ISWP-----SPCQRSESC----C 57
            |.||.||.            ...|..|: ||.|....|.:. :..|     :|.:..:.|    |
Human   496 TVTGTPCQDWAAQEPHRHSIFTPETNPRAGLEKNYCRNPDGDVGGPWCYTTNPRKLYDYCDVPQC 560

  Fly    58 HSSQKLVIGAP-LNCGKSNPNG-------LGGTVEEVVDQAKPNEFPWTVALMQNLINFFGAGTL 114
                    .|| .:|||.....       :||.|      |.|:.:||.|:|.......|..|||
Human   561 --------AAPSFDCGKPQVEPKKCPGRVVGGCV------AHPHSWPWQVSLRTRFGMHFCGGTL 611

  Fly   115 VTENIVITAAHLMLDKT--INDFGIIGGAWDLKQLAGKTIQWRTATRIVSHPDFNKMTGANNIAL 177
            ::...|:|||| .|:|:  .:.:.:|.||.....|. ..:|....:|:...|.      ..:|||
Human   612 ISPEWVLTAAH-CLEKSPRPSSYKVILGAHQEVNLE-PHVQEIEVSRLFLEPT------RKDIAL 668

  Fly   178 IVLETSFVMKPPIGPICWPTSG-VSFDRERCLVAGWGRPD--FLAKNYSYKQKKIDLPIVSRSDC 239
            :.|.:..|:...:.|.|.|:.. |..||..|.:.|||...  |.|.    ..|:..||::....|
Human   669 LKLSSPAVITDKVIPACLPSPNYVVADRTECFITGWGETQGTFGAG----LLKEAQLPVIENKVC 729

  Fly   240 ESLLRRTAFVQSFQLDPTILCAGG-ERGRDACIGDGGSPLMCPIPGHPAIYELVGIVNSGFSCGL 303
                .|..|:.. ::..|.||||. ..|.|:|.||.|.||:|   .....|.|.|:.:.|..|..
Human   730 ----NRYEFLNG-RVQSTELCAGHLAGGTDSCQGDSGGPLVC---FEKDKYILQGVTSWGLGCAR 786

  Fly   304 ENVPALYTNISHMRPWIE 321
            .|.|.:|..:|....|||
Human   787 PNKPGVYVRVSRFVTWIE 804

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18557	NP_608721.1	Tryp_SPc	88..323	CDD:238113	73/240 (30%)
CG18557	NP_608721.1	Tryp_SPc	90..320	CDD:214473	70/235 (30%)
PLG	NP_000292.1	PAN_AP_HGF	<38..97	CDD:238532
		KR	101..183	CDD:214527
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	126..145
		KR	183..263	CDD:214527
		KR	273..354	CDD:214527
		KR	375..456	CDD:214527
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	396..416
		KR	479..560	CDD:214527	14/63 (22%)
		Tryp_SPc	580..803	CDD:214473	73/248 (29%)
		Tryp_SPc	581..804	CDD:238113	74/248 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910