DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18557 and CFI

DIOPT Version :9

Sequence 1:	NP_608721.1	Gene:	CG18557 / 33483	FlyBaseID:	FBgn0031470	Length:	343	Species:	Drosophila melanogaster
Sequence 2:	NP_001362207.1	Gene:	CFI / 3426	HGNCID:	5394	Length:	601	Species:	Homo sapiens

Alignment Length:	242	Identity:	57/242 - (23%)
Similarity:	94/242 - (38%)	Gaps:	59/242 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 LNCGKSN------PNGLGGTVEEVVDQAKPNEFPWTVALMQNLINFFGAGTLVTENIVITAAHLM 127
            |:||..|      ...:||      .:|:..:.||.||: ::.......|..:....::||||.:
Human   333 LSCGVKNRMHIRRKRIVGG------KRAQLGDLPWQVAI-KDASGITCGGIYIGGCWILTAAHCL 390

  Fly   128 LDKTINDFGIIGGAW---------DLKQLAGKTIQWRTATRIVSHPDFNKMTGANNIALIVLETS 183
            .....:.:.|    |         |||::..:.:.     ||:.|.::|..|..|:||||.::..
Human   391 RASKTHRYQI----WTTVVDWIHPDLKRIVIEYVD-----RIIFHENYNAGTYQNDIALIEMKKD 446

  Fly   184 FVMK----PPIGPICWPTSGVSFD-RERCLVAGWGRPDFLAKNYSYKQKKIDLPIVSRSDCESLL 243
            ...|    |...|.|.|.|...|. .:.|:|:||||.....:.:|.:..::.|    .|:|....
Human   447 GNKKDCELPRSIPACVPWSPYLFQPNDTCIVSGWGREKDNERVFSLQWGEVKL----ISNCSKFY 507

  Fly   244 RRTAFVQSFQLDPTILCAGGERGRDAC-IGDGG------SPLMCPIP 283
            ....:.:..:      ||      |.| :...|      |.|..|.|
Human   508 GNRFYEKEME------CA------DCCSVAQAGVQWHDLSSLQPPPP 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18557	NP_608721.1	Tryp_SPc	88..323	CDD:238113	51/217 (24%)
CG18557	NP_608721.1	Tryp_SPc	90..320	CDD:214473	51/215 (24%)
CFI	NP_001362207.1	FIMAC	43..108	CDD:214493
		SR	114..215	CDD:214555
		LDLa	224..256	CDD:238060
		Ldl_recept_a	257..293	CDD:365841
		Tryp_SPc	348..>519	CDD:238113	44/196 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910