DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18557 and Tmprss6

DIOPT Version :9

Sequence 1:	NP_608721.1	Gene:	CG18557 / 33483	FlyBaseID:	FBgn0031470	Length:	343	Species:	Drosophila melanogaster
Sequence 2:	XP_006242057.1	Gene:	Tmprss6 / 315388	RGDID:	1307138	Length:	811	Species:	Rattus norvegicus

Alignment Length:	360	Identity:	92/360 - (25%)
Similarity:	141/360 - (39%)	Gaps:	69/360 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 IRCCFWTLTETGAPCGLQMECVPQGLCKTSAWNQNAISWPSPCQRSESCCHSSQKLVIGAPLNCG 72
            |:.|...|.|....|....:|.....|         ||.|..|.|...|.:.|.:......:.||
  Rat   477 IKDCPNGLDERNCVCRAMFQCQEDSTC---------ISLPRVCDRQPDCLNGSDEEQCQEGVPCG 532

  Fly    73 -------------KSNPN------------------GLGGTVEEVVDQA--KPNEFPWTVALMQN 104
                         |.||.                  ||.|....:|..|  ...|:||..:|...
  Rat   533 TFTFQCEDRSCVKKPNPECDGQADCRDGSDEEHCDCGLQGPSSRIVGGAMSSEGEWPWQASLQIR 597

  Fly   105 LINFFGAGTLVTENIVITAAHLMLDKTINDFGIIGGAWDLKQLAGKTIQ---WR-----TATRIV 161
            ..:..| |.|:.:..||||||...:.::....:    |.:  ..||..|   |.     ..:|:.
  Rat   598 GRHICG-GALIADRWVITAAHCFQEDSMASPRL----WTV--FLGKMRQNSRWPGEVSFKVSRLF 655

  Fly   162 SHPDFNKMTGANNIALIVLETSFVMKPPIGPICWPTSGVSFD-RERCLVAGWGRPDFLAKNYSYK 225
            .||...:.:...::||:.|:...|....:.|:|.|.....|: .:.|.:.|||.........|..
  Rat   656 LHPYHEEDSHDYDVALLQLDHPVVYSATVRPVCLPARSHFFEPGQHCWITGWGAQREGGPGSSTL 720

  Fly   226 QKKIDLPIVSRSDCESLLRRTAFVQSFQLDPTILCAGGERG-RDACIGDGGSPLMCPIPGHPAIY 289
            | |:|:.::.:..|....|       :|:.|.:||||..:| :|||.||.|.||:|..|.  ..:
  Rat   721 Q-KVDVQLIPQDLCNEAYR-------YQVTPRMLCAGYRKGKKDACQGDSGGPLVCKEPS--GRW 775

  Fly   290 ELVGIVNSGFSCGLENVPALYTNISHMRPWIEKQL 324
            .|.|:|:.|..||..|...:||.::.:..||::.|
  Rat   776 FLAGLVSWGLGCGRPNFFGVYTRVTRVVNWIQQVL 810

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18557	NP_608721.1	Tryp_SPc	88..323	CDD:238113	68/246 (28%)
CG18557	NP_608721.1	Tryp_SPc	90..320	CDD:214473	66/241 (27%)
Tmprss6	XP_006242057.1	SEA	88..185	CDD:279699
		LDLa	459..489	CDD:238060	4/11 (36%)
		LDLa	495..525	CDD:238060	9/38 (24%)
		Ldl_recept_a	529..566	CDD:278486	5/36 (14%)
		Tryp_SPc	576..806	CDD:214473	67/246 (27%)
		Tryp_SPc	577..809	CDD:238113	69/248 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910