DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18557 and TMPRSS12

DIOPT Version :9

Sequence 1:	NP_608721.1	Gene:	CG18557 / 33483	FlyBaseID:	FBgn0031470	Length:	343	Species:	Drosophila melanogaster
Sequence 2:	NP_872365.2	Gene:	TMPRSS12 / 283471	HGNCID:	28779	Length:	348	Species:	Homo sapiens

Alignment Length:	283	Identity:	83/283 - (29%)
Similarity:	120/283 - (42%)	Gaps:	65/283 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 APLNCGKSNPNGLGGTVEEVVDQAKPNEFPWTVALM----QNLINFFGAGTLVTENIVITAAH-- 125
            |||.........:|||      :|:...:||.|:|.    :.|::..| ||||.|..|:||||
Human    67 APLKDVLQGSRIIGGT------EAQAGAWPWVVSLQIKYGRVLVHVCG-GTLVRERWVLTAAHCT 124

  Fly   126 ------LMLDKTINDFGIIGGAWDLKQLAGKTIQWRTATRIVSHPDFNKMTGANNIALIVLETSF 184
                  ||....|....|.|.....|::..|.        |:.||:|...:..|:|||..|:.:.
Human   125 KDASDPLMWTAVIGTNNIHGRYPHTKKIKIKA--------IIIHPNFILESYVNDIALFHLKKAV 181

  Fly   185 VMKPPIGPICWPTSGVSFD-------RERCLVAGWGRPDFLAK---NYSYKQKKIDLPIVSRSDC 239
            .....|.|||.|     ||       ..:|.::||||    .|   |.:...:..::..:||..|
Human   182 RYNDYIQPICLP-----FDVFQILDGNTKCFISGWGR----TKEEGNATNILQDAEVHYISREMC 237

  Fly   240 ES------LLRRTAFVQSFQLDPTILCAGGERGR-DACIGDGGSPLMCPIPGHPAIYELVGIVNS 297
            .|      ::..|:|           |||.|.|. |.|.||.|.||||.:|.:...: ::||.:.
Human   238 NSERSYGGIIPNTSF-----------CAGDEDGAFDTCRGDSGGPLMCYLPEYKRFF-VMGITSY 290

  Fly   298 GFSCGLENVPALYTNISHMRPWI 320
            |..||....|.:|...|..:.|:
Human   291 GHGCGRRGFPGVYIGPSFYQKWL 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18557	NP_608721.1	Tryp_SPc	88..323	CDD:238113	77/262 (29%)
CG18557	NP_608721.1	Tryp_SPc	90..320	CDD:214473	76/258 (29%)
TMPRSS12	NP_872365.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	24..63
TMPRSS12	NP_872365.2	Tryp_SPc	78..316	CDD:238113	80/272 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910