DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18557 and F10

DIOPT Version :9

Sequence 1:	NP_608721.1	Gene:	CG18557 / 33483	FlyBaseID:	FBgn0031470	Length:	343	Species:	Drosophila melanogaster
Sequence 2:	NP_000495.1	Gene:	F10 / 2159	HGNCID:	3528	Length:	488	Species:	Homo sapiens

Alignment Length:	349	Identity:	78/349 - (22%)
Similarity:	133/349 - (38%)	Gaps:	74/349 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 WTLTETGAPCGLQMECVPQGLCKTSAWNQNAISWPSPC--------QRSESCCHSSQKLVIGAP- 68
            :||.:.|      ..|:|.|              |.||        :||.:...||..   .||
Human   155 YTLADNG------KACIPTG--------------PYPCGKQTLERRKRSVAQATSSSG---EAPD 196

  Fly    69 ---------------------LNCGKSNPNGLGGTVEEVV--DQAKPNEFPWTVALMQNLINFFG 110
                                 |:..::.|......:..:|  .:.|..|.||...|:......|.
Human   197 SITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFC 261

  Fly   111 AGTLVTENIVITAAHLMLDKTINDFGIIGGAWDLKQLAGKTIQWRTATRIVSHPDFNKMTGANNI 175
            .||:::|..::||||.:..  ...|.:..|..:.:|..|......... ::.|..|.|.|...:|
Human   262 GGTILSEFYILTAAHCLYQ--AKRFKVRVGDRNTEQEEGGEAVHEVEV-VIKHNRFTKETYDFDI 323

  Fly   176 ALIVLETSFVMKPPIGPICWP----TSGVSFDRERCLVAGWGRPDFLAKNYSYKQKKIDLPIVSR 236
            |::.|:|....:..:.|.|.|    .......::..:|:|:||.....:. |.:.|.:::|.|.|
Human   324 AVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQ-STRLKMLEVPYVDR 387

  Fly   237 SDCESLLRRTAFVQSFQLDPTILCAGGE-RGRDACIGDGGSPLMCPIPGHPAIYELVGIVNSGFS 300
            :.|:       ...||.:...:.|||.: :..|||.||.|.|   .:......|.:.|||:.|..
Human   388 NSCK-------LSSSFIITQNMFCAGYDTKQEDACQGDSGGP---HVTRFKDTYFVTGIVSWGEG 442

  Fly   301 CGLENVPALYTNISHMRPWIEKQL 324
            |..:....:||.::....||::.:
Human   443 CARKGKYGIYTKVTAFLKWIDRSM 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18557	NP_608721.1	Tryp_SPc	88..323	CDD:238113	60/239 (25%)
CG18557	NP_608721.1	Tryp_SPc	90..320	CDD:214473	58/234 (25%)
F10	NP_000495.1	GLA	25..85	CDD:214503
		EGF_CA	86..122	CDD:238011
		FXa_inhibition	129..164	CDD:317114	3/14 (21%)
		O-glycosylated at one site	183..203		5/22 (23%)
		Tryp_SPc	235..464	CDD:238113	61/242 (25%)
		O-glycosylated at one site	476..485
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910