DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18557 and F9

DIOPT Version :9

Sequence 1:	NP_608721.1	Gene:	CG18557 / 33483	FlyBaseID:	FBgn0031470	Length:	343	Species:	Drosophila melanogaster
Sequence 2:	NP_000124.1	Gene:	F9 / 2158	HGNCID:	3551	Length:	461	Species:	Homo sapiens

Alignment Length:	366	Identity:	91/366 - (24%)
Similarity:	147/366 - (40%)	Gaps:	78/366 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 CFWTLTETGAPCGLQMEC-VPQG----LCKTSAWNQNAISWPSPCQRSESCCHSSQKLVIGAPLN 70
            |:......|..|.|.:.| :..|    .||.||.|:...|    |........:.:......|..
Human   117 CWCPFGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCS----CTEGYRLAENQKSCEPAVPFP 177

  Fly    71 CGK----------------SNPNGLGGTVEEVV--------------------DQAKPNEFPWTV 99
            ||:                .:.:.:..|..|.:                    :.|||.:|||.|
Human   178 CGRVSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPWQV 242

  Fly   100 ALMQNLINFFGAGTLVTENIVITAAHLMLDKTINDFGIIGGAWDLKQLAGKTIQWRTATRIVSHP 164
            .| ...::.|..|::|.|..::||||.:  :|.....::.|..:::: ...|.|.|...||:.|.
Human   243 VL-NGKVDAFCGGSIVNEKWIVTAAHCV--ETGVKITVVAGEHNIEE-TEHTEQKRNVIRIIPHH 303

  Fly   165 DFNKMTGANN--IALIVLETSFVMKPPIGPICWPTSGVSFDRERC---------LVAGWGRPDFL 218
            ::|......|  |||:.|:...|:...:.|||      ..|:|..         .|:||||. |.
Human   304 NYNAAINKYNHDIALLELDEPLVLNSYVTPIC------IADKEYTNIFLKFGSGYVSGWGRV-FH 361

  Fly   219 AKNYSYKQKKIDLPIVSRSDCESLLRRTAFVQSFQLDPTILCAG-GERGRDACIGDGGSPLMCPI 282
            ....:...:.:.:|:|.|:.|   ||.|    .|.:...:.||| .|.|||:|.||.|.|.:..:
Human   362 KGRSALVLQYLRVPLVDRATC---LRST----KFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEV 419

  Fly   283 PGHPAIYELVGIVNSGFSCGLENVPALYTNISHMRPWIEKQ 323
            .|...   |.||::.|..|.::....:||.:|....||:::
Human   420 EGTSF---LTGIISWGEECAMKGKYGIYTKVSRYVNWIKEK 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18557	NP_608721.1	Tryp_SPc	88..323	CDD:238113	73/246 (30%)
CG18557	NP_608721.1	Tryp_SPc	90..320	CDD:214473	71/241 (29%)
F9	NP_000124.1	GLA	28..92	CDD:214503
		EGF_CA	93..129	CDD:238011	2/11 (18%)
		FXa_inhibition	134..170	CDD:317114	9/39 (23%)
		Tryp_SPc	227..457	CDD:238113	73/250 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910