DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18557 and C1s

DIOPT Version :9

Sequence 1:	NP_608721.1	Gene:	CG18557 / 33483	FlyBaseID:	FBgn0031470	Length:	343	Species:	Drosophila melanogaster
Sequence 2:	NP_620255.2	Gene:	C1s / 192262	RGDID:	619983	Length:	694	Species:	Rattus norvegicus

Alignment Length:	433	Identity:	100/433 - (23%)
Similarity:	150/433 - (34%)	Gaps:	153/433 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 WTLTETGAPCGLQMECVPQGLCKTSAW--------------------------NQNAISWPSPCQ 51
            |.|...|.|    :.| |:.:...|.|                          |..:.|:.|.||
  Rat   289 WKLRYHGDP----IPC-PKEISANSIWEPEKAKYVFKDVVKITCVDGFEVVEGNVGSTSFYSTCQ 348

  Fly    52 RSESCCHSSQKLVIGAPLNCGKSNP--NG-------------LGGTVEE---------------- 85
            .:....:|..:.   .|::||...|  ||             :..|.||
  Rat   349 SNGQWSNSRLEC---QPVDCGVPEPIENGKVEDPEDTVFGSVIHYTCEEPYYYMEQEEGGEYHCA 410

  Fly    86 -----VVDQ------------------------------AKPNEFPWTVALMQNLINFF----GA 111
                 |.||                              .|...|||.|        :|    |.
  Rat   411 ANGSWVNDQLGVELPKCIPVCGVPTEPFKVQQRIFGGYSTKIQSFPWQV--------YFESPRGG 467

  Fly   112 GTLVTENIVITAAHLMLDKTINDFGIIGGAWDLKQLAGKTI----QWRTATRIVS-----HP--- 164
            |.|:.|..|:||||           ::.|..|.....|.|:    :.|.|.|:::     ||
  Rat   468 GALIDEYWVLTAAH-----------VVEGNSDPVMYVGSTLLKIERLRNAQRLITERVIIHPSWK 521

  Fly   165 ---DFNKMTG-ANNIALIVLETSFVMKPPIGPICWPTSGVSF---DRERCLVAGWGRPDFLAKNY 222
               |.|..|. .|:|||:.|:....|.|.:.|||.|.:...:   :.:..|::||||.:......
  Rat   522 QEDDLNTRTNFDNDIALVQLKDPVKMGPTVAPICLPETSSDYNPSEGDLGLISGWGRTENRTNVI 586

  Fly   223 SYKQKKIDLPIVSRSDCESLLRRTAFVQS--FQLDPTILCAGGERGRDACIGDGGSPLMCPIPG- 284
            ..:..|  |||.|...|:.:.......:|  :.....::|| ||:|.|:|.||.|.....|:|.
  Rat   587 QLRGAK--LPITSLEKCQQVKVENPKARSNDYVFTDNMICA-GEKGVDSCEGDSGGAFALPVPNV 648

  Fly   285 -HPAIYELVGIVNSGFSCGLENVPALYTNISHMRPWIEKQLND 326
             .|..| :.|:|:.|..||...:   ||.:.:...||.|.:.:
  Rat   649 KDPKFY-VAGLVSWGKKCGTYGI---YTKVKNYVDWILKTMQE 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18557	NP_608721.1	Tryp_SPc	88..323	CDD:238113	75/291 (26%)
CG18557	NP_608721.1	Tryp_SPc	90..320	CDD:214473	71/256 (28%)
C1s	NP_620255.2	CUB	24..135	CDD:238001
		FXa_inhibition	149..177	CDD:405372
		CUB	181..293	CDD:395345	2/3 (67%)
		CCP	300..361	CDD:153056	10/64 (16%)
		CCP	365..428	CDD:153056	11/62 (18%)
		Tryp_SPc	443..681	CDD:214473	71/263 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910