DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18557 and tmprss6

DIOPT Version :9

Sequence 1:	NP_608721.1	Gene:	CG18557 / 33483	FlyBaseID:	FBgn0031470	Length:	343	Species:	Drosophila melanogaster
Sequence 2:	XP_004913946.2	Gene:	tmprss6 / 100489045	XenbaseID:	XB-GENE-1011573	Length:	806	Species:	Xenopus tropicalis

Alignment Length:	385	Identity:	98/385 - (25%)
Similarity:	151/385 - (39%)	Gaps:	119/385 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 IRCCFWTLTETGAPCGLQMECVPQGLCKTSAWNQNAISWPSPCQRSESCCHSSQKLVIGAPLN-- 70
            ::.|...|.|....|..|..|.....|         ||..|.|...:.|.:.:.:.:.....|
Frog   466 VKDCPNELDERNCVCPAQYHCPGAESC---------ISITSVCDGKKDCANGTDEELCNQGANFP 521

  Fly    71 ---CGKSN----------------------PNG-----------------LGGTVEEVVDQAKPN 93
               ||..|                      |:|                 :|||      ||:..
Frog   522 TAACGAFNYKCADGSCVQKPNAECDSIADCPDGSDENNCGCGIQAVGIRLVGGT------QAQEG 580

  Fly    94 EFPWTVALMQNLINFFGAGTLVTENIVITAAHLMLDKTINDFGIIGGAWDL------------KQ 146
            |:||..:|.....:..| ||||.:..::||||....::.....:    |.:            |:
Frog   581 EWPWQASLQVRGEHICG-GTLVADQWILTAAHCFTPESYASPEV----WTVYLGKVRLSRSTQKE 640

  Fly   147 LAGKTIQWRTATRIVSHPDFNKMTGANNIALIVLE-----TSFVMKPPIGPICWPTSGVSFDR-E 205
            ||.|.|      |:|.||.:::.:...::||::|:     ||    |.:.|||.|:|...|.. .
Frog   641 LAFKVI------RLVIHPFYDEDSHDYDVALVLLDHLVPLTS----PHVQPICLPSSTHHFPTGS 695

  Fly   206 RCLVAGWGRPDFLAKNYSYKQ--------KKIDLPIVSRSDCESLLRRTAFVQSFQLDPTILCAG 262
            .|.|.|||         |.|:        :|:|:.:|::..|..|.|       :|:.|.:||||
Frog   696 SCWVTGWG---------SVKENGPTSDVLQKVDIQLVAQDICTELYR-------YQISPRMLCAG 744

  Fly   263 GERG-RDACIGDGGSPLMCPIPGHPAIYELVGIVNSGFSCGLENVPALYTNISHMRPWIE 321
            ...| :|||.||.||||:|....  ..:...|:|:.|..||:.....:|:.|:.:..|||
Frog   745 YRDGSKDACQGDSGSPLVCKTAS--GRWFQAGLVSWGAGCGIPRYFGVYSRITRLVQWIE 802

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18557	NP_608721.1	Tryp_SPc	88..323	CDD:238113	77/261 (30%)
CG18557	NP_608721.1	Tryp_SPc	90..320	CDD:214473	73/256 (29%)
tmprss6	XP_004913946.2	SEA	77..176	CDD:396113
		CUB	235..303	CDD:412131
		LDLa	448..478	CDD:238060	3/11 (27%)
		LDLa	480..514	CDD:238060	9/42 (21%)
		LDLa	525..560	CDD:238060	5/34 (15%)
		Tryp_SPc	572..804	CDD:238113	80/270 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910