DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2975 and B3GLCT

DIOPT Version :9

Sequence 1:	NP_608719.1	Gene:	CG2975 / 33481	FlyBaseID:	FBgn0031468	Length:	385	Species:	Drosophila melanogaster
Sequence 2:	NP_919299.3	Gene:	B3GLCT / 145173	HGNCID:	20207	Length:	498	Species:	Homo sapiens

Alignment Length:	313	Identity:	77/313 - (24%)
Similarity:	120/313 - (38%)	Gaps:	67/313 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 WGILLSELMKRTRWQNHADRLKEES--SPFPSSQR--------SRNLRTPPTIAPSTTNPPPDIL 76
            |.:.:..:.|.|:      |||.||  |.|....:        .:....|.|..|.......|..
Human   190 WALSIPLVNKLTK------RLKSESLKSDFTIDLKHEIALYIWDKGGGPPLTPVPEFCTNDVDFY 248

  Fly    77 AARLFNETRVLC-----------MVLTSPKTHHTRAIHIKRTWGRRCNKLIFMSTKADKELGSVA 130
            .|..|:....||           .|.|..|.|..|...:|:||..:.:.:.:.|...:..:.:|.
Human   249 CATTFHSFLPLCRKPVKKKDIFVAVKTCKKFHGDRIPIVKQTWESQASLIEYYSDYTENSIPTVD 313

  Fly   131 L---NVREGYSNLWPKTRAALQYVYKHHFQKYDWFLKADDDTYFIMENLRAFLHAHNFREPVYFG 192
            |   |...|:..   ||.|.|:........|..|.:..||||...:..|:..|..::..|||:.|
Human   314 LGIPNTDRGHCG---KTFAILERFLNRSQDKTAWLVIVDDDTLISISRLQHLLSCYDSGEPVFLG 375

  Fly   193 NKFRQHVKEG---YMSGGAGYVLSKMALHRLIKLGFSNSSIC-TNRNYGYEDVELGRCLAGVGVV 253
            .::...:..|   |::||.|.|.|:.|:.||:      :|.| ...|...:|:.||.|.:|:|:.
Human   376 ERYGYGLGTGGYSYITGGGGMVFSREAVRRLL------ASKCRCYSNDAPDDMVLGMCFSGLGIP 434

  Fly   254 GGDSRDEQGLSRFIPFSPLHWYPQPPDWYQPLLYYTSPDNSSDCCSNTAISFH 306
                         :..|||....:|.|:.:..|.:..|           ||||
Human   435 -------------VTHSPLFHQARPVDYPKDYLSHQVP-----------ISFH 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2975	NP_608719.1	Galactosyl_T	90..>214	CDD:304462	35/129 (27%)
B3GLCT	NP_919299.3	Galactosyl_T	264..467	CDD:304462	59/233 (25%)
B3GLCT	NP_919299.3	Prevents secretion from ER	495..498
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2246
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810