Protein Alignment Duox and FRE4

DIOPT Version :9

• Sequence 1: NP_001259968.1
• Gene: Duox / 33477
• FlyBaseID: FBgn0283531
• Length: 1537
• Species: Drosophila melanogaster
• Sequence 2: NP_014458.1
• Gene: FRE4 / 855797
• SGDID: S000005343
• Length: 719
• Species: Saccharomyces cerevisiae
• Alignment Length: 585
• Identity: 117/585 - (20%)
• Similarity: 216/585 - (36%)
• Gaps: 155/585 - (26%)

  Fly  1021 TFLEENRQNIFYL---------------FLFYVVTIVLFVERFIHYS-----FMAEHTDLRHIMG 1065
            |..|::.:...||               .|.|::...:|:.....|.     |.|...::.|.:.
Yeast   206 TLYEKHAEPFSYLKVITGYLPTRFETLVILGYLILHTIFMAYKYQYDPYHIIFAAHRAEVAHFVA 270

  Fly  1066 VGIAITRGSAASLSFCY-SLLLLTMSRN----LITKLKEFPIQQYIPLDSHIQFHKIAACTALFF 1125
            ....|       |||.: .|::|...||    ||:.||.         .|.|.|||.........
Yeast   271 YRSGI-------LSFAHLPLIVLFAGRNNFLQLISGLKH---------TSFIVFHKWLGRMMFLD 319

  Fly  1126 SVLHTVGHIVNFY-HVSTQSHENLRCLTREVHFASDYKPDITFWLFQ-TVTGTTGVMLFIIMCII 1188
            :::|..| ..|:| :....:...||                .:|.|. ..|...|:::|
Yeast   320 AIIHAAG-FTNYYLYYKKWNTVRLR----------------VYWKFGIATTCLAGMLIF------ 361

  Fly  1189 FVFAHPTIRKKAYNFFWNMHTLYIGLYLLSLIHGLARLTGPPRFWMFFLGPGIVYTLDKIVSL-R 1252
              |:....|:..|..|..:|.::..|:|.:....:...:|..  |::  ....::.:|:||.: |
Yeast   362 --FSIAAFRRHYYETFMALHIVFAALFLYTCWEHVTNFSGIE--WIY--AAIAIWGVDRIVRITR 420

  Fly  1253 TKYMALDVIDTDLLPSDVIKIKFYRPPNL-KYLSGQWVRLSCTAFRP---HEMHSFT-LTSAPHE 1312
            ...:.....|..|:.||::::...:|... |...||:|.:|  ..||   .:.|.|| :.|..::
Yeast   421 IALLGFPKADLQLVGSDLVRVTVKKPKKFWKAKPGQYVFVS--FLRPLCFWQSHPFTVMDSCVND 483

  Fly  1313 NFLSCHIKAQGPWTWKLRNYFDPCNYNPEDQPKIRIEGPFGGGNQDWYKFEVAVMVGGGIGVTPY 1377
            ..|...:||:...|..:||:.:  ....:...::.||||: |.....::|:..:::.||.|:.
Yeast   484 RELVIVLKAKKGVTKLVRNFVE--RKGGKASMRLAIEGPY-GSKSTAHRFDNVLLLAGGSGLP-- 543

  Fly  1378 ASILNDLVFGTSTNRYSGVACKKVYFLWICPSHKHFEWFIDVLRDVE-----KKDVTNVLEIHIF 1437
            ..|.:.|..|.:|                ..|.|:|...:..:|.::     ||::..:..:::.
Yeast   544 GPISHALELGKTT----------------AASGKNFVQLVIAVRGLDMLNACKKELMALKGLNVQ 592

  Fly  1438 ITQFFHKFDLRTTMLYICENHFQR------------------------------LSKTSIFTGLK 1472
            :..:..|.:|.:.. .|..|..:.                              |:.|||.....
Yeast   593 VHIYNSKQELASAE-KISSNEVKNGETTAEKAPSSLSNSEKAPSESENTELPLSLNDTSISDLEF 656

  Fly  1473 AVNHFGRPDMSSFLKFVQKKHSYVSKIGVFSCGPRPL---------TKSVMSACDEVNKTRKLPY 1528
            |..|.|||::...|   .:..::...:.|..||| |:         .|:|:.     |.:|.:.|
Yeast   657 ATFHVGRPNVEEIL---NESVNHSGSLAVVCCGP-PIFVDTARNQTAKAVIR-----NPSRMIEY 712

  Fly  1529  1528
            Yeast   713  712

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Duox	NP_001259968.1	An_peroxidase	70..580	CDD:281139
		dual_peroxidase_like	72..625	CDD:188652
		EFh	827..882	CDD:238008
		EFh	860..921	CDD:238008
		EF-hand_7	860..920	CDD:290234
		EFh	895..966	CDD:238008
		EF-hand_7	899..965	CDD:290234
		Ferric_reduct	1084..1217	CDD:280043	30/138 (22%)
		NOX_Duox_like_FAD_NADP	1265..1536	CDD:99783	64/313 (20%)
FRE4	NP_014458.1	Ferric_reduct	276..389	CDD:396386	34/146 (23%)
		NOX_Duox_like_FAD_NADP	428..596	CDD:99783	41/190 (22%)
		NAD_binding_6	530..699	CDD:369657	33/191 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810