Protein Alignment Duox and AIM14

DIOPT Version :9

• Sequence 1: NP_001259968.1
• Gene: Duox / 33477
• FlyBaseID: FBgn0283531
• Length: 1537
• Species: Drosophila melanogaster
• Sequence 2: NP_011355.1
• Gene: AIM14 / 852716
• SGDID: S000003128
• Length: 570
• Species: Saccharomyces cerevisiae
• Alignment Length: 562
• Identity: 107/562 - (19%)
• Similarity: 200/562 - (35%)
• Gaps: 156/562 - (27%)

  Fly  1035 LFYVVTIVLFVERFIHYSFMAEHTDLRHIMGVGIAITRGSAASLSFCYSLLLLTMSRNLITKLKE 1099
            ||:.|.|..    :.|||...:.|         :.:.|....|.:.....|.||:..|...: |.
Yeast    76 LFFAVLIPF----YYHYSLTTQST---------VYLKRLGRLSYALIPLNLFLTLRPNWFLR-KN 126

  Fly  1100 FPIQQYIPLDSHIQFHKIAACTALFFSVLHTVGHIVNFYHVSTQSHENL----RCLTREVHFASD 1160
            .....:||      |||..:.......:||.:     |:.:.....:|:    :.:.:..:||
Yeast   127 CTYTDFIP------FHKWFSRIITVIGLLHGI-----FFIIKWAIDDNVSLKQKLILKTFNFA-- 178

  Fly  1161 YKPDITFWLFQTVTGTTGVMLFIIMCIIFVFAHPTIRKKAYNFFWNMHTLY-IGLYLLSLIHGLA 1224
                             |.::.|::..:.:.:...:|:..|..|:.:|.|. :...||:.||...
Yeast   179 -----------------GFIISILVLFLLICSIGPMRRYNYRLFYIVHNLVNVAFILLTPIHSRP 226

  Fly  1225 RLTGPPRFWMFFLGPGIVYTLDKIVSLRT--------KYMALDVIDTDL---------LPSDVIK 1272
            .:..|  |.:.......::.:::||..::        .|...:::...|         .|...|:
Yeast   227 GVKFP--FLLLNCTLLFIHIINRIVFAKSLMILNKNANYSKTNLVHVRLPRAILPDYFEPGSHIR 289

  Fly  1273 IKFYRPPNLKYLSGQWVRLSCTAFRPHEMHSFTLTSAPHENFLSCHIKAQGPWTWKLRNYFDPCN 1337
            |..||..|..|    |:..|         |.:|:.|...:|.:...||...  |.:..:..:...
Yeast   290 ISPYRRINPLY----WLLPS---------HPYTIASLAEDNSIDLIIKETS--TAEPGSQIESLR 339

  Fly  1338 YNPE----DQ-----------PKIRIEGPFGGGNQDWYKFEVAVMVGGGIGVTPYASILNDLVFG 1387
            .||:    ||           |.:..|....|.|       :|::.||. |:: :|..|....|.
Yeast   340 SNPKSFHLDQEKTYTLINSYPPSVPEECYSQGTN-------IAIICGGS-GIS-FALPLFRHFFN 395

  Fly  1388 TSTNRYSGVACKKVYFLWICPSHKHFEWFIDVLR----DVEKKDVTNVLEIHIFITQFF---HKF 1445
            ....:|       :..:|:...:..:|..:|.|:    ..||| ::|...|.:||:..:   .:.
Yeast   396 KENVKY-------LKMIWLIKDYSEYELVLDYLKTNGLTFEKK-LSNNKRISVFISGEYTAETRL 452

  Fly  1446 DLRTTMLYICENHFQRLS--------KTSIFTGLKAVNHFGRPDMS--------SFLKFVQKKHS 1494
            |..||.:....:.::..|        ..|.|....|.::...|:.|        |.:: |:.|||
Yeast   453 DEITTNIDDENSEYEMGSFNNEDEDLSISNFNSENADSNDNTPETSHSPTKENGSMIE-VKSKHS 516

  Fly  1495 YV-----------------SKIGVFSCGPRPLTKSVMSACDE 1519
            :.                 ::..:|||||..|.:.....|::
Yeast   517 FTLSNELKSFNNESAQVNQNETWLFSCGPPSLLQLSKKYCND 558

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Duox	NP_001259968.1	An_peroxidase	70..580	CDD:281139
		dual_peroxidase_like	72..625	CDD:188652
		EFh	827..882	CDD:238008
		EFh	860..921	CDD:238008
		EF-hand_7	860..920	CDD:290234
		EFh	895..966	CDD:238008
		EF-hand_7	899..965	CDD:290234
		Ferric_reduct	1084..1217	CDD:280043	23/137 (17%)
		NOX_Duox_like_FAD_NADP	1265..1536	CDD:99783	65/319 (20%)
AIM14	NP_011355.1	Ferric_reduct	104..219	CDD:396386	24/145 (17%)
		FAD_binding_8	253..365	CDD:285293	23/126 (18%)
		NAD_binding_6	372..557	CDD:369657	40/202 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810