Protein Alignment Duox and FRE1

DIOPT Version :10

• Sequence 1: NP_608715.2
• Gene: Duox / 33477
• FlyBaseID: FBgn0283531
• Length: 1537
• Species: Drosophila melanogaster
• Sequence 2: NP_013315.1
• Gene: FRE1 / 850911
• SGDID: S000004204
• Length: 686
• Species: Saccharomyces cerevisiae
• Alignment Length: 633
• Identity: 117/633 - (18%)
• Similarity: 209/633 - (33%)
• Gaps: 237/633 - (37%)

  Fly  1012 LLAKWDAYITFLEEN---RQNI------------FYLFLFYVVTIVLFVERFIHYSFMA------ 1055
            |:|...||..:.|||   ..|:            |::.:....||:..::|....:.||
Yeast   121 LMANETAYHYYYEENYGIHLNLMRSQWCAWGLVFFWVAVLTAATILNILKRVFGKNIMANSVKKS 185

  Fly  1056 --------EHTDLRHIMGVGIAI---TRG-----------SAASLSFCYSLLL------------ 1086
                    ::.:....:...:..   |||           :..||||.:::.|
Yeast   186 LIYPSVYKDYNERTFYLWKRLPFNFTTRGKGLVVLIFVILTILSLSFGHNIKLPHPYDRPRWRRS 250

  Fly  1087 --LTMSRNLITKLKEFPI--------QQYIPLD----SHIQF-HKIAACTALFFSVLHTVGHIVN 1136
              ....|..:..:..||:        ..:||:.    |...| ||.:|......:|:|::
Yeast   251 MAFVSRRADLMAIALFPVVYLFGIRNNPFIPITGLSFSTFNFYHKWSAYVCFMLAVVHSI----- 310

  Fly  1137 FYHVSTQSHEN---LRCLTREVHFASDYKPDITFWLFQTVTGTTGVMLFIIMCIIFVFAHPTIRK 1198
               |.|.|...   .:.|.|:.:|.         |         |::..|:|.||...:....|.
Yeast   311 ---VMTASGVKRGVFQSLVRKFYFR---------W---------GIVATILMSIIIFQSEKVFRN 354

  Fly  1199 KAYNFFWNMHTLYIGLYLLSLIHGLARLTGPPRFWMFFLGPGIVYTLDKIV-------------- 1249
            :.|..|..:|.....::::::.:....|.     ||     |.::::..|:
Yeast   355 RGYEIFLLIHKAMNIMFIIAMYYHCHTLG-----WM-----GWIWSMAGILCFDRFCRIVRIIMN 409

  Fly  1250 -SLRTKYMALDVIDTDLLPSDVIKIKFYRPPNLKYLSGQWVRL-----SCTAFRPHEMHSFTLTS 1308
             .|:|..::    .||  .|:||||...:|...||..|.:..:     ....|...:.|.||:.|
Yeast   410 GGLKTATLS----TTD--DSNVIKISVKKPKFFKYQVGAFAYMYFLSPKSAWFYSFQSHPFTVLS 468

  Fly  1309 APHE-----NFLSCHIKAQGPWTWKL-------RNYFDPCNYNPEDQPKIRIEGPFGGGNQDWYK 1361
            ..|.     :.|:.::||....|..|       .|:...|        ||.:|||:
Yeast   469 ERHRDPNNPDQLTMYVKANKGITRVLLSKVLSAPNHTVDC--------KIFLEGPY--------- 516

  Fly  1362 FEVAVMVGGGIGVTPYASILNDLVFGTSTNRYSGVACKKVY------------------FLWICP 1408
                     |:.|...|.:..:|| |.:    :|:....:|                  |.||..
Yeast   517 ---------GVTVPHIAKLKRNLV-GVA----AGLGVAAIYPHFVECLRLPSTDQLQHKFYWIVN 567

  Fly  1409 SHKHFEWFIDVLRDVEKKDVTNVLEIHIFIT--------------QFFHKFDLRTTMLYICENHF 1459
            ...|.:||.:.|:.:::|.    .|:.:..|              .|..|.:...|:
Yeast   568 DLSHLKWFENELQWLKEKS----CEVSVIYTGSSVEDTNSDESTKGFDDKEESEITV-------- 620

  Fly  1460 QRLSKTSIFTGLKAVNHFGRPDMSSFLKF-VQKKHSYVSKIGVFSCGP 1506
            :.|:|              |||:...::. ::......:.|..:||||
Yeast   621 ECLNK--------------RPDLKELVRSEIKLSELENNNITFYSCGP 654

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Duox	NP_608715.2	dual_peroxidase_like	72..625	CDD:188652
		PTZ00184	807..965	CDD:185504
		EFh	860..921	CDD:238008
		PLN02844	<1081..>1393	CDD:215453	71/373 (19%)
		NOX_Duox_like_FAD_NADP	1265..1536	CDD:99783	58/292 (20%)
FRE1	NP_013315.1	CFEM	26..84	CDD:399033
		Ferric_reduct	260..375	CDD:426438	27/140 (19%)
		NOX_Duox_like_FAD_NADP	414..684	CDD:99783	61/304 (20%)