DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Duox and FRE6

DIOPT Version :9

Sequence 1:	NP_001259968.1	Gene:	Duox / 33477	FlyBaseID:	FBgn0283531	Length:	1537	Species:	Drosophila melanogaster
Sequence 2:	NP_013049.1	Gene:	FRE6 / 850675	SGDID:	S000003974	Length:	712	Species:	Saccharomyces cerevisiae

Alignment Length:	735	Identity:	146/735 - (19%)
Similarity:	254/735 - (34%)	Gaps:	249/735 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   931 SLGDDQVT-ELIDGMFQDVGLEHKNHLTYQDFKLMMKEYKGDFVAIGLDCKGAKQNFLDTSTNVA 994
            |||:.:.| ..:|..|.::.||.    .|............|:.:|         ..|.||..|.
Yeast    95 SLGNVRKTCSFVDKKFSNISLEQ----YYSSLNNASSHALEDYGSI---------ESLSTSIRVD 146

  Fly   995 RMT-----------SFNIEPMQDKPRHWLLAKWDAYITFLEENRQNIFYLFLFYVVTI------- 1041
            |.|           ::|::         :.:.:.||:|         :|..:..::.:
Yeast   147 RETRSRWIRAFHAHAYNLD---------ISSVYGAYLT---------YYFVIVGIIAVFFHMSHY 193

  Fly  1042 -----VLFVERFIHY--------SFMAE-HTDLRHIMGVGIAITRG--------------SAASL 1078
                 .||..||::|        :|:.: |.:  |...:.:.:..|              :.|::
Yeast   194 NGLNRALFASRFVNYIRGHFVLPTFLVDKHAN--HFKFLNVEVFTGLMPNSLEAWIIFGYTLANI 256

  Fly  1079 SFC--------YSLLL---------LTMSRNLITKLKEFPI-------------QQYIPLDSHIQ 1113
            .|.        |:|:.         |...|:.|....:||:             ...:..:|.|.
Yeast   257 IFLSISYIIDPYNLIFNSHLSQFTRLLADRSGILAFTQFPLIIIFTARNSFLEFLTGVKFNSFIS 321

  Fly  1114 FHK----IAACTALFFSVLHTVGHIVNFYHVSTQSHENLRCLTREVHFASDYKPDITFWLFQTVT 1174
            |||    |....|...|:.:::..|:|  |....|::.|                  :|.|
Yeast   322 FHKWIGRIMVLNATIHSLSYSLFAIIN--HAFKISNKQL------------------YWKF---- 362

  Fly  1175 GTTGVMLFIIMCIIFVFAHPTIRKKAYNFFWNMHTLYIGLYLLS-------------------LI 1220
               |:....::|::.|.:...:||:.|.||...|.:...|:...                   ||
Yeast   363 ---GIASITVLCVLLVLSLGIVRKRHYEFFLYTHIILALLFFYCCWQHVKIFNGWKEWIVVSLLI 424

  Fly  1221 HGLARLTGPPRFWMFFLGPGIVYTLDKIVSLRTKYMALDVIDTDLLPSD----VIKIKFYRPPNL 1281
            .||.:|.   |.|             .|:..|.....|..::|...|.|    ||..|:.|..:.
Yeast   425 WGLEKLF---RIW-------------NILQFRFPKATLINLNTSNNPHDEMFKVIIPKYNRRWHS 473

  Fly  1282 KYLSGQWVRLSCTAFRPH-----EMHSFTLTSAPHENFLSCHIKAQGPWTWKLRNYFDPCNYNPE 1341
            |  .||:    |..:..|     :.|.||:.....:..|.  ||.:...|..:.|:... :.|.:
Yeast   474 K--PGQY----CFIYFLHPLVFWQCHPFTIIDEGEKCVLV--IKPKSGLTRFIYNHILQ-SLNGK 529

  Fly  1342 DQPKIRIEGPFGGGNQDWYKFEVAVMVGGGIGV---TPYASILN---------DLVFGTSTNRYS 1394
            .|.::.||||:|..|....||:..:::.||.|:   ..:|..|:         ||:
Yeast   530 LQLRVAIEGPYGPSNLHLDKFDHLLLLSGGTGLPGPLDHAIKLSRNPDKPKSIDLI--------- 585

  Fly  1395 GVACKKVYFLWICPSHKHFEWFIDVLRDVEKKDVTNVLEIHIFITQFFHKFDLRTTMLYICENHF 1459
             :|.|...||   ..:|.     ::|   |.|:..:.:.:.:::||       :|.:........
Yeast   586 -MAIKNPSFL---NGYKS-----EIL---ELKNSRSHVNVQVYLTQ-------KTAVTKAANARD 631

  Fly  1460 QRLSKTSIFTGLKAVNHFG--RPDMSSFLKFVQKKHSYVSKIGVFSCGPRPLTKSVMSACDEVNK 1522
            |.:....|.|.|.:..|.|  ||:.|:.::...|.......:.|..|||..|.       |:|..
Yeast   632 QLIHFDDIMTELTSFAHIGNARPNFSNVIENAIKSTPPGDSLAVVCCGPPVLV-------DDVRN 689

  Fly  1523 T---RKLPY---FIHHFENF 1536
            |   :.|.|   .|.:||.:
Yeast   690 TVSQKLLGYPERIIEYFEEY 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Duox	NP_001259968.1	An_peroxidase	70..580	CDD:281139
		dual_peroxidase_like	72..625	CDD:188652
		EFh	827..882	CDD:238008
		EFh	860..921	CDD:238008
		EF-hand_7	860..920	CDD:290234
		EFh	895..966	CDD:238008	9/35 (26%)
		EF-hand_7	899..965	CDD:290234	9/34 (26%)
		Ferric_reduct	1084..1217	CDD:280043	31/158 (20%)
		NOX_Duox_like_FAD_NADP	1265..1536	CDD:99783	70/299 (23%)
FRE6	NP_013049.1	Ferric_reduct	290..402	CDD:396386	27/138 (20%)
		FAD_binding_8	438..544	CDD:285293	29/114 (25%)
		NAD_binding_6	565..692	CDD:369657	33/161 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810