DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Duox and FRO3

DIOPT Version :9

Sequence 1:	NP_001259968.1	Gene:	Duox / 33477	FlyBaseID:	FBgn0283531	Length:	1537	Species:	Drosophila melanogaster
Sequence 2:	NP_001185067.1	Gene:	FRO3 / 838910	AraportID:	AT1G23020	Length:	717	Species:	Arabidopsis thaliana

Alignment Length:	673	Identity:	134/673 - (19%)
Similarity:	242/673 - (35%)	Gaps:	190/673 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   972 FVAIGLDCKGAKQNFLDTSTNV----ARMTSFNIEPMQDKPRHWLLAKWDAYITFLEENRQNIFY 1032
            |..|.|...|:....|...|.|    :||....|:......|..|:......:|..|     :.:
plant    91 FPMILLASLGSIYLHLKKQTRVNQFNSRMDRKKIDKFGALKRPMLVKAGLGIVTVTE-----VMF 150

  Fly  1033 LFLFYVVTIVLFVERFIH-------YSFMAEHTDLRHIMGVGIAITRGSAASLSFCYSLLLLTMS 1090
            |.:|..:.:......|.|       .|...:..:|.......||:..|...::  |...|...::
plant   151 LMMFMALLLWSLANYFYHTFVTITPQSLPTDGDNLWQARLDSIAVRLGLTGNI--CLGFLFYPVA 213

  Fly  1091 R--NLITKLKEFPIQQYIPLDSHIQFHKIAACTALFFSVLHTVGHIVNFYHVST-QSHENLRCLT 1152
            |  :|:..:.       :..:|..::|.......:.....|.:.:.:  |.:|| |..:.|.
plant   214 RGSSLLAAVG-------LTSESSTKYHIWLGNLVMTLFTSHGLCYCI--YWISTNQVSQMLE--- 266

  Fly  1153 REVHFASDYKPDITFWLFQTVTGTTGVMLFIIMCIIFVFAHPTIRKKAYNFFWNMHTLYIGLYLL 1217
                           |....::...|.:..:...:::....|.||::.:..|:..|.||:...|.
plant   267 ---------------WDRTGISHLAGEIALVAGLLMWATTFPAIRRRFFEVFFYTHYLYMVFMLF 316

  Fly  1218 SLIH-GLA-RLTGPPRFWMFFLGPGIVYTLDKIVSLRTKYMALDVIDTDLLPSDVIKIKFYRPPN 1280
            .:.| |:: .|...|.|::|.        :|:.:........:.::...:||.:.:::.|.:.|.
plant   317 FVFHVGISYALISFPGFYIFM--------VDRFLRFLQSRNNVKLVSARVLPCETVELNFSKNPM 373

  Fly  1281 LKYLSGQWVRLSCTAFRPHEMHSFTLTSA----PHENFLSCHIKAQGPWTWKLRNYFDPCNYNPE 1341
            |.|.....:.::..:....:.|.||:||:    |.:  ||..||:||.|:.||.:..  .:.|..
plant   374 LMYSPTSILFVNIPSISKLQWHPFTITSSSKLEPKK--LSVMIKSQGKWSSKLHHML--ASSNQI 434

  Fly  1342 DQPKIRIEGPFGGGNQDWYKFEVAVMVGGGIGVTPYASILNDLVFGTSTNRYSGVACKKVYFLWI 1406
            |...:.:|||:|..:.|:.:.:..|||.||.|:||:.||:.||::.:|||.|     |......|
plant   435 DHLAVSVEGPYGPASTDYLRHDSLVMVSGGSGITPFISIIRDLLYVSSTNAY-----KTPKITLI 494

  Fly  1407 C---------------PSHKHFEWFID------VLRD------------------VEKKDVTNVL 1432
            |               |:......|||      |.|:                  |..:.::.:|
plant   495 CAFKNSSDLSMLNLILPNSTEISSFIDIQIKAFVTREKVSTCNMNIIKTLSFKPYVSDQPISPIL 559

  Fly  1433 E-------------------IHIFITQFFHKFDL----------RTTMLY--------------- 1453
            .                   |.|.|...:|.:.:          .|:::|
plant   560 GPNSWLWLATILSSSFMIFIIIIAIISRYHIYPIDQSSKEYTSAYTSLIYLLAISISVVATSTVA 624

  Fly  1454 -ICENHFQRLSKTSIFTGL---------------------KAVN-HFG-RPDMSSFLKFVQKKHS 1494
             :|       :|.|.|.||                     :..| |:| ||:::..|..::.
plant   625 MLC-------NKKSYFKGLYQNVDALSPLMIESSPDQLLPEFTNIHYGERPNLNKLLVGLKG--- 679

  Fly  1495 YVSKIGVFSCGPRPLTKSVMSAC 1517
              |.:||..||||.:.:.|...|
plant   680 --SSVGVLVCGPRKMREEVAKIC 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Duox	NP_001259968.1	An_peroxidase	70..580	CDD:281139
		dual_peroxidase_like	72..625	CDD:188652
		EFh	827..882	CDD:238008
		EFh	860..921	CDD:238008
		EF-hand_7	860..920	CDD:290234
		EFh	895..966	CDD:238008
		EF-hand_7	899..965	CDD:290234
		Ferric_reduct	1084..1217	CDD:280043	20/135 (15%)
		NOX_Duox_like_FAD_NADP	1265..1536	CDD:99783	82/364 (23%)
FRO3	NP_001185067.1	PLN02292	27..717	CDD:215165	134/673 (20%)
		Ferric_reduct	203..317	CDD:280043	22/142 (15%)
		NOX_Duox_like_FAD_NADP	353..536	CDD:99783	53/191 (28%)
		NAD_binding_6	455..700	CDD:285298	53/261 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000155
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810