DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Duox and AT1G19230

DIOPT Version :9

Sequence 1:	NP_001259968.1	Gene:	Duox / 33477	FlyBaseID:	FBgn0283531	Length:	1537	Species:	Drosophila melanogaster
Sequence 2:	NP_001319042.1	Gene:	AT1G19230 / 838506	AraportID:	AT1G19230	Length:	952	Species:	Arabidopsis thaliana

Alignment Length:	860	Identity:	199/860 - (23%)
Similarity:	366/860 - (42%)	Gaps:	155/860 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   793 AETRERRQKRLEYFFREAYALTFGLRPGERRRRSDASSDGEVMTVMRT----------------- 840
            :.|...|.:.||   |:. |:|.|:.....:|:.||.......:..|.
plant   129 SSTAGERDRDLE---RQT-AVTLGILTARDKRKEDAKLQRSTSSAQRALKGLQFINKTTRGNSCV 189

  Fly   841 -------------------SLSK------AEFAAALGMKPNDMFVRKMFNIV---DKDQDGRISF 877
                               ||||      .:|...:||..:..|...:|:.:   .:.:..:|:.
plant   190 CDWDCDCDQMWKKVEKRFESLSKNGLLARDDFGECVGMVDSKDFAVSVFDALARRRRQKLEKITK 254

  Fly   878 QEFLETVVLFSRGKTDDKLRIIFDMCDNDRNGVIDKGELSEMMRSLVEIARTTSLGDDQVTELID 942
            .|..:..:..|....|.:|:|.|||.|::.:|.|.:.|:.|::.......:...| .:|..|...
plant   255 DELHDFWLQISDQSFDARLQIFFDMADSNEDGKITREEIKELLMLSASANKLAKL-KEQAEEYAS 318

  Fly   943 GMFQDVGLEHKNHLTYQDFKLMMKEYKGDFVAIGLDCKGAKQNF---LDTSTNVARMTSFNIEPM 1004
            .:.:::..|:..::.....:.::.:            :.|..|:   |.|::........|:
plant   319 LIMEELDPENFGYIELWQLETLLLQ------------RDAYMNYSRPLSTTSGGVSTPRRNL--- 368

  Fly  1005 QDKPRHWLLAKWDAYITFLEENRQNIFYLFLFYVVTIVLFVERFIHYSFMAEHTDLRHIMGVGIA 1069
             .:|||.:..........:.:|.|..:.|.::.::..:|||.:|:.|...|..    .:||..:.
plant   369 -IRPRHVVQKCRKKLQCLILDNWQRSWVLLVWVMLMAILFVWKFLEYREKAAF----KVMGYCLT 428

  Fly  1070 ITRGSAASLSFCYSLLLLTMSRNLITKLKEFPIQQYIPLDSHIQFHKIAACTALFFSVLHTVGHI 1134
            ..:|:|.:|....:|:||.:.||.:|.|:....:..:|.|.:|.||||.||......::|...|:
plant   429 TAKGAAETLKLNMALVLLPVCRNTLTWLRSTRARACVPFDDNINFHKIIACAIAIGILVHAGTHL 493

  Fly  1135 V-NFYHVSTQSHENLRCLTREVHFASDY---KPDITFW-LFQTVTGTTGVMLFIIMCIIFVFAH- 1193
            . :|..:...|.|..      |..||.:   ||  ||. |.....|.||:.:.|:..|.|..|.
plant   494 ACDFPRIINSSPEQF------VLIASAFNGTKP--TFKDLMTGAEGITGISMVILTTIAFTLAST 550

  Fly  1194 -----------PTIRKKAYNFFWNMHTLYIGLYLLSLIHGLARLTGPPRF----WMFFLGPGIVY 1243
                       |..|...:|.||..|.|.:.:|::.::||.........:    ||:...|.::|
plant   551 HFRRNRVRLPAPLDRLTGFNAFWYTHHLLVVVYIMLIVHGTFLFFADKWYQKTTWMYISVPLVLY 615

  Fly  1244 TLDK-IVSLRTKYMALDVIDTDLLPSDVIKIKFYRPPNLKYLSGQWVRLSCTAFRPHEMHSFTLT 1307
            ..:: :.:.|:|:.::.::...:||.:|:.:...:||..||.|||::.|.|......|.|.|::|
plant   616 VAERSLRACRSKHYSVKILKVSMLPGEVLSLIMSKPPGFKYKSGQYIFLQCPTISRFEWHPFSIT 680

  Fly  1308 SAPHENFLSCHIKAQGPWTWKLR-----------------NYFDPCNYNPEDQPKIRIEGPFGGG 1355
            |||.::.||.||:..|.||.:||                 .:...||.:..::||:.::||:|..
plant   681 SAPGDDQLSVHIRTLGDWTEELRRVLTVGKDLSTCVIGRSKFSAYCNIDMINRPKLLVDGPYGAP 745

  Fly  1356 NQDWYKFEVAVMVGGGIGVTPYASILNDLVFGT---------STNRYSGVACK------------ 1399
            .||:..::|.:::|.|||.||:.|||.||:..:         |.:.:|..:|.
plant   746 AQDYRSYDVLLLIGLGIGATPFISILKDLLNNSRDEQTDNEFSRSDFSWNSCTSSYTTATPTSTH 810

  Fly  1400 -------KVYFLWICPSHKHFEWFIDVLRDVEKKDVTNVLEIHIFITQFFHKFDLRTTMLYICE- 1456
                   |.:|.|:.......|||..|:.::...|....:|:|.::|..:.:.|.|:|::.:.:
plant   811 GGKKKAVKAHFYWVTREPGSVEWFRGVMEEISDMDCRGQIELHNYLTSVYDEGDARSTLIKMVQA 875

  Fly  1457 -NHFQRLSKTSIFTGLKAVNHFGRPDMSSFLKFVQKKHSYVSKIGVFSCGPRPLTKSVMSACDEV 1520
             ||.:.  ...|.:|.:...||.||:.......:.:||.. |.:|||.||.:.:.|.:.....::
plant   876 LNHAKH--GVDILSGTRVRTHFARPNWKEVFSSIARKHPN-STVGVFYCGIQTVAKELKKQAQDM 937

  Fly  1521 NK--TRKLPYFIHHF 1533
            ::  |.:..:...||
plant   938 SQKTTTRFEFHKEHF 952

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Duox	NP_001259968.1	An_peroxidase	70..580	CDD:281139
		dual_peroxidase_like	72..625	CDD:188652
		EFh	827..882	CDD:238008	14/99 (14%)
		EFh	860..921	CDD:238008	15/63 (24%)
		EF-hand_7	860..920	CDD:290234	15/62 (24%)
		EFh	895..966	CDD:238008	14/70 (20%)
		EF-hand_7	899..965	CDD:290234	12/65 (18%)
		Ferric_reduct	1084..1217	CDD:280043	44/149 (30%)
		NOX_Duox_like_FAD_NADP	1265..1536	CDD:99783	86/318 (27%)
AT1G19230	NP_001319042.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	66	1.000	Domainoid score	I3552
eggNOG	1	0.900	-	-		E1_KOG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000155
OrthoInspector	1	1.000	-	-		otm2409
orthoMCL	1	0.900	-	-		OOG6_100242
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X184
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.710