DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Duox and RBOHB

DIOPT Version :9

Sequence 1:	NP_001259968.1	Gene:	Duox / 33477	FlyBaseID:	FBgn0283531	Length:	1537	Species:	Drosophila melanogaster
Sequence 2:	NP_973799.1	Gene:	RBOHB / 837430	AraportID:	AT1G09090	Length:	843	Species:	Arabidopsis thaliana

Alignment Length:	898	Identity:	215/898 - (23%)
Similarity:	397/898 - (44%)	Gaps:	135/898 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   719 LKHIDVVSVEESATNHIKK----------KPYILLRVPSDHDLVLELESYGARRKFVKKLEDFLL 773
            ::..::.|..|..||.|.:          :.|:        ::.||:.            ::.:.
plant     1 MREEEMESSSEGETNKISRCKATGSDNPDEDYV--------EITLEVR------------DETIN 45

  Fly   774 LHKKEMTLMEVNRDIMLARAETRER----RQKRLEYFFREAYALTFGLRPGERRRRSDASSDGEV 834
            ..|.:.||    |.::..|.:|..:    ..:||:.  .:::...|.||......::||...|..
plant    46 TMKAKATL----RSVLSGRLKTMVKSLSFASRRLDR--SKSFGAMFALRGLRFIAKNDAVGRGWD 104

  Fly   835 MTVMR-------TSLSKAEFAAALGMKPNDMFVRKMFNIVDKDQ---DGRISFQEFLETVVLFSR 889
            ...||       ..|.|::|...:||..:..||.::|..:.:.:   ...|:..|..|.....:.
plant   105 EVAMRFDKLAVEGKLPKSKFGHCIGMVESSEFVNELFEALVRRRGTTSSSITKTELFEFWEQITG 169

  Fly   890 GKTDDKLRIIFDMCDNDRNGVIDKGELSEMMRSLVEIARTTSLGDDQVTELIDGMFQDVGLEHKN 954
            ...||:|:|.|||.|.:.:|.|...|:.|:: :|...|...|...:.|.|....:.:::..::..
plant   170 NSFDDRLQIFFDMVDKNLDGRITGDEVKEII-ALSASANKLSKIKENVDEYAALIMEELDRDNLG 233

  Fly   955 HLTYQDFKLMMKEYKGDFVAIGLDCKGAKQNFLDTSTN---VARMTSFNIEPMQDKPRHWLLAKW 1016
            ::...:.:.::.:..            ::.|...:|.|   :.:|.|..:.|.:|:......|..
plant   234 YIELHNLETLLLQVP------------SQSNNSPSSANKRALNKMLSQKLIPTKDRNPVKRFAMN 286

  Fly  1017 DAYITFLEENRQNIFYLFLFYVVTIVLFVERFIHYSFMAEHTDLRHIMGVGIAITRGSAASLSFC 1081
            .:|  |..||.:.|:.|.|:..:.|.||..:|:.|    :...:..:||..:.:.:|||.:|.|.
plant   287 ISY--FFLENWKRIWVLTLWISICITLFTWKFLQY----KRKTVFEVMGYCVTVAKGSAETLKFN 345

  Fly  1082 YSLLLLTMSRNLIT--KLKEFPIQQYIPLDSHIQFHKIAACTALFFSVLHTVGHIV----NFYHV 1140
            .:|:||.:.||.||  :.|...|...:|.|.:|.|||:.|........||.:.|:.    ...|.
plant   346 MALILLPVCRNTITWLRTKSKLIGSVVPFDDNINFHKVVAFGIAVGIGLHAISHLACDFPRLLHA 410

  Fly  1141 STQSHENLRCLTREVHFASDYKPDITFWLFQTVTGTTGVMLFIIMCIIFVFAHPTIRKK------ 1199
            .....|.::      .|..|.:|:...|..:...|.|||.:.::|.:.:|.|....|:.
plant   411 KNVEFEPMK------KFFGDERPENYGWFMKGTDGWTGVTMVVLMLVAYVLAQSWFRRNRANLPK 469

  Fly  1200 ------AYNFFWNMHTLYIGLYLLSLIHG----LARLTGPPRFWMFFLGPGIVYTLDKIV-SLRT 1253
                  .:|.||..|.|::.:|:|.::||    |::.......||:...|.::|..:::: :.|.
plant   470 SLKRLTGFNAFWYSHHLFVIVYVLLIVHGYFVYLSKEWYHKTTWMYLAVPVLLYAFERLIRAFRP 534

  Fly  1254 KYMALDVIDTDLLPSDVIKIKFYRPPNLKYLSGQWVRLSCTAFRPHEMHSFTLTSAPHENFLSCH 1318
            ...|:.|:...:.|.:|:.:...:|...||.|||::.::|:...|.:.|.|::|||..:::||.|
plant   535 GAKAVKVLKVAVYPGNVLSLYMSKPKGFKYTSGQYIYINCSDVSPLQWHPFSITSASGDDYLSVH 599

  Fly  1319 IKAQGPWTWKLRN-YFDPCNYNPEDQ-----------------PKIRIEGPFGGGNQDWYKFEVA 1365
            |:..|.||.:|:: |...|......|                 |::.|:||:|...||:..::|.
plant   600 IRTLGDWTSQLKSLYSKVCQLPSTSQSGLFIADIGQANNITRFPRLLIDGPYGAPAQDYRNYDVL 664

  Fly  1366 VMVGGGIGVTPYASILNDLV----------FGTSTNRYSGVACKKVYFLWICPSHKHFEWFIDVL 1420
            ::||.|||.||..||:.|::          .||:.:..:.||.|:.||.|:.......|||.:|:
plant   665 LLVGLGIGATPLISIIRDVLNNIKNQNSIERGTNQHIKNYVATKRAYFYWVTREQGSLEWFSEVM 729

  Fly  1421 RDVEKKDVTNVLEIHIFITQFFHKFDLRTTMLYICENHFQRLSKTSIFTGLKAVNHFGRPDMSSF 1485
            .:|.:.|...::|:|.:.|..:.:.|.|:.::.:.::.....|...|.:|.:...||.||:..|.
plant   730 NEVAEYDSEGMIELHNYCTSVYEEGDARSALITMLQSLHHAKSGIDIVSGTRVRTHFARPNWRSV 794

  Fly  1486 LKFVQKKHSYVSKIGVFSCGPRPLTKSVMSACDEVNK--TRKLPYFIHHFENF 1536
            .|.|...| ...::|||.||...:...:.....:.::  |.|   |..|.|||
plant   795 FKHVAVNH-VNQRVGVFYCGNTCIIGELKRLAQDFSRKTTTK---FEFHKENF 843

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Duox	NP_001259968.1	An_peroxidase	70..580	CDD:281139
		dual_peroxidase_like	72..625	CDD:188652
		EFh	827..882	CDD:238008	15/64 (23%)
		EFh	860..921	CDD:238008	17/63 (27%)
		EF-hand_7	860..920	CDD:290234	17/62 (27%)
		EFh	895..966	CDD:238008	15/70 (21%)
		EF-hand_7	899..965	CDD:290234	13/65 (20%)
		Ferric_reduct	1084..1217	CDD:280043	39/150 (26%)
		NOX_Duox_like_FAD_NADP	1265..1536	CDD:99783	84/300 (28%)
RBOHB	NP_973799.1	NADPH_Ox	78..173	CDD:285598	19/94 (20%)
		EF-hand_7	180..237	CDD:290234	13/57 (23%)
		EFh	180..237	CDD:298682	13/57 (23%)
		Ferric_reduct	345..494	CDD:280043	39/154 (25%)
		FAD_binding_8	537..655	CDD:285293	33/117 (28%)
		NAD_binding_6	661..825	CDD:285298	46/164 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	78	1.000	Domainoid score	I3057
eggNOG	1	0.900	-	-		E1_KOG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H9689
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000155
OrthoInspector	1	1.000	-	-		otm2409
orthoMCL	1	0.900	-	-		OOG6_100242
Panther	1	1.100	-	-	O	PTHR11972
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X184
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.810