DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Duox and FRO1

DIOPT Version :9

Sequence 1:	NP_001259968.1	Gene:	Duox / 33477	FlyBaseID:	FBgn0283531	Length:	1537	Species:	Drosophila melanogaster
Sequence 2:	NP_171665.1	Gene:	FRO1 / 837194	AraportID:	AT1G01590	Length:	704	Species:	Arabidopsis thaliana

Alignment Length:	696	Identity:	136/696 - (19%)
Similarity:	227/696 - (32%)	Gaps:	265/696 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   989 TSTNVARMTSFNIEPMQDKPRHWLLAKWDAYITFLEENRQ------------------------- 1028
            |.|.|..:|.|....:      |.||.: .|.||:....:
plant   120 TVTEVMFLTMFMALLL------WSLANY-MYRTFVNVTSESAATDGNNLWQARLDLIAVRIGIVG 177

  Fly  1029 NIFYLFLFYVV--------TIVLFVERFIHYSFMAEHTDLRHIMGVGIAITRGSAASLSFCYSLL 1085
            ||...||||.|        .:.|..|..|.|     |..|.|:  |.|..|     |...||  .
plant   178 NICLAFLFYPVARGSSLLAAVGLTSESSIKY-----HIWLGHL--VMIIFT-----SHGLCY--F 228

  Fly  1086 LLTMSRN-LITKLKEFPIQQYIPLDSHIQFHKIAACTALFFSVLHTVGHIVNFYHVSTQSHENLR 1149
            :..:|:| |::|:.|
plant   229 IYWISKNQLVSKMLE-------------------------------------------------- 243

  Fly  1150 CLTREVHFASDYKPDITFWLFQTVTGTTGVMLFIIMCIIFVFAHPTIRKKAYNFFWNMHTLYIGL 1214
                              |....|:...|.:..:...:::|..:|.||::.:..|:..|.|||..
plant   244 ------------------WDRTAVSNLAGEIALVAGLMMWVTTYPKIRRRLFEVFFYSHYLYIVF 290

  Fly  1215 YLLSLIH-GLARLTGP-PRFWMFFLGPGIVYTLDKIVSLRTKYMALDVIDTDLLPSDVIKIKFYR 1277
            .|..:.| |::....| |.|::|.        :|:.:........:.::...:||.|.:::.|.:
plant   291 MLFFVFHVGISHALIPLPGFYIFL--------VDRFLRFLQSRNNVKLVSARVLPCDTVELNFSK 347

  Fly  1278 PPNLKYLSGQWVRLSCTAFRPHEMHSFTLTSAP--HENFLSCHIKAQGPWTWKLRNYFDPCNYNP 1340
            .|.|.|.....:.::..:....:.|.||:.|:.  ....||..||:||.|:.||   :|..:.:.
plant   348 NPMLMYSPTSTMFVNIPSISKLQWHPFTIISSSKLEPETLSVMIKSQGKWSTKL---YDMLSSSS 409

  Fly  1341 EDQPK---IRIEGPFGGGNQDWYKFEVAVMVGGGIGVTPYASILNDLVFGTSTNRYSGVACKKVY 1402
            .||..   :.:|||:|..:.|:.:.|..|||.||.|:||:.||:.||.:.:||::     ||...
plant   410 SDQINRLAVSVEGPYGPSSTDFLRHESLVMVSGGSGITPFISIVRDLFYMSSTHK-----CKIPK 469

  Fly  1403 FLWICPSHKHFEW------------------FID--VLRDVEKKDVTNVLE-------------- 1433
            ...||......:.                  |:|  :...|.:::.|:|.|
plant   470 MTLICAFKNSSDLSMLDLILPTSGLTTDMASFVDIQIKAFVTREEKTSVKESTHNRNIIKTRHFK 534

  Fly  1434 ---------------------------------IHIFITQF-FHKFDLRT---TMLYICENHFQR 1461
                                             |...||:: .|..|..:   |..|....:...
plant   535 PNVSDQPISPILGPNSWLCLAAILSSSFMIFIVIIAIITRYHIHPIDQNSEKYTWAYKSLIYLVS 599

  Fly  1462 LSKTSIFTGLKAV------------------------------------NHFG-RPDMSSFLKFV 1489
            :|.|.:.|...|:                                    .|:| ||:::..|..:
plant   600 ISITVVTTSTAAMLWNKKKYYAKNDQYVDNLSPVIIESSPQQLISQSTDIHYGERPNLNKLLVGL 664

  Fly  1490 QKKHSYVSKIGVFSCGPRPLTKSVMSACDEVNKTRKLPYFIHHFEN 1535
            :.     |.:|:..|||:.:.:.|...| .......|     |||:
plant   665 KG-----SSVGILVCGPKKMRQKVAKIC-SFGSAENL-----HFES 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Duox	NP_001259968.1	An_peroxidase	70..580	CDD:281139
		dual_peroxidase_like	72..625	CDD:188652
		EFh	827..882	CDD:238008
		EFh	860..921	CDD:238008
		EF-hand_7	860..920	CDD:290234
		EFh	895..966	CDD:238008
		EF-hand_7	899..965	CDD:290234
		Ferric_reduct	1084..1217	CDD:280043	17/133 (13%)
		NOX_Duox_like_FAD_NADP	1265..1536	CDD:99783	80/384 (21%)
FRO1	NP_171665.1	PLN02292	1..704	CDD:215165	136/696 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000155
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810