DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Duox and FRO8

DIOPT Version :9

Sequence 1:	NP_001259968.1	Gene:	Duox / 33477	FlyBaseID:	FBgn0283531	Length:	1537	Species:	Drosophila melanogaster
Sequence 2:	NP_199827.2	Gene:	FRO8 / 835081	AraportID:	AT5G50160	Length:	728	Species:	Arabidopsis thaliana

Alignment Length:	668	Identity:	131/668 - (19%)
Similarity:	239/668 - (35%)	Gaps:	218/668 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1036 FYVVTIVLFVERFIHYSFMAE-HTDLRHIMGV-------------GIAITRGSAASLSFCYSLLL 1086
            |.::.::||: .|:.::|.|. ..|.:.:|.|             .:|...|..|..  |.||||
plant   110 FEILALLLFL-LFLAWNFYARVSNDFKKLMPVKTMNLNLWQLKYYRVATRFGLLAEA--CLSLLL 171

  Fly  1087 LTMSRNLITKLKEFPIQQYIPLDSHIQFHKIAACTALFFSVLH--------TVGHIVNFYHVSTQ 1143
            ..:.|.    |..|.:.. |...:.:::|.......:|||::|        |:.|     |:..:
plant   172 FPVLRG----LSMFRLLN-IEFAASVKYHVWFGTGLIFFSLVHGGSTLFIWTITH-----HIEEE 226

  Fly  1144 SHENLRCLTREVHFASDYKPDITFWLFQTVTG---TTGVMLFIIMCIIFVFAHPTIRKKAYNFFW 1205
                                   .|.:|. ||   ..|::..:...::::.:.|.||:|.:..|:
plant   227 -----------------------IWKWQR-TGRVYVAGLISLVTGLLMWITSLPQIRRKNFEVFY 267

  Fly  1206 NMHTLYIGLYLLSLIHGLARLTGPPRF-WMFFLGPGI-VYTLDKIVSLRTKYMALDVIDTDLLPS 1268
            ..|.|||...:..|.|     .|...| |:.   ||: ::.||||:.:........::..:|...
plant   268 YTHHLYIVFLVAFLFH-----AGDRHFYWVL---PGMFLFGLDKILRIVQSRSESCILSANLFSC 324

  Fly  1269 DVIKIKFYRPPNLKYLSGQWVRLSCTAFRPHEMHSFTL--TSAPHENFLSCHIKAQGPWTWKLRN 1331
            ..|::...:.|.|.|....::.|:.......:.|.|::  :|:..::.||..:|.:|.||..:.|
plant   325 KAIELVLPKDPMLNYAPSSFIFLNIPLVSRFQWHPFSIISSSSVDKHSLSIMMKCEGDWTNSVYN 389

  Fly  1332 YFDP---CNYNPEDQPKIRIEGPFGGGNQDWYKFEVAVMVGGGIGVTPYASILNDLVFGTSTNRY 1393
            ..:.   |. |..:...:|:|||:|..:.|:.:::...:|.||||:||:.|||.:|   .|.||.
plant   390 KIEEAANCE-NKINNIIVRVEGPYGPASVDFLRYDNLFLVAGGIGITPFLSILKEL---ASKNRL 450

  Fly  1394 SGVACKKVYFLWICPSHKHFEWFIDVLRDV-----------------EKKD------------VT 1429
            .  :.|:|..::...:.:.....:.:...:                 |||.            .:
plant   451 K--SPKRVQLVFAVRTFQDLNMLLPIASIIFNPIYNLNLKLKVFVTQEKKPSNGTTTLQEFLAQS 513

  Fly  1430 NVLEIHIFITQFFHKFDLR--------TTMLYIC--------------------ENH-------- 1458
            .|..||:...:.:.:|.:|        .|::.|.                    :||
plant   514 QVQSIHLGTDEDYSRFPIRGPESFRWLATLVLITVLTFLGFLIGLSHFFIPSEHKNHSGVMKLAA 578

  Fly  1459 ----------------------------------------------FQRLSKTSI-------FTG 1470
                                                          ..|:||..:       ||.
plant   579 SGAMKTAKEKVPSWVPDLIIIVSYVIAISVGGFAATILQRRRKHKEAPRMSKEVVIKPEERNFTE 643

  Fly  1471 LKAVN-------HFG-RPDMSSFLKFVQKKHSYVSKIGVFSCGPRPLTKSVMSAC---------D 1518
            ||.:.       |.| ||.:...:...:|.....|.:||..|||..:.::|.|.|         :
plant   644 LKPIPITEEHEIHIGERPKLEEIMSEFEKNLRGWSSVGVLVCGPESVKEAVASMCRQWPQCFGVE 708

  Fly  1519 EVNKTRKLPYFIHHFENF 1536
            ::.::|.......|..||
plant   709 DLRRSRMKMNLNFHSLNF 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Duox	NP_001259968.1	An_peroxidase	70..580	CDD:281139
		dual_peroxidase_like	72..625	CDD:188652
		EFh	827..882	CDD:238008
		EFh	860..921	CDD:238008
		EF-hand_7	860..920	CDD:290234
		EFh	895..966	CDD:238008
		EF-hand_7	899..965	CDD:290234
		Ferric_reduct	1084..1217	CDD:280043	29/143 (20%)
		NOX_Duox_like_FAD_NADP	1265..1536	CDD:99783	75/410 (18%)
FRO8	NP_199827.2	PLN02844	1..728	CDD:215453	131/668 (20%)
		Ferric_reduct	162..280	CDD:280043	32/153 (21%)
		NOX_Duox_like_FAD_NADP	321..495	CDD:99783	40/179 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000155
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810