DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Duox and FRO7

DIOPT Version :9

Sequence 1:	NP_001259968.1	Gene:	Duox / 33477	FlyBaseID:	FBgn0283531	Length:	1537	Species:	Drosophila melanogaster
Sequence 2:	NP_199785.2	Gene:	FRO7 / 835037	AraportID:	AT5G49740	Length:	747	Species:	Arabidopsis thaliana

Alignment Length:	455	Identity:	112/455 - (24%)
Similarity:	196/455 - (43%)	Gaps:	108/455 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  1029 NIFYLFLFYVVTI-VLFVERFIHY------SFMAEHTDLRHIMGVGIAITRGSAASLSFCYSLLL 1086
            ::|:|:..|..|: .|.|..:.|.      .|:.|.|.||..| :|:           .|...|.
plant   147 SVFFLWAIYAYTLRNLNVLDYFHVLPNNRSIFLLELTGLRFGM-IGL-----------LCMVFLF 199

  Fly  1087 LTMSR-NLITKLKEFPIQQYIPLDSHIQFHK-IAACTALFFSVLHTVGHIVNFYHVSTQSHENLR 1149
            |.:|| :::.:|.:      ||.:...::|. :...|..||| ||.:.::|.:    |...:.|.
plant   200 LPISRGSILLRLID------IPFEHATRYHVWLGHITMTFFS-LHGLCYVVGW----TIQGQLLE 253

  Fly  1150 CLTREVHFASDYKPDITFWLFQTVTGTTGVMLFIIMCIIFVFAHPTIRKKAYNFFWNMHTLYI-- 1212
            .|..              |....:....||:..:...:::|.:..|:||..:..|:..|.|||
plant   254 LLFE--------------WKATGIAVLPGVISLVAGLLMWVTSLHTVRKNYFELFFYTHQLYIVF 304

  Fly  1213 --------GLYLLSLIHGLARLTGPPRFWMFFLGPGI-VYTLDKIVSLRTKYMALDVIDTDLLPS 1268
                    |.||.|::.|                 || ::.||:.:........:|||....||.
plant   305 VVFLALHVGDYLFSIVAG-----------------GIFLFILDRFLRFYQSRRTVDVISAKSLPC 352

  Fly  1269 DVIKIKFYRPPNLKYLSGQWVRLSCTAFRPHEMHSFTLTSAPHE--NFLSCHIKAQGPWTWKLRN 1331
            ..:::...:|||::|.:..::.|........:.|.|:::|:|.:  :.::..||..|.||.|||:
plant   353 GTLELVLSKPPNMRYNALSFIFLQVKELSWLQWHPFSVSSSPLDGNHHVAVLIKVLGGWTAKLRD 417

  Fly  1332 ----YFDPCN----YNPEDQPKIR--IEGPFGGGNQDWYKFEVAVMVGGGIGVTPYASILNDLVF 1386
                .::..|    .:||..|||.  :|||:|..:.....:|..|:|.||||:||:.:||:|::.
plant   418 QLSTLYEAENQDQLISPESYPKITTCVEGPYGHESPYHLAYENLVLVAGGIGITPFFAILSDILH 482

  Fly  1387 GTSTNRYSGVAC--KKVYFLWICPSHKHFEWFIDVLRDVEKKDVTNV---------LEIHIFITQ 1440
                .:..|..|  .||..:|...:.       |.|..:...|:.::         |||||::|:
plant   483 ----RKRDGKDCLPGKVLVVWAIKNS-------DELSLLSAIDIPSICHFFSKKLNLEIHIYVTR 536

Fly 1441 1440
plant 537 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Duox	NP_001259968.1	An_peroxidase	70..580	CDD:281139
		dual_peroxidase_like	72..625	CDD:188652
		EFh	827..882	CDD:238008
		EFh	860..921	CDD:238008
		EF-hand_7	860..920	CDD:290234
		EFh	895..966	CDD:238008
		EF-hand_7	899..965	CDD:290234
		Ferric_reduct	1084..1217	CDD:280043	32/144 (22%)
		NOX_Duox_like_FAD_NADP	1265..1536	CDD:99783	55/199 (28%)
FRO7	NP_199785.2	PLN02292	31..745	CDD:215165	112/455 (25%)
		Ferric_reduct	190..308	CDD:280043	32/153 (21%)
		NOX_Duox_like_FAD_NADP	344..536	CDD:99783	56/202 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000155
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810