DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Duox and FRO6

DIOPT Version :9

Sequence 1:	NP_001259968.1	Gene:	Duox / 33477	FlyBaseID:	FBgn0283531	Length:	1537	Species:	Drosophila melanogaster
Sequence 2:	NP_199784.2	Gene:	FRO6 / 835036	AraportID:	AT5G49730	Length:	738	Species:	Arabidopsis thaliana

Alignment Length:	456	Identity:	112/456 - (24%)
Similarity:	200/456 - (43%)	Gaps:	110/456 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  1029 NIFYLFLFYVVTI--VLFVERFIHY------SFMAEHTDLRHIMGVGIAITRGSAASLSFCYSLL 1085
            ::|:|:..|..|:  :..:||| |.      ..:.|.|.||..| :|:           .|...|
plant   138 SVFFLWSIYAYTLRNLDLLERF-HVLPKNRSILLLEVTGLRLGM-IGL-----------LCMVFL 189

  Fly  1086 LLTMSR-NLITKLKEFPIQQYIPLDSHIQFHK-IAACTALFFSVLHTVGHIVNFYHVSTQSHENL 1148
            .|.:|| :::.:|.:      ||.:...::|. :...|..||| ||.:.::|.:.         :
plant   190 FLPISRGSILLRLID------IPFEHATRYHVWLGHITMAFFS-LHGLCYVVGWI---------I 238

  Fly  1149 RCLTREVHFASDYKPDITFWLFQTVTGTTGVMLFIIMCIIFVFAHPTIRKKAYNFFWNMHTLYI- 1212
            :....|:.|:         |....:....||:..:...:::|.:..|:||..:..|:..|.|||
plant   239 QGQLLELIFS---------WNAIGIAILPGVISLVAGLLMWVTSLHTVRKNYFELFFYTHQLYIV 294

  Fly  1213 ---------GLYLLSLIHGLARLTGPPRFWMFFLGPGI-VYTLDKIVSLRTKYMALDVIDTDLLP 1267
                     |.|:.|::.|                 || ::.||:.:........:|||....||
plant   295 FIVFLALHVGDYMFSIVAG-----------------GIFLFILDRFLRFCQSRRTVDVISAKSLP 342

  Fly  1268 SDVIKIKFYRPPNLKYLSGQWVRLSCTAFRPHEMHSFTLTSAPHE--NFLSCHIKAQGPWTWKLR 1330
            ...:::...:|||::|.:..::.|........:.|.|:::|:|.:  :.::..||..|.||.|||
plant   343 CGTLELVLSKPPNMRYNALSFIFLQVRELSWLQWHPFSVSSSPLDGNHHVAVLIKVLGGWTAKLR 407

  Fly  1331 ----NYFDPCN----YNPEDQPKIR--IEGPFGGGNQDWYKFEVAVMVGGGIGVTPYASILNDLV 1385
                |.::..|    .:|:..|||.  :|||:|..:.....:|..|:|.||||:||:.:||:|::
plant   408 DQLSNLYEAENQDQLISPQSYPKITTCVEGPYGHESPYHLAYENLVLVAGGIGITPFFAILSDIL 472

  Fly  1386 FGTSTNRYSGVAC--KKVYFLWICPSHKHFEWFIDVLRDVEKKDVTNV---------LEIHIFIT 1439
            .    .:..|.||  .||..:|...:.       |.|..:...|:.::         |||||:||
plant   473 H----RKRDGKACLPSKVLVVWAIKNS-------DELSLLSAIDIPSICPFFSKKLNLEIHIYIT 526

  Fly  1440 Q 1440
            :
plant   527 R 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Duox	NP_001259968.1	An_peroxidase	70..580	CDD:281139
		dual_peroxidase_like	72..625	CDD:188652
		EFh	827..882	CDD:238008
		EFh	860..921	CDD:238008
		EF-hand_7	860..920	CDD:290234
		EFh	895..966	CDD:238008
		EF-hand_7	899..965	CDD:290234
		Ferric_reduct	1084..1217	CDD:280043	31/144 (22%)
		NOX_Duox_like_FAD_NADP	1265..1536	CDD:99783	57/199 (29%)
FRO6	NP_199784.2	PLN02292	24..736	CDD:215165	112/456 (25%)
		Ferric_reduct	181..299	CDD:280043	31/153 (20%)
		NOX_Duox_like_FAD_NADP	335..527	CDD:99783	58/202 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000155
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810